Vitamin B12 and Folic Acid Levels in Patients with Breath Holding Spells

Öz

Objective: Breath holding spells are a benign, non-paroxysmal disorder observed in childhood. The pathogenesis of breath holding spells is still unclear. Dysfunction of the autonomic nervous system, iron deficiency, genetic predisposition, interleukin 1, nitric oxide and cerebral erythropoietin have been implicated in the pathogenesis. The purpose of this study was to compare vitamin B12 and folic acid levels between patients diagnosed with breath holding spells and a healthy group.

Material and Methods: Fifty-one cases diagnosed with breath holding spells in the pediatric neurology clinic were included in the study group (Group 1), and 78 healthy patients presenting to the general clinic in the control group (Group 2). Hemoglobin, hematocrit, mean erythrocyte volume, vitamin B12, folic acid, ferritin, iron, and iron binding capacity levels were compared between the study and the control groups.

Results: Mean folate levels were 18.92±12.83 (5.27-91) ng/mL in the study group and 9.95±8.92 (2-37) ng/mL in the control group. Mean B12 levels were 274.13±214.37 (75-1201) pg/mL in the study group and 408.82±194.18 (120-959) pg/mL in the control group. Statistically significant differences in both vitamin B12 and folic acid levels were observed between the groups (p=0.000 and p=0.002, respectively). No significant difference was determined between the attack groups’ (<15/month, >15/month) vitamin B12 (p=0.570) or folic acid (p=0.643) levels.

Conclusion: Based on this study, vitamin B12 and folic acid levels should be routinely evaluated in patients diagnosed with breath holding spells.

Anahtar Kelimeler

• Child
• Folic acid
• Treatment
• Vitamin B12

Katılma Nöbeti Olan Hastalarda B12 Vitamini ve Folik Asit Düzeyleri

Öz

Amaç: Katılma nöbetleri, çocukluk çağında görülen iyi huylu, paroksismal olmayan bir hastalıktır. Katılma nöbetlerinin patogenezi çok açık değildir. Patogenezde otonom sinir sistemi disfonksiyonu, demir eksikliği, genetik yatkınlık, interlökin 1, nitrik oksit ve serebral eritropoietinin sorumlu olabileceği ileri sürülmektedir. Bu çalışmada katılma nöbeti olan hastalar ile sağlıklı grup arasında B12 vitamini ve folik asit düzeylerinin karşılaştırılması amaçlandı.

Gereç ve Yöntemler: Çocuk nörolojisi kliniğinde katılma nöbeti tanısı konulan 51 olgu çalışma grubuna (Grup 1), genel pediatri kliniğine başvuran 78 sağlıklı hasta kontrol grubuna (Grup 2) alındı. Çalışma ve kontrol gruplarında hemoglobin, hematokrit, ortalama eritrosit hacmi, vitamin B12, folik asit, ferritin, demir ve demir bağlama kapasiteleri karşılaştırıldı.

Bulgular: Çalışma grubunda ortalama folat düzeyi 18.92±12.83 (5.27-91) ng/mL, kontrol grubunda ortalama folat düzeyi 9.95±8.92 (2-37) ng/mL, ortalama B12 düzeyi çalışma grubu 274.13±214.37 (75-1201) pg/mL, kontrol grubunda ortalama B12 düzeyi 408.82±194.18 (120-959) pg/mL’di. Gruplar arasında B12 vitamini ve folik asit düzeylerinde istatistiksel olarak anlamlı fark bulundu (p=0.000, p=0.002). Atak gruplarının (<15/ay, >15/ay) B12 vitamini (p=0.570) ve folik asit (p=0.643) düzeyleri arasında anlamlı fark saptanmadı.

Sonuç: Bu çalışma sonucunda katılma nöbeti olan hastalarda B12 vitamini ve folik asit düzeylerinin rutin olarak değerlendirilmesi gerektiği kanaatine varıldı. 

Anahtar Kelimeler

• Çocuk
• Folik asit
• Tedavi
• B12 Vitamini

Kaynakça

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