Obsesif kompulsif bozukluk ve Dikkat eksikliği hiperaktivite bozukluğu Olan Çocuk ve Ergenlerde Toxoplasma Gondii IgG Antikor Düzeylerinin Sağlıklı Kontrollerle Karşılaştırılması: Kesitsel Bir Çalışma

Öz

Amaç: Bu çalışma, T. gondi'nin IgG düzeyleri ile OKB veya DEHB belirtileri arasında bir ilişki olup olmadığını incelemek amacıyla yapılmıştır. Yöntem: OKB'si olan 42 çocuktan 31'i DEHB'si olan ve 28 sağlıklı kontrol dahil edildi. Çocuklar için Yale-Brown Obsesif-Kompulsif Ölçeği (YB-OKB), Moudsley Obsesyon-Kompulsiyon Envanteri (MOCI), Çocuk Depresyon Ölçeği (CDI) ve Çocuklarda Anksiyete İlişkili Bozuklukları Tarama Ölçeği (ÇATÖ), Turgay DSM-IV Tabanlı Çocuk Ergen Davranış Bozuklukları Tarama ve Derecelendirme Ölçeği (T-DSM-IV-S) ve Conners Ebeveyn Değerlendirme Ölçeği-48 (CPRS-48) uygulandı. Toxo gondii IgG değerleri ≥3,0 IU/mL reaktif kabul edildi. Analiz için SPSS 17.0 kullanıldı. p<.05 anlamlı kabul edildi. Bulgular: Ortalama yaş 12.1 yıl ve olguların %56,4'ü (n = 57) erkekti. Depresyon ve anksiyete belirtileri OKB ve kontrollerde benzerdi, ancak DEHB'de anlamlı derecede düşüktü. OKB'si olan tüm çocukların T. gondii'nin IgG seviyeleri negatifken (%100), kontrollerin %78,6'sı ve DEHB'si olan çocukların %90,3'ü T. gondii'nin IgG seviyeleri için negatifti. Kontrolün Toxo IgG seropozitifliği, OKB'ninkinden anlamlı derecede yüksekti. DEHB grubunda Toxo IgG düzeyleri ile Turgay DEHB-Davranış Bozukluğu alt ölçek puanları arasında pozitif korelasyon bulundu (r=.650, p<.001). OKB ve kontrol gruplarında IgG düzeyleri ile CDI, SCARED, DEHB ölçekleri arasında korelasyon saptanmadı (tüm değişkenler için p>.05). Sonuç: Bu çalışma T. gondii'nin seropozitifliği ile OKB ve DEHB arasındaki ilişkiyi doğrulamamıştır. Uzunlamasına takip ve genişletilmiş hasta serileri ile daha ileri çalışmalara ihtiyaç vardır.

Anahtar Kelimeler

• Toxoplasma gondii
• OKB
• DEHB
• çocuk

Comparison of Toxoplasma gondii IgG Antibody Levels in Children and Adolescents with Obsessive-Compulsive disorder and Attention-Deficit hyperactivity Disorder with Healthy Controls: A Cross-Sectional Study

Öz

Objective: This study was aimed to examine if there is a relation between IgG levels of T. gondi and OCD or ADHD symptoms. Method: Of 42 children with OCD, 31 with ADHD and 28 healthy control were included. Children’s Yale-Brown Obsessive-Compulsive Scale (CY-BOCS), Moudsley Obession-Compulsion Inventory (MOCI), Child Depression Inventory (CDI), and Screen of Children for anxiety related disorders (SCARED), The Turgay DSM-IV-Based Child and Adolescent Behavioral Disorders Screening and Rating Scale (T-DSM-IV-S) and The Conners’ Parent Rating Scale-48 (CPRS-48) were applied. Toxo gondii IgG values ≥3.0 IU/mL were considered to be reactive. SPSS 17.0 was used for analysis. p<.05 was accepted as significant. Results: The mean age was 12.1 years. Of 56.4% (n = 57) were boys. Depression and anxiety symptoms were similar in OCD and controls, but were significantly lower in ADHD. All children with OCD had negative (100%) for IgG levels of T. gondii, whereas 78.6% of controls and 90.3% of children with ADHD had negative for IgG levels of T. gondii. Toxo IgG seropositivity of the control was significantly higher than that of the OCD. Toxo IgG levels were positively correlated with Turgay’s ADHD-Conduct disorder subscale scores in ADHD group (r=.650, p<.001). In the OCD and the control groups, there was no correlation between IgG levels and CDI, SCARED, ADHD scales (for all variables, p>.05). Conclusion: To conclude, this study did not verify a relationship between the seropositivity of T. gondii with OCD and ADHD. Further studies are needed longitudinal follow-up and extended series of patients.

Anahtar Kelimeler

• Toxoplasma gondii
• OCD
• ADHD
• children

Kaynakça

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