Tek taraflı pseudoeksfolyasyon materyali olan glokomlu ve hastalıksız bireylerin, optik koherens tomografi-anjiografi cihazı ile makula değerlendirmesi

Yıl 2023, , 482 - 489, 30.09.2023

Cansu Yüksel Elgin

https://doi.org/10.18663/tjcl.1308157

Öz

Amaç: Tek taraflı pseudoekfolyasyon materyali (XFM) izlenen bireylerin; glokom geliştiği ve gelişmediği durumlarda makula vasküler yoğunluğunun gözler arası değişimini gözlemlemek.
Gereç ve yöntemler: 38 sayıda tek taraflı pseudoeksfolyasyon sendromlu (XFS) bireyin 76 gözü ve 36 sayıda tek taraflı pseudoeksfolyasyon glokomlu (XFG) hastanın 72 gözü çalışmaya dahil edilmiştir. Her iki grubun XFM olan ve olmayan gözlerinin OCT-A ile incelenen tüm makuler belirteçleri standart ortalama karşılaştırmalı t testi ile değerlendirilmiştir. Her iki gruptaki XFM pozitif ve negatif olan göz grupları birbirleriyle ve gruplar arasında Kruskal-Wallis testi ile kıyaslanmıştır.
Bulgular : Tek taraflı XFS olan hastaların gözler arası yüzeyel kapiller pleksus yoğunluğunda anlamlı farklılıklar minimal görülürken tek taraflı XFG’lerin gözler arası makulanın totalinde (p= 0,0004) üst ve alt yarımında (p=0.0018, p=0.0002), fovea (p=0,014), parafovea (p=0,0411) ,parafoveanın inferior yarımı (p=0,0126) ve temporalinde (p=0,0126); glokomlu gözlerde anlamlı düzeyde damar yoğunluğunda azalma dikkati çekmektedir. Derin kapiller pleksusta ise hem grup içi hem gruplar arası kıyaslamalarda anlamlılık, yüzeyel damar tabakasına göre azalmıştır.
Sonuç: Medikal tedaviyle kontrol edilen glokom tablolarında makula bölgesindeki özellikle yüzeyel kapiller pleksusun yoğunluğunda azalma olduğu gösterilmiştir. Ancak bu damarsal azalma glokomsuz gözlerde XFM varlığında öncü bulgu olarak gösterilememiştir.

Anahtar Kelimeler

Optik koherens tomografi-anjiyografi, makula damar yoğunluğu, psödoeksfoliasyon glokomu

Evaluation of macula with optical coherence tomography-angiography device in glaucomatous and disease-free individuals with unilateral pseudoexfoliation material.

Öz

Aim: The aim of this study was to observe interocular variations in macular vascular density among individuals with unilateral pseudoexfoliation material (XFM) and its association with glaucoma development.
Material and Methods: The study included a total of 76 eyes from 38 individuals with unilateral pseudoexfoliation syndrome (XFS) and 72 eyes from 36 individuals with unilateral pseudoexfoliation glaucoma (XFG). OCT-A was used to examine all macular markers in both XFM-positive and XFM-negative eyes within each group, and the data were analyzed using the standard mean comparison t-test. Furthermore, the Kruskal-Wallis test was used to compare the XFM-positive and XFM-negative eye groups between the XFS and XFG cohorts. Results: The unilateral XFS group showed relatively infrequent significant differences in superficial capillary plexus density between the eyes. In contrast, the unilateral XFG group exhibited a significant decrease in vascular density in various macular regions, including the total macula (p=0,0004), superior and inferior hemifields (p=0,0018, p=0,0002), fovea (p=0,014), parafovea (p=0,0411), inferior half of parafovea (p=0,0126), and temporal region (p=0,0126). However, the deep capillary plexus showed decreased significance in both within-group and between-group comparisons compared to the superficial vascular layer. Conclusion: Our findings indicate a decrease in macular capillary plexus density, particularly in the superficial region, in glaucoma cases effectively managed with medical treatment. However, this vascular decrease could not be identified as an early sign in the presence of XFM (pseudoexfoliation material), which is a significant risk factor for glaucoma.

Anahtar Kelimeler

optic coherens tomography-angiography, macula vessel density, pseudoexfoliation glaucoma

Kaynakça

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