İdrar Yolu Enfeksiyonuna Sekonder Psödohipoaldosteronizm

Öz

Pseudohipoaldosteronizm, hiperkalemi, hiponatremi ve metabolik asidoz ile kendini gösteren ve renal tubül hücrelerinde aldesterona yanıtsızlıkla karakterize bir sendromdur. Pseodohipoaldosteronizmin sekonder formunun çoğu olguda obstrüktif üropati veya vezikoüreteral reflüye sekonder pyelonefritle ilişkili olduğu rapor edilmiştir. Ancak bu hiponatremi/hiperkalemi tablosu süt çocuklarında, üropati olmadan bile, akut piyelonefritle de oluşabilir. Burada idrar yolu anomalisi olmadan akut pyelonefrite sekonder psödohipoaldosteronizmi ve meningoseli olan 38 günlük kız hastayı sunduk.

Anahtar Kelimeler

• Akut pyelonefrit, süt çocuğu, psödohipoaldesteronizm

SECONDARY PSEUDOHYPOALDESTERONISM WITH URINARY TRACT INFECTION

Öz

Pseudohypoaldosteronism is a syndrome characterized by unrepsonsiveness to aldosterone of renal tubuli and is manifested by hyperkalemia, hyponatremia and metabolic acidosis. Most of the secondary forms of pseudohypoaldosteronism have been reported to be associated with pyelonephritis secondary to obstructive uropathy or vesicoureteral reflux. However, this hyponathremia/hyperkalemia condition may also be seen in infants with acute pyelonephritis, even in the absence of uropathy. Herein we report 38-day-old female patient with meningocele and pseudohypoaldosteronism secondary to acute pyelonephritis who had no urinary tract anomalies

Anahtar Kelimeler

• Acute pyelonephritis, infant, pseudohypoaldosteronism

Kaynakça

1. 1. Maruyama K, Watanabe H, Onigata K. Reversible secondary pseudohypoaldosteronism due to pyelonephritis. Pediatr Nephrol. 2002;17:1069- 1070.
2. 2. Gerigk M, Glanzmann R, Rascher W, Gnehm HE. Hyponatremia and hyperkalemia in acute pyelonephritis without urinary tract anomalies. Eur J Pediatr. 1995;154:582-584.
3. 3. Asano T, Abe M, Asai M, Imai T, Kamisago M, Kuwabara K, Nakajima M, Murakami M, Fujino O. Urinary tract malformation and infection with hyperkalemia and decreased fractional excretion of potassium in an infant. J Nippon Med Ech 2006;73:289-291.
4. 4. Büyükkayhan D, Köklü E, Görözen F, Kurtoğlu S, Hatipoğlu N, Gündüz Z. An endocrine problem of obstructive uropathy: pseudohypoaldosteronism. Erciyes Tıp Dergisi 2007;29:82-85.
5. 5. Ranjith G, Uthup S, Satish B, Jain N. Salt wasting disorder in the newborn. Indian J Pediatr. 2006;73:95-96.
6. 6. Klingenberg C, Hagen IJ. Transient pseudohypoaldosteronism in infants with vesicoureteral reflux. Tidsskr Nor Laegeforen 2006;126:315-317.
7. 7. Schoen EJ, Bhatia S, Ray GT, Clapp W, To TT. Transient pseudohypoaldosteronism with hyponatremia-hyperkalemia in infant urinary tract infection. J Urol. 2002;167:680-682.
8. 8. Watanabe T. Reversible secondary pseudohypoaldosteronism. Pediatr Nephrol. 2003;18:486.

9. 9. Melzi ML, Guez S, Sersale G, Terzi F, Secco E, Marra G, Tirelli AS, Assael BM. Acute pyelonephritis as a cause of hyponatremia/hyperkalemia in young infants with urinary tract malformations. Pediatr Infect Dis J. 1995;14:56-59.