EVALUATING THE EFFECT OF THE CYP1A2 rs762551 GENE POLYMORPHISM ON ARROWHEAD AGILITY DRILL TEST PERFORMANCE IN PHYSICALLY ACTIVE YOUNG MEN

Yıl 2025, Cilt: 23 Sayı: 2, 149 - 157, 30.06.2025

Esra Yildiz , Mesut Cerit , Tolga Polat , Murat Anilir , Selin Yıldırım Tuncer

https://doi.org/10.33689/spormetre.1616315

Öz

The purpose of this study is to determine the different results and genotype distributions associated with the effect of CYP1A2 rs762551 gene polymorphisms on the development rates of arrowhead agility drill test performance after six weeks of training in active adult males. The research population comprised of 54 healthy young men aged 19 to 24 from the Faculty of Sports Sciences who freely participated. The arrowhead agility drill test was administered at the beginning and end of the 6-week trial to assess anaerobic performance. There was no statistically significant difference between the three genotypes, according to the comparison of the subject group's pre- and post-test results for the arrowhead agility drill test for both right and left variables. The genotype frequencies for the CYP1A2 gene polymorphism are as follows: AA 29.78%, AC 63.82%, and CC 6.40%. In conclusion, while our study's sample size was not as large as hoped, the findings on the interactions revealed by CYP1A2 gene polymorphisms impacting athletic achievement are similar with those from another research. Given that the performance-enhancing effects of caffeine on athletes may be influenced by several genes and multifactorial variations, comprehensive study is essential to enhance the predictability of techniques connected to CYP1A2 gene variants.

Anahtar Kelimeler

CYP1A2 , caffeine intake , physical activity

AKTİF YETİŞKİN ERKEKLERDE CYP1A2 rs762551 GEN POLİMORFİZMİNİN ARROWHEAD ÇEVİKLİK YETENEK TEST PERFORMANSI ÜZERİNDEKİ ETKİLERİNİN İNCELENMESİ

Öz

Bu çalışma, aktif yetişkin erkeklerde altı haftalık antrenmanın ardından CYP1A2 rs762551 gen polimorfizmlerinin arrowhead agility drill testi performans gelişim oranlarına etkilerinin açığa çıkardığı farklı sonuçlar ve genotip dağılımların belirlenmesi amaçlanmıştır Araştırmanın evrenini Spor Bilimleri Fakültesi'nden gönüllü olarak katılan, yaşları 19-24 arasında değişen 54 sağlıklı genç erkek oluşturmuştur. Anaerobik performansı değerlendirmek için 6 haftalık çalışmanın başlangıcında ve sonunda arrowhead çeviklik yetenek testi yapıldı. Denek grubunun arrowhead çeviklik yetenek testine ilişkin ön test ve son test sonuçları hem sağ hem de sol değişkenler açısından değerlendirildiğinde, üç genotip arasında istatistiksel olarak anlamlı farklılık bulunmamıştır. CYP1A2 gen polimorfizminin genotip frekans dağılımı şu şekildedir: AA %29,78, AC %63,82 ve CC %6,40. Sonuç olarak, çalışmamızdaki örneklem büyüklüğü arzu edilen sayıda olmamasına rağmen atletik başarıyı etkileyen CYP1A2 gen polimorfizmlerinin açığa çıkardığı etkileşimlerde gözlemlediğimiz sonuçlar bazı araştırmaların bulgularıyla benzerlik göstermektedir. Bu çerçevede; kafeinin sporcular üzerindeki performans artırıcı etkileri çok gen ve çok faktörlü varyasyonlara bağlı olabileceği gerçeği göz önüne alınarak, CYP1A2 gen varyantlarına ilişkin yaklaşımların daha öngörülebilir olabilmesi için geniş kapsamlı araştırmalar yapılmasına ihtiyaç olduğu değerlendirilmektedir.

Anahtar Kelimeler

CYP1A2 , kafein alımı , fiziksel aktivite

Kaynakça

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