HBsAg Pozitif Hastaların Trombosit/Lenfosit, Trombosit/Nötrofil, Nötrofil/Lenfosit ve PLT/MPV Düzeylerinin Araştırılması

Yıl 2020, Cilt: 29 Sayı: 4, 276 - 280, 01.09.2020

Arzu Şahin , Filiz Bayar , Eda Dokumacıoğlu

https://doi.org/10.17942/sted.758363

Öz

Amaç: Hepatit B virüs (HPV) enfeksiyonu tüm dünyada olduğu gibi ülkemizde de oluşturduğu tablolar ve sonuçlar bakımından önemli mortalite ve morbidite sebeplerinden biridir. Bu çalışmada, hepatit B yüzey antijen (HBsAg) pozitif hastalarda Trombosit/Lenfosit (TLO), Trombosit/Nötrofil (TNO), Nötrofil/Lenfosit (NLO) ve PLT/MPV oranlarının değerlendirilmesi amaçlanmıştır.
Gereç ve Yöntemler: Çalışmaya Uşak Eğitim ve Araştırma Hastanesi polikliniklerine başvuran, HBsAg pozitifliği olan, tam kan sayımı parametreleri çalışılmış 200 hasta, kontrol grubu olarak ise aynı hastaneye başvuran ve tam kan sayımı parametreleri çalışılmış HBsAg’si negatif olan 200 hasta dahil edilmiştir.
Bulgular: HBsAg-pozitif grupta lenfosit değerleri kontrol grubuna göre istatistiksel olarak anlamlı derecede düşük bulundu (p<0.05). HBsAg-pozitif grupta MPV değerleri kontrol grubuna göre istatistiksel olarak anlamlı derecede yüksek bulundu (p<0.05). Hem hasta grubunda hem de kontrol grubunda trombosit sayısı ile MPV arasında pozitif korelasyon vardı (sırasıyla r=0.34, p=0.01 ve r=0.32, p=0.01).
Tartışma ve Sonuç: HBV ile enfekte bireylerde inflamasyon düzeyinin belirlenmesi hastaların takibi yönünden önemlidir Daha büyük sayıdaki hasta popülasyonları ile çok merkezli, prospektif olarak yapılacak çalışmalar hepatit B ile NLO, PLO, TNO ve PLT/MPV ilişkisi konusunda daha aydınlatıcı fikirler verebilir.

Anahtar Kelimeler

Hepatit B virüs, Nötrofil/Lenfosit, Platalet/Lenfosit

Examination of Platelet/Lymphocyte, Platelet/Neutrophil, Neutrophil/Lymphocyte and PLT/MPV Levels of HBsAg Positive Patients

Öz

Abstrac
Introductıon: Hepatitis B virus (HPV) infection is one of the important causes of mortality and morbidity in terms of the tables and results it creates in our country as well as all over the world. The aim of study, Platelet/Lymphocyte (PLR), Platelet/Neutrophil (PNR), Neutrophil/Lymphocyte (NLR) and PLT/MPV ratio values were retrospectively evaluated in patients with positive hepatitis B surface antigen (HBsAg).
Material and Methods: 200 patients who applied to Uşak Training and Research Hospital outpatient clinics who had HBsAg positivity, whose complete blood count parameters were studied, and as control group, 200 patients who applied to the same hospital with negative HBsAg, whose complete blood count parameters were studied were included in this study.
Results: Lymphocyte values were significantly lower in the HBsAg-positive group compared to the control group (p<0.05). MPV values were significantly higher in HBsAg-positive group compared to the control group (p<0.05). There was a positive correlation between platelet count and MPV in both patient group and control group (r=0.34, p=0.01 and r=0.32, p= 0.01, respectively).
Dıscussıon and Conclusıon: Determining the level of inflammation in individuals infected with HBV is important for the follow-up of patients. Multi-centered, prospective studies with larger patient populations can provide more enlightening ideas about the relationship between hepatitis B and NLR, PLR, PNR and PLT/MPV.

Anahtar Kelimeler

Hepatitis B virus, Neutrophil/Lymphocyte, Platelet/Lymphocyte

Kaynakça

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