Tiroid Karsinomlu Çocuk ve Adölesan Hastalarda Klinik Özelikler ve Prognoz: Tek Merkez Deneyimi

Öz

Amaç: Tiroid kanserleri çocuk ve adölesanlarda nadirdir. Çalışmada kliniğimizde takip ettiğmiz çocuk ve adölesan tiriod kanserlerinin klinik özelliklerini ve prognozunu değerlendirmeyi amaçladık.Gereç ve Yöntemler: 2004-2014 arası kliniğimizde izlenmekte olan 12 tiroid kanserli hasta çalışmaya dahil edildi.Bulgular: Papillar karsinom 9, folliküler karsinom 3 hastada saptandı. Boyun şişliği en sık başvuru nedeniydi. Bir hastada (%8) servikal lenf nodu metastazı, 1 hastada (%8) anjioinvazyon belirlendi. Akciğer metastazı saptanmadı. Total tiroidektomi 4 hastada, ipsilateral total ve kontralateral subtotal tiroidektomi 5 hastada, parsiyel tiroidektomi 2 hastada, tiroglossal kanal eksizyonu 1 hastada uygulanmıştı. I131 ablasyonu 8 hastada (%66) rezidüel veya metastatik hastalık nedeniyle uygulanmıştı. Hastalar hala remisyonda izlenmekte ve rekürrens görülmemiştir.Sonuç: Tiroid kanserlerinin çocuk ve adölesanlarda prognozu iyi olup total ve near total tiroidektomi ve takiben radyoaktif tedaviden fayda görmektedirler. Bu tedavi yaklaşımlarının kısa ve uzun dönem yan etkilerinin belirlenmesi için prospektif çalışmalara ihtiyaç vardır.

Anahtar Kelimeler

• Adölesan, Çocuk, Folliküler karsinom, Papiller karsinom, Pediatrik tiroid karsinom

The Clinical Characteristics and Outcomes of Children and Adolescents with Thyroid Carcinoma: A Single Center

Öz

Objective: Thyroid carcinomas are rare in childhood and adolescence. This study was conducted to evaluate the clinical features and outcomes in children and adolescents with thyroid carcinoma at our center. Material and Methods: Twelve children and adolescents treated for thyroid carcinoma in our departments from 2004 to 2014 were included in the study. results: Papillary carcinoma was found in 9 patients and follicular carcinoma in 3 patients. Neck swelling was the most common chief complaint. At the time of surgery, one patient (8%) had cervical lymph node metastasis, and one (8%) had angioinvasion. No patients had lung metastasis. Total thyroidectomy was performed in 4 patients, ipsilateral total and contralateral subtotal thyroidectomy in 5 patients, partial thyroidectomy in 2 patients and thyroglossal duct cyst excision in one patient. Eight patients (66%) required 131I ablation for residual or metastatic disease after thyroidectomy. At the time of this report, all patients were alive without recurrence.conclusion: According to our data, children and adolescents with thyroid carcinoma have a good prognosis and benefit from total or near-total thyroidectomy followed by radioiodine therapy. Future prospective studies are required to clarify the short- and long-term side effects of treatment approaches

Anahtar Kelimeler

• Adolescents, Children, Follicular carcinoma, Papillary carcinoma, Pediatric thyroid carcinoma

Kaynakça

1. Rapkin L, Pashankar FD. Management of thyroid carcinoma in children and young adults. Pediatr Hematol Oncol 2012;2:S39-46.
2. Vaisman F, Corbo R, Vaisman M. Thyroid carcinoma in children and adolescents-systematic review of the literature. J Thyroid Res 2011;2011:845362.
3. Kiratli PO, Volkan-Salanci B, Günay EC, Varan A, Akyüz C, Büyükpamukçu M. Thyroid cancer in pediatric age group: An institutional experience and review of the literature. J Pediatr Hematol Oncol 2013;35:93-7.
4. Zimmerman D, Hay ID, Gough IR, Goellner JR, Ryan JJ, Grant CS, et al. Papillary thyroid carcinoma in children and adults: Long-term follow-up of 1039 patients conservatively treated at one institution during three decades. Surgery 1988;104:1157-66.