Asemptomatik hiperüriseminin hidradenitis süppürativa hastalık seyrine etkileri

Öz

Amaç: Hidradenitis süppürativa (HS) hastaların hayat kalitesini belirgin olarak etkileyen ağrılı abse ve nodüller, sinus traktüsleri ve skarlarla karakterize kronik inflamatuar bir hastalıktır. Hastalığa metabolik sendrom, kardiyovasküler hastalıklar ve artrit gibi komorbiditeler eşlik etmektedir. Asemptomatik hiperüriseminin sıklığı günümüzde giderek artmaktadır ve inflamasyonu şiddetlendirdiğine dair veriler mevcuttur. Bu çalışmada hiperüriseminin HS hastalarında hastalık şiddeti, klinik ve laboratuvar bulgularıyla ilişkisini incelemeyi amaçladık. Gereç ve Yöntemler: Bu kesitsel çalışmaya Pamukkale Üniversitesi dermatoloji kliniğinde HS tanısı alan hastaların yanı sıra beden kitle indeksi (BKİ), yaş, cinsiyet açısından benzer nitelikte olan, inflamatuar dermatolojik hastalığı olmayan gönüllüler dahil edildi. Serum ürik asit (SÜA), C-reaktif protein (CRP), açlık glukoz, yüksek yoğunluklu lipoprotein kolesterol (HDL), total kolesterol ve trigliserid değerleri kaydedildi. Hastalık şiddetinin belirlenmesi için Hurley sınıflaması ve Uluslararası Hidradenitis Suppurativa Şiddet Skorlaması (IHS4) kullanıldı. Tüm hastalara dermatoloji yaşam kalite indeksi (DYKİ) uygulanarak hastalığın hayat kaliteleri üzerine etkisi incelendi. Bulgular: Çalışmaya 53 HS tanılı hasta, 44 gönüllü dahil edildi. HS hastalarının 23’ünde (%43.4) hiperürisemi mevcuttu. Hastaların ortalama SÜA seviyeleri, kontrol grubundan yüksek olarak saptandı (6.4±1.4 mg/dL, 4.8±1.4 mg/dL, sırasıyla p<0.001). Hiperürisemisi olan hastalarda IHS4 skoru hiperürisemisi olmayan hastalardan belirgin olarak yüksekti (14.8± 12.5 ve 8.5 ±5.6, sırasıyla, p<0.05). CRP düzeyleri benzer şekilde hiperürisemisi olan hastalarda daha yüksekti, ancak aralarındaki farklılık istatistiksel açısından anlamlı değildi (p>0.05). Hasta grubunda serum CRP düzeyleri ile SÜA seviyeleri arasında pozitif korelasyon vardı (r=0.342, p=0.012). Sonuçlar: HS hastalarında asemptomatik hiperürisemi sıklığı artmıştır ve hastalık şiddetiyle ilişkili bulunmuştur. Hiperürisemi, HS ve ilişkili komorbiditeler arasında yakın ilişki bulunmaktadır ve hasta takibinde SÜA düzeyi rutin inceleme arasına alınmalıdır.

Anahtar Kelimeler

• hidradenitis süppürativa
• ürik asit
• asemptomatik hiperürisemi

Effects of asymptomatic hyperuricemia on the disease course of hidradenitis suppurativa

Öz

Aim: Hidradenitis suppurativa (HS) is a chronic inflammatory disease characterized by painful abscesses and nodules, sinus tracts, and scars significantly affecting patients' quality of life. HS is accompanied by comorbidities such as metabolic syndrome, cardiovascular diseases, and arthritis. The frequency of asymptomatic hyperuricemia is increasing nowadays, and it is widely known that it exacerbates inflammation. In this study we aimed to investigate the possible association of hyperuricemia with disease severity, clinical and laboratory findings in HS patients. Material and Methods: Patients diagnosed with HS at Pamukkale University Dermatology Department were included in this cross-sectional study. Individuals with similar body mass index (BMI), age, and gender, and without inflammatory dermatoses were included in the control group. Serum uric acid (SUA), C-reactive protein (CRP), fasting blood glucose, high-density lipoprotein cholesterol (HDL), total cholesterol, and triglyceride levels were assessed. Hurley classification and International Hidradenitis Suppurativa Severity Score (IHS4) were used to determine disease severity. Dermatology Life Quality Index (DLQI) was used to assess the effect of the disease on their quality of life. Conclusion: 53 patients with HS and 44 controls were included in the study. Hyperuricemia was present in 23 (43.4%) of HS patients. SUA levels of the patients were higher than the control group (6.4±1.4 mg/dL and 4.8±1.4 mg/dL, respectively, p<0.001). The IHS4 score was significantly higher in patients with hyperuricemia than in patients without hyperuricemia. (14.8±12.5 and 8.5±5.6, respectively, p<0.05). Serum C-reactive protein (CRP) levels were also higher in patients with hyperuricemia, but the difference was not statistically significant (p>0.05). There was a positive correlation between serum CRP levels and SUA levels in the patient group. Results: The frequency of asymptomatic hyperuricemia is increased in HS patients and is associated with disease severity. There is a close relationship between Hyperuricemia and HS and associated comorbidities, and patients should be evaluated.

Anahtar Kelimeler

• Hidradenitis suppurativa
• uric acid
• asymptomatic hyperuricemia

Kaynakça

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