Unexpected Hyperkalemia During Kawasaki Disease

Yıl 2024, ERKEN GÖRÜNÜMLÜ MAKALELER, 1 - 4

Gülsüm İclal Bayhan Muhammed Yasin Gökdöl Abdullah Talha Öcal Utku Pamuk Vildan Güngörer Tuğba Erat Aslınur Özkaya Parlakay

https://doi.org/10.12956/tchd.1393779

Öz

Pseudohyperkalemia is defined as a markedly elevated serum potassium level with a normal plasma potassium concentration. It is mainly caused by leucocytosis and thrombocytosis. Here we report an infant treated with aspirin for Kawasaki disease who developed hyperkalemia during follow-up. He was finally diagnosed with pseudohyperkalemia based on a normal whole blood potassium level measured with a blood gas analyser.

Anahtar Kelimeler

Kawasaki disease, hyperkalemia, NSAIDs, nonsteroidal anti-inflammatory drugs, pseudohyperkalemia

Kawasaki Hastalığının Seyri Sırasında Beklenmedik Şekilde Gelişen Hiperkalemi

Öz

Psödohiperkalemi, plazma potasyum konsantrasyonu normal iken serum potasyum seviyesinin belirgin şekilde yüksek bulunması olarak tanımlanır. Esas olarak lökositoz ve trombositozdan kaynaklanır. Burada, Kawasaki hastalığı için aspirin ile tedavisi alan ve takip sırasında hiperkalemisi gelişen bir bebek bildirilmektedir. Kan gazı cihazı ile ölçülen tam kan potasyum seviyesinin normal bulunması ile psödohiperkalemi tanısı konulmuştur.

Anahtar Kelimeler

Kawasaki hastalığı, hiperkalemi, NSAİİ, nonsteroid antiinflamatuvar ilaçlar, psödohiperkalemi

Kaynakça

• Lehnhardt A, Kemper MJ. Pathogenesis, diagnosis and management of hyperkalemia. Pediatr Nephrol 2011;26:377-84. 
• Meng QH, Wagar EA. Pseudohyperkalemia: A new twist on an old phenomenon. Crit Rev Clin Lab Sci 2015;52:45-55.
• Daly K, Farrington E. Hypokalemia and hyperkalemia in infants and children: pathophysiology and treatment. J Pediatr Health Care 2013;27:486-96.
• Rotenberg FA, Giannini VS. Hyperkalemia associated with ketorolac. Ann Pharmacother 1992;26:778-9.
• Tan SY, Shapiro R, Franco R, Stockard H, Mulrow PJ. Indomethacin-induced prostaglandin inhibition with hyperkalemia. A reversible cause of hyporeninemic hypoaldosteronism. Ann Intern Med 1979;90:783-5. 
• Janjua H. Management of hyperkalemia in children. Curr Opin Pediatr. 2023 Nov 27. doi: 10.1097/MOP.0000000000001321.
• Asirvatham JR, Moses V, Bjornson L. Errors in potassium measurement: a laboratory perspective for the clinician. N Am J Med Sci 2013;5:255-9
• Shimizu T, Yamashiro Y, Yabuta K. Pseudohyperkalaemia in Kawasaki disease. Eur J Pediatr 1992;151:497-8.
• Sevastos N, Theodossiades G, Archimandritis AJ. Pseudohyperkalemia in serum: a new insight into an old phenomenon. Clin Med Res 2008;6:30-2.
• Robson WL, Kabani AM, Leung AK, Fick GH, McKenna AI. The relationship of the serum potassium to the platelet count in children. Clin Pediatr (Phila) 1992 ;31:123-5.
• Graber M, Subramani K, Corish D, Schwab A. Thrombocytosis elevates serum potassium. Am J Kidney Dis 1988;12:116-20.
• Mäkelä K V Kairisto, O Peltola, T Hollmén, A Virtanen, K Pulkki, V Näntö. Effect of platelet count on serum and plasma potassium: evaluation using database information from two hospitals. Scand J Clin Lab Invest Suppl 1995;222:95-100
• Šálek T. Pseudohyperkalemia - Potassium released from cells due to clotting and centrifugation - a case report. Biochem Med (Zagreb) 2018;28:011002.