Clinical profile and treatment outcomes of patients with urinary tract ınfections caused by raoultella planticola

Öz

Aim: This study aimed to evaluate the clinical characteristics, treatment approaches, and outcomes in patients diagnosed with urinary tract infections (UTIs) caused by Raoultella planticola. Material and Methods: This retrospective study included 25 adult patients with culture-confirmed Raoultella planticola UTIs admitted between January 2010 to January 2021. Clinical data such as demographics, presenting symptoms, comorbidities, laboratory findings, antibiotic treatments, and patient outcomes were retrospectively analyzed. Results: The mean patient age was 67.8 ± 16.8 years. The most frequent comorbidities included diabetes mellitus (28%), chronic heart failure (24%) and chronic renal failure (24%). Anemia (64%), bacteriuria (60%), arthritis (56%), and altered sensorium (52%) were the most common clinical presentations. Bacteremia was identified in all patients. Acute cystitis was diagnosed in 80% of cases, while sepsis was identified in 20%. Ceftriaxone (32%) and ciprofloxacin (24%) were the most frequently administered antibiotics. The median hospital stay was 5 days (IQR: 3-14). Two patients died during hospitalization (8% mortality); both had bacteremia without sepsis criteria, and one had underlying pancreatic cancer. Conclusion: Raoultella planticola UTIs predominantly affect older adults with significant comorbidities. While generally responsive to standard antimicrobial therapy, mortality may occur, particularly in patients with bacteremia and severe underlying diseases.

Anahtar Kelimeler

• Raoultella planticola
• urinary tract infections
• bacteremia
• antibiotic therapy
• clinical outcomes
• mortality

Etik Beyan

study was performed in accordance with the Declaration of Helsinki, and was approved by the Maltepe University Clinical Research Ethics Committee (Date: 02.05.2023, Approval No: 2023/900/26).

Raoultella planticola kaynaklı idrar yolu enfeksiyonu olan hastaların klinik profili ve tedavi sonuçları

Öz

Amaç: Bu çalışmanın amacı, Raoultella planticola kaynaklı idrar yolu enfeksiyonu (İYE) tanısı alan hastaların klinik özelliklerini, uygulanan tedavi yöntemlerini ve tedavi sonuçlarını değerlendirmektir. Gereç ve Yöntemler: Ocak 2010 ile Ocak 2021 tarihleri arasında, kültür ile doğrulanmış Raoultella planticola kaynaklı İYE tanısı ile yatırılan 25 erişkin hasta retrospektif olarak incelendi. Hastalara ait demografik veriler, başvuru semptomları, eşlik eden hastalıklar, laboratuvar bulguları, uygulanan antibiyotik tedavileri ve klinik sonuçlar değerlendirildi. Bulgular: Hastaların ortalama yaşı 67,8 ± 16,8 yıldı. En sık görülen eşlik eden hastalıklar diyabetes mellitus (%28), kronik kalp yetmezliği (%24) ve kronik böbrek yetmezliği (%24) idi. Başvuruda en sık gözlenen klinik bulgular anemi (%64), bakteriüri (%60), artrit (%56) ve bilinç değişikliği (%52) idi. Tüm hastalarda bakteremi tespit edildi. Hastaların %80’inde akut sistit tanısı konurken, %20’sinde sepsis saptandı. En sık uygulanan antibiyotikler seftriakson (%32) ve siprofloksasin (%24) idi. Medyan hastanede kalış süresi 5 gün olarak bulundu (IQR: 3-14). Hastane yatışı sırasında iki hasta (%8) hayatını kaybetti; her iki hastada da bakteremi mevcuttu ancak sepsis kriterlerini karşılamıyorlardı ve bir hastada altta yatan pankreas kanseri vardı. Sonuç: Raoultella planticola kaynaklı idrar yolu enfeksiyonları çoğunlukla ileri yaşta ve ek hastalığı olan bireyleri etkilemektedir. Bu enfeksiyonlar genellikle standart antibiyotik tedavisine iyi yanıt verse de, özellikle bakteremi ve ağır komorbiditeleri olan hastalarda mortalite görülebilmektedir.

Anahtar Kelimeler

• Raoultella planticola
• idrar yolu enfeksiyonları
• bakteremi
• antibiyotik tedavisi
• klinik sonuçlar
• mortalite

Kaynakça

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