THE RELATIONSHIP BETWEEN HEART RATE VARIABILITY AND CARDIOVASCULAR RISK FACTORS IN HYPERTENSIVE PATIENTS

Yıl 2018, Cilt: 8 Sayı: 2, 303 - 310, 29.06.2018

Alper Çil Efe Edem Özhan Göldeli

https://doi.org/10.31832/smj.375106

Cited By: 1

Öz

Objective:
Although many cardiovascular risk factors are well known at present, additional
number of cardiovascular mortality predictors are needed because of the fact that
cardiovascular diseases are also observed in patients who do not have any well
described risk factors. The aim of current study is to analyse the relationship
between heart rate, heart rate variability and novel cardiovascular risk
factors.


Materials and Methods: A total of 63 consecutive patients were included in this
study. Aortic pulse wave velocity of all patients was calculated with SphygmoCor
(AtCorMedical Instruments) tonometry device. Average heart rate, maximum and
minimum heart rate, average RR period, 24 hours triangle index, the mean of the standard deviations for all
R-R intervals, standard deviation of all R-R intervals in successive
five-minute epochs, and root-mean square differences of successive R-R
intervals were obtained by using time dependent heart rate analyse obtained
from 24 hours ECG records. 


Results: Mean heart rate of the study population was 84.3±9.2 bpm. Mean pulse wave
velocity of the study population was 5.7±0.4 m/sec and mean carotid intima-media
thickness of the study population was 0.87±0.09 mm. Patients were classified into
two groups according to median night heart rate (≤65 bpm vs. >66 bpm). No significant
difference was observed between two groups in terms of age, gender, pulse wave
velocity, and cholesterol levels however, a significant difference was observed
between groups in terms of carotid intima-media thickness. 


Conclusion: We suggest that heart rate and heart rate variability should be
used as a non-invasive method, which can be measured without excessive costs in
daily clinical practice.

Anahtar Kelimeler

Heart rate variability, Electrocardiography, Risk of cardiovascular disease

Hipertansif Hastalarda Kalp Hızı Değişkenliği ile Kardiyovasküler Risk Faktörlerinin İlişkisi

Öz

Amaç:
Birçok kardiyovasküler risk faktörünün bilinmesine rağmen, risk faktörleri
olmayan hastalarda da kardiyovasküler hastalıkların gözlenmesi nedeniyle yeni
bir takım öngördürücülere ihtiyaç duyulmaktadır. Çalışmamızın amacı kalp hızı
ve kalp hızı değişkenliğinin yeni geliştirilmiş olan kardiyovasküler risk
faktörleri ile ilişkisini değerlendirmektir.


Gereç ve Yöntemler: Çalışmaya toplam 63 ardışık hasta dahil edildi. SphygmoCor
(AtCorMedical Instruments) markalı tonometri cihazı ile tüm hastaların aortik
nabız dalga hızları hesaplandı. Alınan 24 saatlik elektrokardiyografi kayıtlarından
yapılan zaman bağımlı kalp hızı analizlerinde ortalama kalp hızı maksimum ve
minimum kalp hızları, ortalama RR süreleri, 24 saat triangle index, the mean of the standard deviations for all
R-R intervals, standard deviation of all R-R intervals in successive
five-minute epochs ve root-mean square differences of successive R-R
intervals değerleri elde edildi. Kalp hızı ve kalp hızı
değişkenliği ile yeni geliştirilmiş olan kardiyovasküler risk arasındaki ilişki
araştırıldı. 

Bulgular: Çalışma grubunun nabız ortalaması 84.3±9.5 vuru/dk idi. Ortalama
sistolik kan basınçları 141.7±13.5 mmHg, diyastolik kan basınçları 75.3±6.9
mmHg, nabız dalga hızı 5.73 ±0.45 m/sn, ortalama karotis intima-media
kalınlığı 0.87±0.09 mm idi. Median gecelik kalp hızına (65 vuru/dk) göre
2 gruba ayrılan hastaların yaş, cinsiyet, kolesterol düzeyleri ve nabız dalga hızları arasında
anlamlı farklılık saptanmamakla birlikte karotis intima-media kalınlığı ile gecelik kalp hızı arasında
anlamlı ilişki saptandı.


Sonuç: Kardiyovasküler hastalığı öngörmede çeşitli girişimsel olmayan tetkikler
kullanılmaktadır. Bu tetkiklerin basit olması yanında kardiyovasküler hastalığı
tahmin etmede doğruluk oranının da yüksek olması gerekmektedir. Bu açıdan
bakıldığında kalp hızı ve kalp hızı değişkenliği günlük klinik kullanımda
maliyetsiz ölçülebilen, girişimsel olmayan bir yöntem olarak önem kazanmaktadır
ve yakın gelecekte kullanımı umut vadetmektedir.

Anahtar Kelimeler

Kalp Hızı Değişkenliği, Elektrokardiyografi, Kardiyovasküler Hastalık Riski

Kaynakça

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