Morbid obezite hastalarında laparoskopik sleeve gastrektomi öncesi ve sonrası Tp-e aralığı ve Tp-e/QT oranının değerlendirilmesi

Yıl 2023, , 571 - 575, 30.09.2023

Altan Aydın

https://doi.org/10.18663/tjcl.1343971

Öz

Amaç: Tp-e/QT oranı, ventriküler repolarizasyonun yeni bir belirtecidir. Obezite, çeşitli kardiyovasküler değişiklikler ve artan kardiyovasküler hastalık riski ile ilişkilendirilmiştir. Obezite, ventriküler aritmi riskini potansiyel olarak artırabilen QT aralığının uzaması ile ilişkili olabilir. Morbid obezitesi olan hastalarda laparoskopik tüp mide operasyonu (LSG) öncesi ve sonrası Tp-e aralığı ve Tp-e/QT oranının değerlendirilmesini araştırmayı amaçladık.
Gereç ve yöntemler: Bu çalışmada, Ocak 2012 ile Aralık 2016 tarihleri arasında BMI >40 kg/m2 veya komorbiditeleri ve BMI >35kg/m2 olan ve daha önce konservatif yöntemlerle kilo vermeyi başaramayan 93 hastaya ardışık olarak LSG uygulandı.
Bulgular: Kalp hızı (75,7 ± 4,7 vs 72,8 ± 11,4; p=0,486), QT aralığı (358,1 ± 32,0 vs 362,6 ± 30,4; p=0,399) ve QTc aralığı (399,0 ± 34,3 vs 396,2 ± 30,9; p=0,621) LSG öncesi ve sonrası benzerdi. Tp-e aralığı (81,3 ± 11,4 vs 76,3 ± 10,9; p=0,004), Tp-e/QT oranı (0,23 ± 0,04 vs 0,21 ± 0,04; p=0,002), Tp-e/QTc oranı (0,20 ± 0,03) vs. 0,19 ± 0,03; p=0,001) LSG öncesi ve sonrasında anlamlı olarak farklıydı.
Sonuç: Çalışmamız morbid obezitenin ventriküler repolarizasyon üzerinde olumsuz etkisi olabileceğini göstermiştir. Obez hastalarda laparoskopik sleeve gastrektomiyi takiben önemli kilo kaybına, ventriküler repolarizasyonda önemli bir iyileşme eşlik eder.

Anahtar Kelimeler

Laparoskopik sleeve gastrektomi; morbid obezite, QT aralığı, Tp-e aralığı, Tp-e/QT oranı, ventriküler repolarizasyon.

Teşekkür

Thanks to Dr.Çağrı Yayla for his support and contributions.

The assessment of Tp-e interval and Tp-e/QT ratio in patients with morbid obesity before and after laparoscopic sleeve gastrectomy

Öz

Aim: Tp-e/QT ratio is a novel marker of ventricular repolarisation. Obesity has been associated with various cardiovascular changes and an increased risk of cardiovascular disease. Obesity may be associated with prolongation of the QT interval, which could potentially increase the risk of ventricular arrhythmias. We aimed to research the assessment of Tp-e interval and Tp-e/QT ratio before and after laparoscopic sleeve gastrectomy (LSG) in patients with morbid obesity.
Material and Methods: In this study, we enrolled 93 consecutive patients with a BMI >40 kg/m2 or BMI >35kg/m2 with comorbidities who had previously failed to lose weight with conservative methods underwent LSG between January 2012 and December 2016.
Results: Heart rate (75.7 ± 4.7 vs. 72.8 ± 11.4; p=0.486), QT interval (358.1 ± 32.0 vs. 362.6 ± 30.4; p=0.399) and QTc interval (399.0 ± 34.3 vs. 396.2 ± 30.9; p=0.621) were similar before and after LSG. Tp-e interval (81.3 ± 11.4 vs. 76.3 ± 10.9; p=0.004), Tp-e/QT ratio (0.23 ± 0.04 vs. 0.21 ± 0.04; p=0.002), Tp-e/QTc ratio (0.20 ± 0.03 vs. 0.19 ± 0.03; p=0.001) were significantly different before and after LSG.
Conclusion: Our study showed that morbid obesity may have a negative effect on ventricular repolarization. Substantial weight loss following laparoscopic sleeve gastrectomy in obese patients is accompanied by a significant improvement in ventricular repolarization.

Anahtar Kelimeler

Laparoscopic sleeve gastrectomy, morbid obesity, QT interval, Tp-e interval, Tp-e/QT ratio, ventricular repolarization.

Kaynakça

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