Herediter ve Ailesel Meme Kanserlerinin Aile Öyküsü ile Klinikopatolojik Özelliklerinin Karşılaştırılması; Tek Merkez Deneyimi

Yıl 2021, , 647 - 653, 22.09.2021

Kayhan Özdemir , Merve Yiğit , Yasemin Eyüboğlu Mine Urfalı Havva Belma Koçer

https://doi.org/10.31832/smj.934186

Öz

Amaç: Meme kanseri kadınlarda en sık teşhis edilen kanserdir. Sporadik meme kanserlerinden sonra en sık ailesel ardından herediter meme kanserleri gelir. Çalışmamızda herediter ve ailesel meme kanserlerinin klinikopatolojik özelliklerini kıyaslamayı amaçladık.
Gereç ve Yöntemler: Sakarya Üniversitesi Eğitim ve Araştırma Hastanesinde 2019-2020 yılları arasında tanı konulan meme kanseri olgularında aile hikayesi ve patolojik özellikler göz önünde bulundurularak genetik test yapılan hastaların verileri retrospektif tarandı.
Bulgular: Herediter ve ailesel meme kanserli olgular karşılaştırıldığında herediter meme kanserli hastaların tanıda daha ileri evre oldukları, yüksek Ki-67 indeksine sahip oldukları ve reseptör negatif oldukları saptandı.BRCA1 mutasyonlu olgularda ise BRCA2’ye göre tanıda yüksek histolojik evre, artmış metastatik lenf nodu ve reseptör negatifliği görüldü.
Sonuç: BRCA (Breast Cancer Gene) mutasyonu olan tümörlerin ailesel geçişli meme kanserli hastalara göre daha agresif, BRCA1 mutasyonu olan tümörler ise BRCA2 mutasyonu olan tümörlere göre daha agresif tümörler olduğunu saptadık. Kuvvetli aile öyküsü olan veya herediter meme kanseri şüpheli olgularda erken dönemde genetik danışmanlık desteği alınmalıdır. Bu mutasyonların saptanması hastaların cerrahi ve medikal tedavisinde farklılıklar sebep olacaktır.

Anahtar Kelimeler

Meme kanseri, Herediter, Ailesel

Proje Numarası

E-71522473-050.01.04-605836

Kaynakça

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