Endocan Levels in Children with Polycystic Kidney Disease

Öz

Objective: Autosomal dominant polycystic kidney disease (ADPKD) is a common renal disorder that is characterized by hypertension and renal failure. Recently, it has been emphasized that endocan which is an endothelial dysfunction biomarker, could increase in many renal diseases. High endocan levels have also been reported in hypertensive ADPKD adult patients with renal failure. However, studies are limited on children. In this study, we investigated the serum endocan levels in normotensive ADPKD children with normal renal function.

Material and Methods: The study consisted of 20 ADPKD children without hypertension and renal failure as a patient group, and 20 healthy age- and sex-matched children as a control group. Serum endocan levels were determined by enzyme-linked immunosorbent assay techniques and compared between the two groups.

Results: The mean age of patients was 9.9±4.12 years, and the mean age of the control group was 10.2±3.83 years. There was no significant difference between the two groups in terms of gender, age, and BMI (p=0.751, p=0.813, p=0.781, respectively). The leukocyte (p=0.449), hemoglobin (p=0.337), platelets (p=0.134), serum uric acid (p=0.671) and serum creatinine (p=0.074) levels, eGFR (p=0.459) were not significantly differed between groups. The mean serum endocan level in the PKD group was 345.8±169.5 pg/ml, and in the control group was 448.61±258.2 pg/ml. Serum endocan levels did not change between groups (p=0.159).

Conclusion: Unlike the adult ADPKD patients, this study suggested that serum endocan level was normal in children with ADPKD without hypertension and renal failure.

Anahtar Kelimeler

• child
• polycystic kidney disease
• Endocan

Polikistik Böbrek Hastalığı Olan Çocukların Endocan Düzeyi

Öz

Amaç: Otozomal dominant polikistik böbrek hastalığı (ODPKB), hipertansiyon ve böbrek yetmezliği ile karakterize yaygın görülen bir böbrek hastalığıdır. Son zamanlarda endotel disfonksiyonu biyobelirteçlerinden olan endocanın birçok böbrek hastalığında artabileceği vurgulanmıştır. Böbrek yetmezliği olan hipertansif ODPKB’li erişkin hastalarda da yüksek endocan seviyeleri bildirilmiştir. Ancak, çocuklar üzerinde yapılan çalışmalar sınırlıdır. Bu çalışmada, normal böbrek fonksiyonu olan normotansif ODPKB’li çocuklarda serum endocan düzeylerini araştırdık.

Gereç ve Yöntemler: Çalışmaya, hasta grubu olarak hipertansiyonu ve böbrek yetmezliği olmayan 20 ODPBH’li çocuk ve kontrol grubu olarak yaş ve cinsiyet açısından benzer 20 sağlıklı çocuk dahil edildi. Serum endocan seviyeleri, enzime bağlı immünosorbent tahlil teknikleri ile belirlendi ve iki grup arasında karşılaştırıldı.

Bulgular: Hastaların yaş ortalaması 9.9±4.12 yıl, kontrol grubunun yaş ortalaması 10.2±3.83 yıldı. Cinsiyet, yaş ve VKİ açısından iki grup arasında anlamlı fark yoktu (sırasıyla p=0.751, p=0.813, p=0.781). Gruplar arasında Lökosit (p=0.449), hemoglobin (p=0.337), trombosit (p=0.134), serum ürik asit (p=0.671), serum kreatinin (p=0.074) seviyeleri, ve eGFR (p=0.459) düzeyleri açısından anlamlı fark bulunmadı. PKB grubunda ortalama serum endocan düzeyi 345.8±169.5 pg/ml, kontrol grubunda 448.61±258.2 pg/ml’di. Serum endocan seviyeleri gruplar arasında değişmedi (p=0.159).

Sonuç: Erişkin ODPKB hastalarından farklı olarak, bu çalışmada hipertansiyon ve böbrek yetmezliği olmayan ODPKB’li çocuklarda serum endocan düzeyinin normal olduğu saptandı.

Anahtar Kelimeler

• Çocuk
• Polikistik böbrek hastalığı
• Endocan

Kaynakça

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