Biyouyumlu Hidrojeller: Sentezi ve Jelleşme Üzerinde Çözücü Etkisi

Öz

Son yıllarda biyouyumlu hidrojellere olan ilgi artmıştır. Bu çalışmada biyouyumlu bir materyal olan ve üstün hidrojel özellik gösteren poli hidroksietil metakrilat (PHEMA)’ın jel oluşum şartları araştırılmıştır. Jelleşme işleminde kullanılan çözücülerin çözme kuvvetleri oldukça etkindir. Bundan dolayı PHEMA eldesinde kullandığımız çözücü ortamı olan aseton-su karışım oranının jelleşme üzerine etkisi detaylı olarak araştırılmıştır. Araştırmanın sonucu olarak jelleşmeyi sağlayacak aseton-su karışım limitleri tespit edilmiştir. Hidrojeller su emme özelliği gösteren maddelerdir. Elde ettiğimiz PHEMA hidrojelinin su absorblama özelliği de incelenmiş ve hidrojel örneğinin kendi öz kütlesinin beş katı su emdiği gösterilmiştir.

Anahtar Kelimeler

• Biyouyumlu, hidrojeller, jelleşme, Poli hidroksietil metakrilat

BIOCOMPATIBLE HYDROGELS: SYNTHESIS, SWELLING PROPERTY AND SOLVENT EFFECT ON GELATION

Öz

Biocompatible hydrogels have an increasing interest in recent years. Poly (2-hydroxyethyl methacrylate, PHEMA) is widely studied with its biocompatible property. In this study, we have shown the gelation conditions to produce PHEMA hydrogels which have an excellent hydrogel property. Since dissolution forces by solvents are so important in gelation process, we studied the effect of solvent combination of acetone and water mixture in detail. As a result of investigation, the available acetone-water ratio limits were stated in order to obtain PHEMA hydrogels. The swelling property of PHEMA hydrogel was also shown. In our study, PHEMA samples imbibe water as much as five times of their own weight.

Anahtar Kelimeler

• Biocompatible, hydrogels, gelation, Poly (2-hydroxyethyl methacrylate)

Kaynakça

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