Ropivakain, levobupivakain ve bupivakainin farklı sıcaklıklardaki antimikrobiyal etkileri

Öz

Amaç: Lokal anestezik (LA) ilaçların, daha önce yapılan çeşitli çalışmalarla olası bir antimikrobiyal aktivitesi gösterilmiştir. Bu çalışmanın amacı, rejyonel anestezi uygulamalarında yaygın olarak kullanılan ropivakain, levobupivakain ve bupivakain gibi ticari olarak mevcut LA ilaçlarının farklı sıcaklıklarda S.aureus ATCC 6538, S. epidermidis, E.coli ve Candida albicans üzerindeki antimikrobiyal (antibakteriyel veya antifungal) aktivitesini değerlendirmektir. Gereç ve Yöntemler: Mikrobiyoloji laboratuvarında ropivakain (%1 ve %0,125), levobupivakain (%0,75 ve %0,125) ve bupivakainin (%0,5 ve %0,125) hastalardan izole edilen S.aureus ATCC 6538, S.epidermidis, E.coli ve C.albicans ATCC 10231 üzerindeki olası antimikrobiyal etkileri 240C ve 370C’de araştırıldı. Bulgular: Her üç lokal anestezik ilaç da, 37°C ve 24°C'de 3. ve 12. saatlerde antifungal aktivite göstermiştir. Levobupivakainin (%0,75) antibakteriyel etkisi 12. saatte gözlendi. Ropivakain (%1) 37°C'de 3. ve 12. saatlerde 24°C'ye göre nispeten daha fazla antibakteriyel etkiye sahipken, bupivakain daha az antibakteriyel etkiye sahipti. Sonuçlar: Lokal anesteziklerin antibakteriyel veya antifungal etkilerinin potansiyel klinik sonuçları umut verici olabilir.

Anahtar Kelimeler

• Lokal anestezikler
• bupivakain
• levobupivakain
• ropivakain
• Antimikrobiyal aktivite
• antibakteriyel
• antifungal

Antimicrobial effects of ropivacaine, levobupivacaine and bupivacaine at different temperatures

Öz

Aim: Various prior studies have shown a possible antimicrobial activity of different local anesthetic (LA) drugs. The aim of this study was to assess the antimicrobial (antibacterial or antifungal) activity of commonly used commercially available LA drugs used in regional anesthesia practice such as; ropivacaine, levobupivacaine and bupivacaine on S.aureus ATCC 6538, S. epidermidis, E.coli and Candida albicans at different temperatures. Material and Methods: Possible antimicrobial effects of ropivacaine (1% and 0.125%), levobupivacaine (0.75% and 0.125%) and bupivacaine (0.5% and 0.125%) on S.aureus ATCC 6538, S.epidermidis, E.coli and C.albicans ATCC 10231, which were isolated from patients in the microbiology laboratory were investigated at 240C and 37C. Results: All three LA drugs showed antifungal activity at 37°C and 24°C in 3rd and 12th hours. Levobupivacaine’s (0.75%) antibacterial effect was observed at the 12th hour. Ropivacaine (1%) had relatively more antibacterial effect at the 3rd and 12th hour at 37°C rather than 24°C whereas bupivacaine had less. Conclusion: Potential clinical implications of antibacterial or antifungal effects of local anesthetics might be promising.

Anahtar Kelimeler

• Local anesthetics
• bupivacaine
• levobupivacaine
• ropivacaine
• Antimicrobial activity
• antibacterial
• antifungal

Kaynakça

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