İleri Yaşlılarda Uygunsuz İlaç Kullanım Sıklığı

Öz

Amaç: Bu çalışmanın amacı toplum kökenli ileri yaşlılarda potansiyel uygunsuz ilaç, antikolinerjik etkili ilaç ve ilaç-ilaç etkileşimine neden olan ilaçların kullanım sıklığının saptanmasıdır. Yöntem: Kesitsel bir çalışmadır. Örneklem büyüklüğü 384 bulunmuştur. Türkiye geneli kendi evinde ya da akrabaları yanında yaşayan ileri yaşlılar yaşadıkları ortamda ziyaret edilmiştir. Kullandıkları ilaçlar arasında potansiyel uygunsuz ilaç, antikolinerjik ilaç ve ilaç-ilaç etkileşimine neden olan ilaçların analizi yapılmış ve uygunsuz ilaç kullanımı olarak adlandırılmıştır. Bulgular: Türkiye geneli 549 ileri yaşlı ile görüşülmüştür. Görüşülen ileri yaşlıların %38,7’si (n=213) erkek olup; katılımcıların median yaşı 88,0‘dır (min=85 max=102). İleri yaşlıların %72,3 (n=397)’ ünde uygunsuz ilaç kullanımı saptanmıştır. Uygunsuz ilaç kullanım median değeri üç (1,0-6,0) bulunmuştur. İleri yaşlılar arasında potansiyel uygunsuz ilaç, ilaç-ilaç etkileşimine neden olan ilaçlar ve antikolinerjik ilaç kullanım sıklığı sırası ile %65,0, %54,2 ve %51,3 bulunmuştur. Kullanılan ilaç sayısı arttıkça uygunsuz ilaç kullanımı istatistiksel olarak anlamlı düzeyde artmıştır (r=0,805, p=0,0001). Sonuç: İleri yaşlılar arasında uygunsuz ilaç kullanımı yüksektir. İleri yaşlılar arasında uygunsuz ilaç kullanımı sağlık profesyonelleri tarafından dikkate alınmalıdır.

Anahtar Kelimeler

• en yaşlı
• polifarmasi
• ilaç ilişkili yan etkiler ve istenmeyen reaksiyonlar
• potansiyel olarak uygunsuz ilaç listesi
• kolinerjik antagonistler

The Frequency of Inappropriate Medication Use Among the Oldest Old People

Öz

Objective: This study aims to determine the frequency of use of potentially inappropriate medication, anticholinergic medication, and medications that cause drug-drug interactions in community-based oldest old people. Method: It was a cross-sectional study. The sample size was 384. The oldest old people living in their own homes or with relatives throughout Türkiye were visited. Among the medications used by the oldest old people, potentially inappropriate medication, anticholinergic medication, and medications causing drug-drug interactions were analyzed and named as inappropriate medication use. Results: The number of the oldest old interviewed in Türkiye was 549. The rate of males among the oldest old people was 38.7% (n=213); the median age was 88.0 (min=85, max=102). Inappropriate medication use was found in 72.3% (n=397) of the oldest old people. The median value of inappropriate medication use was three (1.0-6.0). The usage frequency of potentially inappropriate medication, medications causing drug-drug interaction, and anticholinergic medication among the oldest old people was 65.0%, 54.2%, and 51.3%, respectively. As the number of medications used increased, inappropriate medication use increased statistically significantly (r=0.805, p=0.0001). Conclusion: Inappropriate medication use is high among the oldest old people. Inappropriate medication use among the oldest old people should be considered by healthcare professionals.

Anahtar Kelimeler

• oldest old
• polypharmacy
• drug-related side effects and adverse reactions
• potentially inappropriate medication list
• cholinergic antagonists

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