A comparison between the Felix von Luschan Skin Color Scale Test and Invasive Neonatal Jaundice Measurement Methods

Öz

Objective: This study aimed to compare invasive neonatal jaundice measurement methods (total bilirubin from venous blood, total bilirubin in blood gas, and microcapillary neonatal bilirubin from the heel) with the non-invasive Felix von Luschan skin color scale test.

Material and Methods: The study was performed on 110 newborns admitted to the neonatal intensive care unit of Adiyaman University Training and Research Hospital, Turkey, because of jaundice. The non-invasive Felix von Luschan skin color scale test was compared with other, more invasive neonatal jaundice measurement methods.

Results: The Felix von Luschan skin color scale test was found to have a significant relationship with other diagnostic methods (p<0.001) and deemed practical for the diagnosis of this disease.

Conclusion: The timely diagnosis and management of neonatal jaundice are essential to prevent acute bilirubin encephalopathy and kernicterus. The Felix von Luschan skin color scale test is a non-invasive method that is reliable, fast and inexpensive. This method can be used for the diagnosis of neonatal jaundice. 

Anahtar Kelimeler

• Felix von Luschan Skin Color Scale
• neonatal jaundice
• non-invasive
• Bilirubin

Yenidoğan Sarılık Ölçüm Yöntemleri ile Felix von Luschan Deri Rengi Skalasının Karşılaştırılması

Öz

Amaç: Bu çalışmanın amacı invaziv neonatal sarılık ölçüm yöntemleri (venöz kandan toplam bilirubin, kan gazındaki toplam bilirubin ve topuktan mikrokapiller neonatal bilirubin) ile invaziv olmayan Felix von Luschan Deri Rengi Skalasını karşılaştırmak.

Gereç ve Yöntemler: Bu çalışma, Adıyaman Üniversitesi Eğitim ve Araştırma Hastanesi, yenidoğan yoğun bakım ünitesine sarılık nedeniyle başvuran 110 yenidoğan üzerinde gerçekleştirildi. İnvaziv olmayan Felix von Luschan Deri Rengi Skalası diğer invaziv yenidoğan sarılık ölçüm yöntemleriyle karşılaştırıldı.

Bulgular: Felix von Luschan deri renk skalası testinin diğer tanı yöntemleri ile anlamlı bir ilişkisi olduğu (p <0.001) ve bu hastalık tanısında yararlı olduğu bulunmuştur.

Sonuç: Yenidoğan sarılıklarının zamanında teşhis ve tedavisi, akut bilirubin ensefalopatisini ve kernikterusu önlemek için gereklidir. Felix von Luschan ten rengi testi, güvenilir, hızlı ve ucuz bir yöntem olan, invaziv olmayan bir yöntemdir. Bu yöntem yenidoğan sarılığı tanısı için kullanılabilir.

Anahtar Kelimeler

• Felix von Luschan Deri Rengi Skalası
• yenidoğan sarılığı
• non-invaziv
• Bilirubin

Kaynakça

1. 1. Porter ML, Dennis BL. Hyperbilirubinemia in the term newborn. Am Fam Physician, 2002 Feb 15:65(4):599-606.
2. 2. Ercan Ş, Özgün G. The accuracy of transcutaneous bilirubinometer measurements to identify the hyperbilirubinemia in outpatient newborn population. Clin Biochem, 2018 May; 55:69-74.
3. 3. Fakhri M, Farhadi R, Mousavinasab N, et.al. Preventive effect of purgative manna on neonatal jaundice: a double blind randomized controlled clinical trial. J Ethnopharmacol, 2019 May 23; 236; 240-249.
4. 4. Tavakolizadeh R, Izadi A, Seirafi G, Khedmat L, Mojtahedi SY. Maternal risk factors for neonatal jaundice: a hospital-based cross-sectional study in Tehran. Eur J Transl Myol 2018 Jul 10;28(3):7618.
5. 5. Ullah S, Rahman K, Hedayati M. Hyperbilirubinemia in Neonates: Types, causes, clinical examinations, preventive measures and treatments: a narrative review article. Iran J Public Health 2016 May; 45(5); 558-568.
6. 6. Greco C, Iskander IF, El Houchi SZ, et.al; study team. Diagnostic performance analysis of the point-of-care bilistick system in identifying severe neonatal hyperbilirubinemia by a multi-country approach. E Clinical Medicine, 2018 Jul 17;1:14-20.
7. 7. Swiatoniowski AK, Quillen EE, Shriver MD, Jablonski NG. Technical note: comparing von Luschan skin color tiles and modern spectrophotometry for measuring human skin pigmentation. Am J Phys Anthropol, 2013 Jun; 151(2):325-330.
8. 8. Dark Tichondrias at English Wikipedia. Wikipedia.org. San Francisco: Wikipedia Foundation, Inc. https://en.wikipedia.org/wiki/File:Felix_von_Luschan_Skin_Color_Chart.JPG. Accessed 15 August 2019

9. 9. Mir SE, van der Geest BAM, Been JV. Management of neonatal jaundice in low and lower-middle-income countries. BMJ Paediatr Open, 2019 Feb 14;3(1):e000408.
10. 10. Abbey P, Kandasamy D, Naranje P. Neonatal Jaundice, Indian J Pediatr, 2019 Sep; 86(9):830-841.
11. 11. Shah MH, Ariff S, Ali SR, et.al. Quality improvement initiative using transcutaneous bilirubin nomogram to decrease serum bilirubin sampling in low-risk babies. BMJ Paediatr Open, 2019 Apr 24;3(1):e000403.
12. 12. Cordero C, Schieve LA, Croen LA, et.al. Neonatal jaundice in association with autism spectrum disorder and developmental disorder. J Perinatol, 2019 Aug 6; doi: 10.1038/s4172-019-0452-4.
13. 13. Cheng NY, Lin YL, Fang MC, Lu WH, Yang CC, Tseng SH. Noninvasive transcutaneous bilirubin assessment of neonates with hyperbilirubinemia using a photon diffusion theory-based method. Biomed Opt Express, 2019 May 23; 10(6):2969-2984.
14. 14. Arman D, Topcuoğlu S, Gürsoy T, Ovalı F, Karatekin G. The accuracy of transcutaneous bilirubinometry in preterm infants. J Perinatol 2019 Jul 30; doi:10.1038/s41372-019-0445-3.
15. 15. Kaur CD, Saraf S. Skin care assessment on the basis of skin hydration, melanin, erythema and sebum at various body sites. International Journal of Pharmacy and Pharmaceutical Sciences. 2011 Jan; 3: 209-213.
16. 16. Clarys P, Alewaeters K, Lambrecht R. Barel AO. Skin color measurements: comparison between three instruments: The Chromameter, the DermaSpectrometer and the Mexameter. Skin Res Technol, 2000 Nov, 6(4):230-238.
17. 17. Treesirichod A, Chansakulporn S, Wattanapan P. Correlation between skin color evaluation by skin color scale chart and narrawband reflectance spectrophotometer. Indian J Dermatol, 2014 Jul; 59(4):339-342.
18. 18. Mitra S, Rennie J. Neonatal jaundice: aetiology, diagnosis and treatment. Br J Hosp Med (Lond) 2017 Dec 2; 78(12):699-704.
19. 19. Allen D. Neonatal jaundice. Nurs Child Young People, 2016 Jul 8;28(6):11.
20. 20. Rana N, Ranneberg LJ, Målqvist M, Kc A, Andersson O. Delayed cord clamping was not associated with an increased risk of hyperbilirubinemia on the day of birth or jaundice in the first 4 weeks. Acta Paediatr, 2019 Jun 25; doi: 10.1111/apa.14913.
21. 21. Safar H, Elsary AY. Neonatal jaundice: the other side of the coin in the development of allergy. Am J Perinatol 2019 Jul 31; doi: 10.1055/s-00039-1693697.