KİTOSAN/ter(GMA-MA-NTBA) POLİMER İLE MİKROKAPSÜL HAZIRLAMA VE KARAKTERİZASYONU

Öz

Bu çalışmada, glisidil metakrilat (GMA), maleik anhidrit (MA), N-ter-butilakrilamid (NTBA) monomerlerinden ter(GMA-MA-NTBA) polimer ilk kez sentezlenmiştir. Polimerin kimyasal yapısı FT‐IR spektroskopisi, Nükleer Manyetik Rezonans (¹H-NMR) spektroskopisi, asit sayısı ve viskozite ölçümleri ile yüzey morfolojisi taramalı elektron mikroskobu (SEM) ile çalışılmıştır. Sentezlenen ter(GMA-MA-NTBA) polimerin farklı oranlarını içeren kitosan tabanlı mikrokapsüller hazırlanmış ve yapısal kararlılığı optimize edilmiştir. Polimer-kitosan mikrokapsüller gluteraldehit çapraz bağlayıcı ile daha dayanıklı hale getirilmiştir. Mikrokapsüllerin kimyasal yapıları FT‐IR spektroskopisi ile yüzey morfolojileri SEM ile belirlenmiştir. Kitosan/ter(GMA-MA-NTBA) polimer kompozit mikrokapsüller farklı adsorpsiyon, ilaç taşıma ya da kontrollü salınım uygulamalarında denenebilir. 

Anahtar Kelimeler

• Kitosan mikrokapsül,ter-Polimer,SEM

Preparation and Characterization of Chitosan/ter(GMA-MA-NTBA) Polymer Microcapsules

Abstract

In this study, ter(GMA-MA-NTBA) polymer was synthesized from glycidyl methacrylate(GA); maleic anhydride (MA) and N-tert-butylacrylamide (NTBA) monomers for the first time. Chemical structure of the polymer was studied using FT-IR spectroscopy, Nuclear Magnetic Resonance (¹H-NMR) spectroscopy, acidic group number and viscosity measurements and its surface morphology using scanning electron microscopy (SEM). Chitosan-based microcapsules containing different ratios of the synthesized ter(GMA-MA-NTBA) polymer were prepared and their structural stability was optimized. The microcapsules were cross-linked with glutaraldehyde to make them mechanically stronger. Chemical structure of the microcapsules was determined using FT-IR spectroscopy and their surface their surface morphology using SEM. Chitosan/ter(GMA-MA-NTBA) polymer composite microcapsules can be tested in adsorption, drug delivery and controlled release applications.

Keywords

• Chitosan microcapsule,ter-Polymer,SEM

Kaynakça

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