Tam Kan Sayımı Parametreleri ile İleri Evre Mide Kanseri Olan Hastaların Prognozunu Tahmin Edilebilir Mi?

Öz

Amaç: Metastatik mide kanseri sık görülen ve prognozu kötü olan bir hastalıktır. Bu yaygın hastalıkta prognozun basit bir tam kan sayımı ile tahmin edilmesi birçok çalışmada dikkatleri üzerine çekmiştir. Ancak çalışmaların sonuçları birbiriyle uyumlu değildir. Bu çalışmanın amacı, ilerlemiş mide kanserli (İMK) hastalarda tam kan sayımı parametreleri ile hastalık prognozu arasındaki ilişkiyi değerlendirmektir. Gereç ve Yöntemler: Hastaların İMK tanısı anında herhangi bir tedavi almadan önce kan sayımları incelendi. Tam kan sayımından elde edilen tüm parametreler kayıt edildi; Nötrofil lenfosit oranı (NLR), trombosit lenfosit oranı (PLR), monosit lenfosit oranı (MLR), sistemik immün-enflamasyon indeksi (SII). Hastalar medyan NLR, PLR, MLR ve SII değerlerine göre iki alt gruba ayrıldı. Bulgular: Çalışmaya İMK'li toplam 105 hasta dahil edildi. Düşük NLR grubundaki hastalarda medyan sağkalım 14,6 ay iken, yüksek NLR grubunda 7,9 aydı (p=0,008). Ortanca sağkalım düşük PLR grubunda 12.7 aya karşı yüksek PLR grubunda 8.2 aydı (p=0.019). Ortanca sağkalım süresi yüksek MLR grubunda 14.6 ay iken, düşük MLR grubunda 7.9 aydı (p=0.06). Sonuç: Tam kan sayımından elde edilen parametreler aracılığıyla NLR, İMK'li hastalarda umut verici bir prognostik belirteç gibi görünmektedir.

Anahtar Kelimeler

• mide kanseri
• inflamasyon
• nötrofil
• genel sağkalım
• nötrofil-lenfosit oranı
• tam kan sayımı

Parameters of Complete Blood Count Might Predict the Prognosis of Patients with Advanced Gastric Cancer

Öz

Metastatic gastric cancer is a common disease with poor prognosis. In this common disease, estimating the prognosis with a simple complete blood count has attracted the attention in many studies. However, the results of the studies are incompatible with each other. The aim of the study was to evaluate the relationship between parameters of the complete blood count and disease prognosis in patients with advanced gastric cancer(AGC). Blood counts of the patients were examined before receiving any treatment at the time of diagnosis of AGC. All parameters derived from complete blood count. These were; Neutrophil lymphocyte ratio(NLR), platelet lymphocyte ratio(PLR),monocyte lymphocyte ratio(MLR), systemic immune-inflammation index(SII). The patients were divided in two subgroups according to the median values of NLR, PLR, MLR and SII. A total of 105 patients with AGC were included in the study. The median survival in the patients with low NLR group was 14.6 months compared with high NLR group was 7.9 months(p=0.008). In low PLR and MLR group the median survivals were 12.7 and 14.6 months compared with high PLR and MLR were 8.2 and 7.9 months respectively(p=0.019,p=0.06). Through the parameters derived from complete blood count, NLR appears to be a promising prognostic marker in patients with AGC.

Anahtar Kelimeler

• gastric cancer
• neutrophil
• overall survival
• prognosis

Kaynakça

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