Erken Puberte

Öz

Puberte normal zamanda ve sürede olması durumunda fizyolojik bir süreçtir. Her iki cinste de erken puberte olasılığı ile karşılaşan hekim görülen bu bulgunun gerçekten patolojik olup olmadığını, eğer gerçekten olağan dışı bir bulgu ise altta yatan nedeni, tedavi gereken bir durum olup olmadığını öncelikle sorgulamalıdır. Bu derlemede çocuk hekimlerine bu soruların yanıtına ulaşmaya yönelik bilgiler verilmeye çalışılmıştır.

Anahtar Kelimeler

• Erken puberte, premature telarş, premature pubarş

PUBERTY PRECOCİOUS

Öz

When physicians suspect precocious puberty, they should adress these questions:. Is pubertal development realy outside the normal range? What is the underlying mechanism? Is this condition realy needs treatment?

Anahtar Kelimeler

• Precocious puberty, premature thelarche, premature pubarche

Kaynakça

1. Rosenfeld RL. Puberty in the female and it’s disorders. In: Sperling MA 1.
2. eds.Pediatric Endocrinology 2nd ed. Philedelphia Saunders Company 2002: 455-519.
3. Styne DM. The testes. In:Pediatric Endocrinology 2 rd Ed. Ed by. Sperling 2.
4. M.A. Saunders. London 2002;565-673.
5. Cısterno M, Arrigo T, Pasquino A.M, Tinelli C, Antomazzi F, Bedushi L, 3.
6. Bindi G, Borrelli P, De Sanctis V, Farello G, Galluzzi F, Gargantini L,
7. Lo Presti D, Sposito M, Tatò L. Etiology and age incidance of precious puberty in girls: a multicentric study. J. Pediatr. Endocrinol Metab. 2000; 13: 695-701.
8. Bridges N. Disorders of Puberty. In: Clinical Pediatric Endocrinology 4.

9. th Ed. Ed by Brook CG, Hindmarsh P.C. London, Blackwell Science. 2001;165-79.
10. Tutar E, Ocal G, Ince E, Cin S. Premature thelarche in Kabuki make – up 5.
11. Bereket A, Turan S, Alper G, Comu S, Alpay H, Akalın F. Two patients 6.
12. with Kabuki syndrome presenting with endocrine problems. J Pediatr. Endocr. Metab. 2001; 14: 215-220.
13. Cnossen MH, Stam EN, Cooiman LC, Simonsz HJ, Stroink H, Oranje 7.
14. AP, Halley DJ, de Goede-Bolder A, Niermeijer MF, de Munick Keizer
15. Schrama S. Endocrinologic disorders and optic pathway glioms in children with neurofibromatosis type 1. Pediatrics 1997; 100: 667-670.
16. Saka N, Çetinkaya O, Günöz H, Turantan İ, Samancı A, Bundak R, Özmen 8.
17. M, Apak S, Tolun R. Hypothalamic hamartoma and precocious puberty.
18. Med. Bull İstanbul 1989;22: 307-312.
19. Nisho S, Morioka T, Fukui M, Goto Y. Surgical treatment of intractable 9.
20. seizures due to hypothalamic hamartoma. Epilepsia 1994; 35: 514-519. 10. Lee AP, Kerrigan JR. Precocious puberty. In: Pediatric endocrinology Ed.
21. by Pescovitz OH, Eugster EA. Philadelphia 2004;316-334. 11. Carel JC, Leger J. Clinical practice. Precocious Puberty .N Engl J Med
22. ; 358: 2366-2377. 12. Cassio A, Cacciari E, Zucchizi S, Balsamo A, Diegoli M, Orsini F. Central
23. precocious Puberty: clinical and imaging aspects. J Pediatr. Endocr. Metab. 2000: 13: 703-708. 13. Derter-Klein K: Precious puberty: Who has it ? Who should be treated ? J
24. Clin. Endocrinol Metab. 1999; 84: 411-414. 14. Lumbroso S, Paris F, Sultan C. McCune-Albright Syndrome:molecular
25. genetics. J. Pediatr. Endocrinol Metab. 2002; 15: 875-882. 15. Lumbroso CR, Rey S, Lohlou N, Venara M, Roulezu S, Sultan C, Limal
26. JM. Macroorchidism due to autonomous hyperfunction of sertoli cells and G (s) alpha gene mutation, an anusual expression of MAS. In: a prepuber
27. tal boy. J Clin. Endocrinol. Metab. 2001; 86: 1778-1781. 16. Roth C, Freiberg C, Zappel H, Albers N. Effective aromatase inhibition
28. by anestrozole in a patient with gonadotropin – independent precocious in McCune – Albright syndrome. J Pediatr. Endocr. Metab. 2002: 15; 945- 948. 17. Haddan N,Eugster E. An update on the treatment of precocious puberty in
29. Mc Cune - Albright syndrome end testotoxicosis.J Pediatr endocrinol and metab. 2007; 20:653-661. 18. Pasquino AM., Pucarelli I, Passeri F, Segni F, Mancini MA, Municchi G.
30. Progression of premature thelarche to central precocious puberty. J Pediatr. ; 126: 11-14. 19. İbanez L, Potau N, Dunger D, de Zegher F. Precocious pubarche in girls and development of androgen excess. J Pediatr. Endocrinol Metab. 2000;13: 1261-1263.