Nadir Bir Genetik Hastalık: Pakionişya Konjenita Tip 2

Öz

Pakionişi konjenita (PK), nadir görülen kalıtsal ektodermal hastalık olup temel olarak hipertrofik tırnak distrofisi ve fokal palmoplantar keratoderma ile karakterizedir. Hastalık PK-1 ve PK-2 şeklinde keratin genindeki mutasyonlarla korelasyon gösteren iki klinik alt gruba ayrılmaktadır. Her ne kadar her iki grubun en belirgin klinik özelliği hipertrofik tırnak distrofisi olsa da, oral lökokeratozis genellikle PK-1’de görülürken, PK-2 ise sıklıkla tırnak distrofisi, yaygın steatosistoma, natal diş ve saç anomalileri ile prezente olur. Burada PK-2’nin klasik bulguları ile prezente olmuş ve ailesinde dört kuşağı etkilenmiş olan bir olgu sunulmuştur.

Anahtar Kelimeler

• Çocuk, Keratin, Tırnak, Pakionişi konjenita, Palmoplantar keratoderma

A Rare Genetic Disease: Pachyonychia Congenita Type 2

Öz

Pachyonychia congenita (PC) is a rare inherited ectodermal disorder characterized mainly by hypertrophic nail dystrophy and focal palmoplantar keratoderma. Pachyonychia congenita can be divided into two main clinical subtypes, PC-1 and PC-2, which are correlated with mutations in keratins. Although the most prominent clinical feature of both PC subtypes is hypertrophic nail dystrophy, oral leukokeratosis is usually seen in PC-1 while PC-2 generally presents with nail dystrophy, widespread steatocystomas, natal teeth and hair abnormalities. We report a patient with PC type II presenting with the classical features of the disease that had been transmitted for four generations

Anahtar Kelimeler

• Child, Keratin, nail, Pachyonychia congenita, Palmoplantar keratoderma

Kaynakça

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