Yıl 2020, Cilt 29 , Sayı 2, Sayfalar 381 - 442 2020-04-11

OBEZ HASTALARDA ANTİMİKROBİYAL İLAÇ DOZLARI

Melda BAHAP [1] , Pınar BAKIR EKİNCİ [2] , Aygin BAYRAKTAR EKİNCİOĞLU [3] , Kutay DEMİRKAN [4]


Obezite çok sayıda enfeksiyon hastalığı ile yakından ilişkilidir. Bu enfeksiyonların yönetiminde obez bireylerde görülen fizyolojik değişiklikler sebebiyle zorluklar yaşanmaktadır. Bu fizyolojik değişiklikler ilaç farmakokinetiği ve farmakodinamiğinin değişmesine sebep olmaktadır. Farmakokinetik olarak dağılım hacmi ve ilaç klirensi; farmakodinamik olarak ise, minimum inhibitör konsantrasyon ve eğri altında kalan alan önemli rol oynamaktadır. Sonuç olarak normal kilolu hastalar için verilen ilaç dozları obez hastalarda ya yetersiz tedavi dozu ya da nefrotoksisite, hepatotoksisite gibi istenmeyen durumlara sebep olmaktadır. Özellikle vücut ağırlığına göre dozları belirlenen ilaçlarda hesaplanan doz gerçek vücut ağırlığına dayandığından bazı ilaçların dozlarında değişiklik yapılması gerekebilmektedir. Bunun için çeşitli vücut ölçüsü tanımlayıcıları – toplam vücut ağırlığı, yağsız vücut ağırlığı, düzeltilmiş vücut ağırlığı, ideal vücut ağırlığı, beden kitle indeksi, vücut yüzey alanı – geliştirilmiş ve formüle edilmiştir. Obez bireylerde hangi yöntemin kullanılacağı ilacın fizikokimyasal özelliklerine göre belirlenmektedir.

Bu derleme ile obez hastalarda farmakokinetik ve farmakodinamik değişimlerin incelenmesi ve antibiyotik, antifungal ve antiviral ilaç dozlarının doğru ve akılcı şekilde sağlanması için doz değişikliklerinin gerekli olup olmadığı, hangi vücut büyüklüğü tanımlayıcısının kullanılması gerektiği ile ilgili güncel bilgilerin sunulması amaçlanmaktadır. 

Obezite, Farmakokinetik, Farmakodinamik, Doz, Antibiyotik, Antifungal, Antiviral, Klinik eczacı
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Birincil Dil tr
Konular Sağlık Bilimleri ve Hizmetleri
Yayımlanma Tarihi Kasım Aralık 2019
Bölüm Derleme
Yazarlar

Orcid: 0000-0003-1392-1135
Yazar: Melda BAHAP (Sorumlu Yazar)
Kurum: Hacettepe Üniversitesi Eczacılık Fakültesi Klinik Eczacılık Anabilim Dalı
Ülke: Turkey


Orcid: 0000-0003-0694-6078
Yazar: Pınar BAKIR EKİNCİ
Kurum: Hacettepe Üniversitesi Eczacılık Fakültesi Klinik Eczacılık Anabilim Dalı
Ülke: Turkey


Orcid: 0000-0002-3481-0074
Yazar: Aygin BAYRAKTAR EKİNCİOĞLU
Kurum: Hacettepe Üniversitesi Eczacılık Fakültesi Klinik Eczacılık Anabilim Dalı
Ülke: Turkey


Orcid: 0000-0002-6427-5826
Yazar: Kutay DEMİRKAN
Kurum: Hacettepe Üniversitesi Eczacılık Fakültesi Klinik Eczacılık Anabilim Dalı
Ülke: Turkey


Destekleyen Kurum 07-10-2019
Tarihler

Yayımlanma Tarihi : 11 Nisan 2020

Bibtex @derleme { sted598625, journal = {STED / Sürekli Tıp Eğitimi Dergisi}, issn = {1300-0853}, eissn = {2148-5348}, address = {}, publisher = {Türkiye Tabipleri Birliği}, year = {2020}, volume = {29}, pages = {381 - 442}, doi = {10.17942/sted.598625}, title = {OBEZ HASTALARDA ANTİMİKROBİYAL İLAÇ DOZLARI}, key = {cite}, author = {BAHAP, Melda and BAKIR EKİNCİ, Pınar and BAYRAKTAR EKİNCİOĞLU, Aygin and DEMİRKAN, Kutay} }
APA BAHAP, M , BAKIR EKİNCİ, P , BAYRAKTAR EKİNCİOĞLU, A , DEMİRKAN, K . (2020). OBEZ HASTALARDA ANTİMİKROBİYAL İLAÇ DOZLARI. STED / Sürekli Tıp Eğitimi Dergisi , 29 (2) , 381-442 . DOI: 10.17942/sted.598625
MLA BAHAP, M , BAKIR EKİNCİ, P , BAYRAKTAR EKİNCİOĞLU, A , DEMİRKAN, K . "OBEZ HASTALARDA ANTİMİKROBİYAL İLAÇ DOZLARI". STED / Sürekli Tıp Eğitimi Dergisi 29 (2020 ): 381-442 <https://dergipark.org.tr/tr/pub/sted/issue/53712/598625>
Chicago BAHAP, M , BAKIR EKİNCİ, P , BAYRAKTAR EKİNCİOĞLU, A , DEMİRKAN, K . "OBEZ HASTALARDA ANTİMİKROBİYAL İLAÇ DOZLARI". STED / Sürekli Tıp Eğitimi Dergisi 29 (2020 ): 381-442
RIS TY - JOUR T1 - OBEZ HASTALARDA ANTİMİKROBİYAL İLAÇ DOZLARI AU - Melda BAHAP , Pınar BAKIR EKİNCİ , Aygin BAYRAKTAR EKİNCİOĞLU , Kutay DEMİRKAN Y1 - 2020 PY - 2020 N1 - doi: 10.17942/sted.598625 DO - 10.17942/sted.598625 T2 - STED / Sürekli Tıp Eğitimi Dergisi JF - Journal JO - JOR SP - 381 EP - 442 VL - 29 IS - 2 SN - 1300-0853-2148-5348 M3 - doi: 10.17942/sted.598625 UR - https://doi.org/10.17942/sted.598625 Y2 - 2019 ER -
EndNote %0 STED / Sürekli Tıp Eğitimi Dergisi OBEZ HASTALARDA ANTİMİKROBİYAL İLAÇ DOZLARI %A Melda BAHAP , Pınar BAKIR EKİNCİ , Aygin BAYRAKTAR EKİNCİOĞLU , Kutay DEMİRKAN %T OBEZ HASTALARDA ANTİMİKROBİYAL İLAÇ DOZLARI %D 2020 %J STED / Sürekli Tıp Eğitimi Dergisi %P 1300-0853-2148-5348 %V 29 %N 2 %R doi: 10.17942/sted.598625 %U 10.17942/sted.598625
ISNAD BAHAP, Melda , BAKIR EKİNCİ, Pınar , BAYRAKTAR EKİNCİOĞLU, Aygin , DEMİRKAN, Kutay . "OBEZ HASTALARDA ANTİMİKROBİYAL İLAÇ DOZLARI". STED / Sürekli Tıp Eğitimi Dergisi 29 / 2 (Nisan 2020): 381-442 . https://doi.org/10.17942/sted.598625
AMA BAHAP M , BAKIR EKİNCİ P , BAYRAKTAR EKİNCİOĞLU A , DEMİRKAN K . OBEZ HASTALARDA ANTİMİKROBİYAL İLAÇ DOZLARI. STED. 2020; 29(2): 381-442.
Vancouver BAHAP M , BAKIR EKİNCİ P , BAYRAKTAR EKİNCİOĞLU A , DEMİRKAN K . OBEZ HASTALARDA ANTİMİKROBİYAL İLAÇ DOZLARI. STED / Sürekli Tıp Eğitimi Dergisi. 2020; 29(2): 442-381.