Araştırma Makalesi

Assessing the efficacy of 5% dextrose prolotherapy in patients with partial anterior cruciate ligament tears

Cilt: 16 Sayı: 3 30 Eylül 2025
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Assessing the efficacy of 5% dextrose prolotherapy in patients with partial anterior cruciate ligament tears

Öz

Aim: Prolotherapy is a regenerative injection treatment aimed at promoting the healing of musculoskeletal injuries. This study aimed to evaluate the effectiveness of 5% dextrose prolotherapy on pain levels and functional capacity in patients with partial anterior cruciate ligament (ACL) injuries. Materials and Methods: This retrospective study reviewed medical records of 60 patients with partial ACL tears who were matched 1:1 based on age and sex into two groups: a prolotherapy group (n = 30), who had received monthly injections of 5% dextrose solution for six sessions, and a control group (n=30), who had undergone physical therapy alone. Pain intensity was retrospectively assessed using the Visual Analog Scale (VAS), and functional outcomes were evaluated using the Lower Extremity Functional Scale (LEFS) from baseline records and after the 3rd and 6th treatment sessions. Results: Baseline demographic and clinical characteristics were similar between the two groups. By the third session, the prolotherapy group showed significantly reduced pain compared to the control group (VAS: 5.2 ± 1.1 vs. 7.9 ± 0.9, p < 0.001). By the sixth session, further significant pain reduction was observed in the prolotherapy group compared to controls (VAS: 2.8 ± 1.2 vs. 7.3 ± 1.0, p < 0.001). Functional capacity significantly improved in the prolotherapy group by the sixth session compared to the control group (LEFS: 68.6 ± 8.5 vs. 52.4 ± 7.3, p < 0.001). Conclusion: Administration 5% dextrose prolotherapy significantly reduced pain and improved functional capacity in patients with ACL tears. Prolotherapy may serve as an effective minimally invasive treatment option for ligamentous injuries of the knee.

Anahtar Kelimeler

Etik Beyan

Çalışma Helsinki Bildirgesi’ne uygun olarak yürütüldü ve Sağlık Bilimleri Üniversitesi, SBÜ Gülhane Eğitim ve Araştırma Hastanesi GETAT Klinik Araştırmalar Etik Kurulu’ndan onay alındı ​​(Tarih: 05.02.2025, Karar No: 2025/2).

Kaynakça

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  5. Wheaton MT, Jensen N. The Ligament Injury-Osteoarthritis Connection: The Role of Prolotherapy in Ligament Repair. J Prolother 2011; 3: 790-812.
  6. Torgutalp ŞŞ, Dönmez G, Korkusuz F. Incidence rates of injuries associated with anterior cruciate ligament tear diagnosed by magnetic resonance imaging: A retrospective cohort study. Spor Hekimliği Dergisi 2021; 56: 033-37.
  7. Hauser RA, Lackner JB, Steilen-Matias D, Harris DK. A Systematic Review of Dextrose Prolotherapy for Chronic Musculoskeletal Pain. Clin Med Insights Arthritis Musculoskelet Disord 2016; 9: 139-59.
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Ayrıntılar

Birincil Dil

İngilizce

Konular

Ağrı

Bölüm

Araştırma Makalesi

Yayımlanma Tarihi

30 Eylül 2025

Gönderilme Tarihi

31 Mayıs 2025

Kabul Tarihi

21 Temmuz 2025

Yayımlandığı Sayı

Yıl 2025 Cilt: 16 Sayı: 3

Kaynak Göster

APA
Solmaz, İ. (2025). Assessing the efficacy of 5% dextrose prolotherapy in patients with partial anterior cruciate ligament tears. Turkish Journal of Clinics and Laboratory, 16(3), 432-438. https://doi.org/10.18663/tjcl.1710550
AMA
1.Solmaz İ. Assessing the efficacy of 5% dextrose prolotherapy in patients with partial anterior cruciate ligament tears. TJCL. 2025;16(3):432-438. doi:10.18663/tjcl.1710550
Chicago
Solmaz, İlker. 2025. “Assessing the efficacy of 5% dextrose prolotherapy in patients with partial anterior cruciate ligament tears”. Turkish Journal of Clinics and Laboratory 16 (3): 432-38. https://doi.org/10.18663/tjcl.1710550.
EndNote
Solmaz İ (01 Eylül 2025) Assessing the efficacy of 5% dextrose prolotherapy in patients with partial anterior cruciate ligament tears. Turkish Journal of Clinics and Laboratory 16 3 432–438.
IEEE
[1]İ. Solmaz, “Assessing the efficacy of 5% dextrose prolotherapy in patients with partial anterior cruciate ligament tears”, TJCL, c. 16, sy 3, ss. 432–438, Eyl. 2025, doi: 10.18663/tjcl.1710550.
ISNAD
Solmaz, İlker. “Assessing the efficacy of 5% dextrose prolotherapy in patients with partial anterior cruciate ligament tears”. Turkish Journal of Clinics and Laboratory 16/3 (01 Eylül 2025): 432-438. https://doi.org/10.18663/tjcl.1710550.
JAMA
1.Solmaz İ. Assessing the efficacy of 5% dextrose prolotherapy in patients with partial anterior cruciate ligament tears. TJCL. 2025;16:432–438.
MLA
Solmaz, İlker. “Assessing the efficacy of 5% dextrose prolotherapy in patients with partial anterior cruciate ligament tears”. Turkish Journal of Clinics and Laboratory, c. 16, sy 3, Eylül 2025, ss. 432-8, doi:10.18663/tjcl.1710550.
Vancouver
1.İlker Solmaz. Assessing the efficacy of 5% dextrose prolotherapy in patients with partial anterior cruciate ligament tears. TJCL. 01 Eylül 2025;16(3):432-8. doi:10.18663/tjcl.1710550

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