Frank sign ilk kez akut koroner sendromla başvuran hastalarda daha ileri koroner arter hastalığını öngörebilir

Öz

Amaç: Frank Sign olarak da adlandırılan diyagonal kulak memesi kırışıklığı (DELC), kulak memesinin derisinde çapraz kıvrım veya kırışık benzeri bir çizgidir. Fizik muayenede tespit edilen bu işaret, yüksek kardiyovasküler hastalık riski taşıyan bireyler için prognostik bir belirteç olarak önerilmiştir. Çalışmamızın amacı, ilk kez akut koroner sendrom (AKS) tanısı almış hastalarda DELC varlığı ile koroner arter hastalığı şiddeti arasındaki ilişkiyi SYNTAX skoruna göre değerlendirmektir. Gereç ve Yöntem: Kasım 2015-Aralık 2016 tarihleri arasında AKS tanısı ile acil servise başvuran 356 hasta çalışmaya alındı. Hastalar 3 gruba ayrıldı: düşük SYNTAX skoru (< 23), yüksek SYNTAX skoru (≥23) ve normal koroner hastaları. Bulgular: DELC'li hastalar yüzde olarak tüm gruplar arasında istatistiksel olarak anlamlı derecede farklıydı (p < 0,001). Daha yüksek DELC sayısı (OR = 0.497; %95 CI: 0.246-1.001; p = 0.043), çoklu lineer regresyon analizinden sonra AKS hastalarında yüksek SYNTAX skoru için bağımsız bir öngörücüydü. Sonuç: Frank Sign, birincil uygulayıcıların CAD'nin ciddiyetini tahmin etmelerine yardımcı olabilir.

Anahtar Kelimeler

• Akut koroner sendrom
• Diyagonal kulak memesi kırışıklığı
• Frank Sign
• SYNTAX skoru.

Frank sign may predict more advanced coronary artery disease in patients admitted with a first time acute coronary syndrome

Öz

Aim: Diagonal ear lobe crease (DELC), also called as Frank's sign, is a diagonal fold or wrinkle-like line in the skin of the earlobe. This sign detected on the physical examination was proposed as a surrogate marker for individuals at high risk of cardiovascular disease. The aim of our study was to assess the relationship between presence of DELC and the severity of coronary artery disease according to the SYNTAX score in patients with firstly diagnosed acute coronary syndrome (ACS). Material and Methods: 356 patients admitted to the emergency department with the diagnosis of ACS from November 2015 to December 2016 were enrolled into the study. Patients were stratified into 3 groups: low SYNTAX score (< 23), high SYNTAX score (≥23) and patients with normal coronary. Results: Patients with DELC as percentage were statistically significantly different between all groups (p < 0.001). Higher number of DELC (OR = 0.497; 95% CI: 0.246-1.001; p = 0.043) was an independent predictor for a high SYNTAX score in the ACS patients after multiple linear regression analysis. Conclusion: Frank’s sign can help primary practitioners to predict severity of CAD.

Anahtar Kelimeler

• Acute coronary syndrome
• Diagonal ear lobe crease
• Frank’s sign
• SYNTAX score.

Kaynakça

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