Akut miyeloid lösemide FLT3 mutasyonlarının prognozuna ve diğer genetik değişikliklerle etkileşimlerine genel bakış

Yıl 2024, Cilt: 14 Sayı: 4, 433 - 434, 31.12.2024

Aynur Dağlar Aday , Ayşe Gül Bayrak Tokaç

https://doi.org/10.31832/smj.1595597

Öz

Acute Myeloid Leukemia (AML) is one of the most aggressive hematological malignancies. It has a highly heterogeneous genetic background and complex clonal evolution. In this letter, we emphasized the prognostic importance of a crucial biomarker in acute myeloid leukemia (AML) – the Fms - like tyrosine kinase 3 (FLT3), a receptor tyrosine kinase that plays a significant role in several cellular signalling processes. FLT3 is found on hematopoietic stem cells and early progenitor cells. After binding to its ligand, activated FLT3 triggers intracellular kinase, leads to cellular proliferation, and inhibits differentiation and apoptosis.

Anahtar Kelimeler

FLT3, mutasyon, akut myeloid lösemi

Overview of Prognosis of FLT3 Mutations and Interactions with Other Genetic Alterations in Acute Myeloid Leukemia

Öz

Acute Myeloid Leukemia (AML) is one of the most aggressive hematological malignancies. It has a highly heterogeneous genetic background and complex clonal evolution. In this letter, we emphasized the prognostic importance of a crucial biomarker in acute myeloid leukemia (AML) – the Fms - like tyrosine kinase 3 (FLT3), a receptor tyrosine kinase that plays a significant role in several cellular signalling processes. FLT3 is found on hematopoietic stem cells and early progenitor cells. After binding to its ligand, activated FLT3 triggers intracellular kinase, leads to cellular proliferation, and inhibits differentiation and apoptosis.

Anahtar Kelimeler

FLT3, mutation, acute myeloid leukemia

Kaynakça

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