Ankilozan Spondilitli Hastalarda Retina ve Koroid Kalınlığının Sedimentasyon Hızı ile İlişkisi

Yıl 2018, Cilt: 8 Sayı: 4, 775 - 781, 30.12.2018

İsa Yuvacı , Mahmut Atum , Emine Pangal Nurettin Bayram Emel Güler Fatmagül Ülkü Demir

https://doi.org/10.31832/smj.470668

Öz

Amaç:
Sistemik olarak aktif, göz tutulumu bulunmayan Ankilozan Spondiltlilerde (AS)
eritrosit sedimentasyon hızı (ESR) ile retina ve kororidal kalınlık bağlantısının
araştırılması.

Gereç
ve Yöntem: Romatoloji kliniğinde AS tanısı ile takip edilen, göz bölümüne
konsülte edilen, göz tutulumu bulumayan kişilerile demografik olarak bunlara
benzer göz kliniğinde takip edilen normal kişiler çalışmaya alındı. Kan testi
sonrası göz muayenesi ve OCT ölçümü 1 saat içerisinde yapıldı. Merkezi makula
kalınlığı(CMT), merkezi subfoveal koroid kalınlığı(CSCT), retina sinirlifi
kalınlığı(RNFL), OCT cihazı ile ölçüldü. Çıkan sonuçlar, SPSS programı ile
kontrol grubu ve AS’liler arasında ve AS’liler de kendi içinde, sedimentasyon
hızına göre değerlendirildi.

Bulgular ve Sonuç: AS’li hastaların
ortalama yaşı 35.8 ve ortalama hastalık süreleri 6.38 yıl idi. Ortalama ESR
seviyesi 18.2 mm/H idi. Sırasıyla ortalama olarak CSCT 321.00µ, CMT 255.56µ ve RNFL 99.87µ kalınlığında idiler. Kontrol grubunda ise
sırasıyla bu değerler 317.21µ,
259.02µ ve
100.98µ kalınlığında idi. CSCT,
CMT ve RNFL kalınlıkları bakımından AS'liler ve normal grup arasında fark
izlenmedi. AS'li hastalar ESR seviyesine göre kendi aralarında kıyaslandığında
ise bu verilerin hiçbirinin ESR ile bağlantısı kurulamadı. Çalışmamızda göz
tutulumu olmayan, sistemik olarak aktif AS’lilerde ESR seviyesi ile retina ve
koroid kalınlık bağlantısı araştırıldı ve herhangi bir bağlantı kurulamadı.

Anahtar Kelimeler

ESR, AS, koroid

The Investigation of the Relationship Between Retinal and Choroidal Thickness By Sedimentation Rate for Patients with Ankylosing Spondylitis

Öz

Objective: The investigation of the relationship
between retinal and choroidal thickness with Erythrocyte Sedimentation Rate(ESR)
for systematically active ankylosing spondylitis patients without ocular
involvement.

 

Materials and Methods:
Among the patients being followed-up with a diagnosis of AS in the rheumatology
clinic, those with proper conditions who required eye consultation and normal
people demographically similar to these patients being inspected in the eye
section were included in the study. After blood test, eye examination and OCT
measurements were performed within one hour. Central macular thickness(CMT), central
subfoveal choroidal thickness(CSCT), and retinal nerve fiber layer(RNFL)
thickness were measured with OCT. Results were obtained with SPSS evaluated for
patients with AS compared to normal people and within the group with AS according
to ESR level.

 

Results and Conclusion: The mean age of
participating patients was 35.8, mean of disease duration was 6.38 years and
average ESR level was 18.2mm/H. Average CSCT thickness of patients with AS was
321.00µ,
average CMT thickness was 255.56µ and
average RNFL thickness was 99.87µ. CSCT,
CMT and RNFL thickness of control group
participants were as follows: 317.21µ, 259.02µ and 100.98µ. No significant difference was observed with
regard to CSCT, CMT and RNFL thickness values between patients with AS and the
control group. When patients with AS were evaluated
among themselves, a connection between ESR level and CSCT, CMT and RNFL
thickness could not be established. In our
study, we could not establish a connection between ESR level and CSCT, CMT, and
RNFL.

Anahtar Kelimeler

ESR, AS, choroid

Kaynakça

• Bridgen ML. Clinical utility of the eryhrocyte sedimentation rate. Am. Fam Phisician. 60: 1443-50. 1999
• Sox HC Jr, Liang MH. The erythrocyte sedimentation rate guidelines for rational use. Annals of Internal Medicine. 104: 515-23. 1986
• Ji SX, Yin XL, Yuan RD, Zheng Z, Huo Y, Zou H. Clinical features of ankylosing spondylitis associated with acute anterior uveitis in Chinesepatients. Int J Ophthalmol.5:164-6. 2012
• Chan CC, Inrig T, Molloy CB, Stone MA, Derzko-Dzulynsky L. Prevalence of inflammatory back pain in a cohort of patients with anterior uveitis. Am J Ophthalmol.153:1025-30. 2012
• Chang JH,McCluskey PJ, Wakefield D. Acute anterior uveitis and HLA-B27. Surv Ophthalmol.; 50(4):364–88. 2005
• Brophy S, Pavy S, Lewis P, Taylor G, Bradbury L, Robertson D, Lovell C, Calin A. Inflammatory eye, skin and bowel disease in spondyloarthritis: Genetic, phenotypic and environmental factors. J Rheumatol.28: 2667-73. 2001
• Fernández-Melón J, Muñoz-Fernández S, Hidalgo V, Bonilla-Hernán G, Schlincker A, Fonseca A, Vieitez J, Martín-Mola E.Uveitis in the initial clinical manifestation in patients with spondyloartropathies. J Rheumatol.31:524-7. 2004
• Kola M, Kalkisim A, Karkucak M, Turk A, Capkin E, Can I, Serdar OF, Mollamehmetoglu S, Ayar A. Evaluation of choroidal thickness in ankylosing spondylitis using optical coherence tomography. Ocul Immunol Inflamm.22(6):434-8. 2014
• Ayhan Tuzcu E, Ustun N, Ilhan N, Yagiz E, Daglioglu MC, Coskun M, Ilhan O, Keskin U, Yengil E. Peripapillary retinal nerve fiber layer and ganglion cell-inner plexiform layers thickness in ankylosing spondylitis. Ocul Immunol Inflamm. 22(6):429-33. 2014
• Spaide RF, Koizumi H, Pozzoni MC. Enhanced depth imaging spectral-domain optical coherence tomography. Am J Ophthalmol.146:496–500. 2008
• R. Chakraborty, S. A. Read, and M. J. Collins, “Diurnal variations in axial length, choroidal thickness, intraocular pressure, and ocular biometrics” Investigative Ophthalmology and Visual Science.52(8) 5121–5129. 2011
• Shulman S, Goldenberg D,Habot-Wilner Z, et al. Optical coherence tomography characteristics of eyes with acute anterior uveitis. Isr Med Assoc J.14:543–546. 2012
• Traill A, Stawell R, Hall A, Zamir E. Macular thickening in acute anterior uveitis. Ophthalmology.114:402. 2007
• Szepessy Z, Barsi Á, Németh J. Macular Changes Correlate with the Degree of Acute Anterior Uveitis in Patients with Spondyloarthropathy. OculImmunolInflamm. 24:1-6. 2015
• Buttanrı İB, Kurtuluş D, Serin D. EyeInvolvement in Patients with Ankylosing Spondylitis. Glo-Kat 2014;9:267-269
• Fujiwara T., Imamura Y., Margolis R., Slakter JS., Spaide RF., “Enhanced depth imaging optical coherence tomography of the choroid in highly myopic eyes,” American Journal ofOphthalmology.148; 3.445–450. 2009
• Imamura Y., Fujiwara T., Margolis R., Spaide R. F., “Enhanced depth imaging optical coherence tomography of the choroid in central serous chorioretinopathy,” Retina. 29(10)1469–1473, 2009
• Spaide R. F. “Age-related choroidal atrophy,” American Journalof Ophthalmology. 147(5) 801–810. 2009
• Usui S, Ikuno Y, Akiba M, Maruko I, Sekiryu T, Nishida K, Iida T. Circadian changes in subfoveal choroidal thickness and the relationship with circulatory factors in healthy subjects. Invest Ophthalmol Vis Sci.53(4):2300–7. 2012
• Dervişoğulları MS, Totan Y, Tenlik A, Yuce A. Effects of cigarette smoking on choroidal and retinal thickness and ocular pulse amplitude. CutanOcul Toxicol.34(3):217-221. 2015
• Vural AD, Kara N, Sayin N, Pirhan D, Ersan HBA. “Choroidal thickness change safter a single administration of coffee in healthy subjects,” Retina, 34(6) 1223–1228. 2014
• Fong AHC, Li KKW, Wong D. Choroidal evaluation using enhanced depth imaging spectral domain optical coherence tomography in Vogt- Koyanagi-Harada disease. Retina, 31: 502–509. 2011
• Nakayama M, Keino H, Okada AA, Watanabe T, Taki W, Inoue M, Hirakata A: Enhanced depth imaging optical coherence tomography of the choroid in Vogt-Koyanagi-Harada disease. Retina.32(10):2061–2069. 2012
• Maruko I, Iida T, Sugano Y, Oyamada H, Sekiryu T, Fujiwara T, Spaide RF: Subfoveal choroidal thickness after treatment of Vogt-Koyanagi-Haradadisease. Retina.31(3):510–517. 2011
• Aoyagi R, Hayashi T, Masai A, Mitooka K, Gekka T, Kozaki K, Tsuneoka H: Subfoveal choroidal thickness in multiple evanescent white dot syndrome. ClinExpOptom.,95:212–217. 2012
• Kim M, Kim H, Kwon HJ, Kim SS, Koh HJ, Lee SC: Choroidal thickness in Behcet's uveitis: an enhanced depth imaging-optical coherence tomography and its association with angiographic changes. Invest Ophthalmol Vis Sci.54:6033–6039. 2013
• Karampelas M, Sim DA, Keane PA, Zarranz-Ventura J, Patel PJ, Tufail A, Westcott M, Lee R, Pavesio CE: Choroidal assessment in idiopathic panuveitis using optical coherence tomography. Graefes Arch Clin Exp Ophthalmol .251(8):2029–2036. 2013
• Géhl Z, Kulcsár K, Kiss HJ, Németh J, Maneschg OA, Resch MD. Retinal and choroidal thickness measurements using spectral domain optical coherence tomography in anterior and intermediate uveitis. BMC Ophthalmol. 30;14:103. 2014