BibTex RIS Kaynak Göster

Emergency Management of Posterior Leukoencephalopathy Syndrome

Yıl 2014, Cilt: 4 Sayı: 1, 35 - 38, 01.03.2014
https://doi.org/10.5505/sakaryamj.2014.50480

Öz

Posterior Leukoencephalopathy Syndrome (PLS) is an acute neurologic emergency which is characterized by altered mental functions, headaches, epileptic seizures, visual impairment and often associated with high blood pressure. Exact pathophysiological mechanism is unknown but it is proposed that hypertension originated vasospasm affects the blood brain barrier and consequently leads to cerebral edema. PLS can be diagnosed by clinical and neuroradiological imaging methods. However, inaccurate or delayed diagnosis causes inadequate medical treatment and may result in cerebral hemorrhage, coma and death. This case study is aimed to draw attention to the subject by presenting a patient who has PLS.

Kaynakça

  • Hinchey J, Chaves C, Appignani B, et al. A reversible posterior leukoencephalopathy syndrome. N Engl J Med 1996;8:494–500.
  • Yasuda Y, Akiguchi I, Imai T, Sonobe M, Kage M. Hypertensive brainstem encephalopathy. Intern Med. 2003;42(11):1131-4.
  • Henderson RD, Rajah T, Nicol AJ, Read SJ. Posterior leukoencephalopathy following intrathecal chemotherapy with MRA-documented vasospasm. Neurology. 2003;60(2):326-328.
  • Pizon AF, Wolfson AB. Postpartum focal neurologic deficits: posterior leukoencephalopathy syndrome. J Emerg Med. 2005;29(2):163-6.
  • Ringelstein EB, Knecht S. Cerebral Small Vessel Diseases: Manifestations In Young Women. Current Oppinion in Neurology 2006;19:55-62.
  • Yano Y, Kario K, Fukunaga T, et al. A Case Reversibl Posterior Leukoensephalopathy Syndrome Caused by Ttansient Hypercoagulable State Induced By Infection. Hypertens Res 2005;28:619-623.
  • Ergün T, Lakadamyali H, Yilmaz A. Recurrent posterior reversible encephalopathy syndrome in a hypertensive patient with end-stage renal disease Diagn Interv Radiol. 2008 Dec;14(4):182-5.
  • Weidauer S, Gaa J, Sitzer M, Hefner R, Lanfermann H, Zanella FE. Posterior encephalopathy with vasospasm: MRI and angiography. Neuroradiology. 2003 Dec;45(12):869-76.
  • Casey SO, Sampaio RC, Michel E, Truwit CL. Posterior reversible leukoencephalopathy syndrome: utility of fluidattenuated inversion recovery MR imaging in the detection of cortical and subcortical lesions. Am J Neuroradiol 2000; 21:1199-1206.
  • Sundgren PC, Edvardsson B, Holtas S. Serial investigation of perfusion disturbances and vasogenic oedema in hypertensive encephalopathy by diffusion and perfusion weighted imaging. Neuroradiology. 2002;44(4):299-304.
  • Ay H, Buonanno FS, Schaefer PW, et al. Posterior leukoencephalopathy without severe hypertension: utility of diffusion-weighted MRI. Neurology 1998; 51: 1369-1376.
  • Mukherjee P, Mckinstry RC. Reversible posterior leukoencephalopathy syndrome: evaluation with diffusiontensor imaging. Radiology 2001; 219: 756-765.

Posteriyor Lökolensefalopati Sendromunda Acil Yaklaşım

Yıl 2014, Cilt: 4 Sayı: 1, 35 - 38, 01.03.2014
https://doi.org/10.5505/sakaryamj.2014.50480

Öz

Posteriyor Lökoensefalopati Sendromu (PLES) mental bozukluk, baş ağrısı, epileptik nöbet ve görme bozukluğu ile karakterize, sıklıkla artmış kan basıncı ile birliktelik gösteren akut nörolojik bir acildir. Fizyopatolojik mekanizması kesin olarak bilinmemekte, ancak hipertansiyona yanıt olarak ortaya çıkan vazospazma bağlı olarak kan beyin bariyerinin etkilendiği ve sonuçta serebral ödemin oluştuğu ileri sürülmektedir. Tanı klinik ve nöroradyolojik görüntüleme yöntemleri ile sıklıkla konulabilmektedir. Ancak yanlış tanı veya tanıdaki gecikme nedeni ile tedavinin yapılamadığı durumlarda sendrom serebral hemoraji, koma ve ölümle sonuçlanabilmektedir. Bu yazıda PLES'li bir olgu sunularak konuya dikkat çekilmek istenmiştir.

Kaynakça

  • Hinchey J, Chaves C, Appignani B, et al. A reversible posterior leukoencephalopathy syndrome. N Engl J Med 1996;8:494–500.
  • Yasuda Y, Akiguchi I, Imai T, Sonobe M, Kage M. Hypertensive brainstem encephalopathy. Intern Med. 2003;42(11):1131-4.
  • Henderson RD, Rajah T, Nicol AJ, Read SJ. Posterior leukoencephalopathy following intrathecal chemotherapy with MRA-documented vasospasm. Neurology. 2003;60(2):326-328.
  • Pizon AF, Wolfson AB. Postpartum focal neurologic deficits: posterior leukoencephalopathy syndrome. J Emerg Med. 2005;29(2):163-6.
  • Ringelstein EB, Knecht S. Cerebral Small Vessel Diseases: Manifestations In Young Women. Current Oppinion in Neurology 2006;19:55-62.
  • Yano Y, Kario K, Fukunaga T, et al. A Case Reversibl Posterior Leukoensephalopathy Syndrome Caused by Ttansient Hypercoagulable State Induced By Infection. Hypertens Res 2005;28:619-623.
  • Ergün T, Lakadamyali H, Yilmaz A. Recurrent posterior reversible encephalopathy syndrome in a hypertensive patient with end-stage renal disease Diagn Interv Radiol. 2008 Dec;14(4):182-5.
  • Weidauer S, Gaa J, Sitzer M, Hefner R, Lanfermann H, Zanella FE. Posterior encephalopathy with vasospasm: MRI and angiography. Neuroradiology. 2003 Dec;45(12):869-76.
  • Casey SO, Sampaio RC, Michel E, Truwit CL. Posterior reversible leukoencephalopathy syndrome: utility of fluidattenuated inversion recovery MR imaging in the detection of cortical and subcortical lesions. Am J Neuroradiol 2000; 21:1199-1206.
  • Sundgren PC, Edvardsson B, Holtas S. Serial investigation of perfusion disturbances and vasogenic oedema in hypertensive encephalopathy by diffusion and perfusion weighted imaging. Neuroradiology. 2002;44(4):299-304.
  • Ay H, Buonanno FS, Schaefer PW, et al. Posterior leukoencephalopathy without severe hypertension: utility of diffusion-weighted MRI. Neurology 1998; 51: 1369-1376.
  • Mukherjee P, Mckinstry RC. Reversible posterior leukoencephalopathy syndrome: evaluation with diffusiontensor imaging. Radiology 2001; 219: 756-765.
Toplam 12 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Bölüm Makaleler
Yazarlar

Yücel Yavuz Bu kişi benim

Serdar Oruç Bu kişi benim

Yusuf Yürümez Bu kişi benim

Gülşen Çığşar Bu kişi benim

Fatma Fidan Bu kişi benim

Kamil Tünay Bu kişi benim

Oya Akpınar Oruç Bu kişi benim

Yayımlanma Tarihi 1 Mart 2014
Gönderilme Tarihi 7 Eylül 2015
Yayımlandığı Sayı Yıl 2014 Cilt: 4 Sayı: 1

Kaynak Göster

AMA Yavuz Y, Oruç S, Yürümez Y, Çığşar G, Fidan F, Tünay K, Oruç OA. Posteriyor Lökolensefalopati Sendromunda Acil Yaklaşım. Sakarya Tıp Dergisi. Mart 2014;4(1):35-38. doi:10.5505/sakaryamj.2014.50480

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