Increased uric acid levels and clinical relationship in Polycystic Ovary Syndrome

Öz

Aim: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder that affects women of reproductive age. Clinical and biochemical characteristics are similar to metabolic syndrome. Insulin resistance in patients with metabolic syndrome is associated with serum uric acid levels. In our study, we aimed to investigate the relationship between serum uric acid levels and clinical and laboratory in PCOS patients.

Material and Method: 172 PCOS patients and, 34 years old, body mass index (BMI) matching control group of a total 206 cases attended to endocrinology outpatient clinic were included in the study. At early follicular phase, blood samples were taken after a 12-hour fasting period. Basal serum hormone levels were measured by immunoassay.

Results: Uric acid levels was significantly higher in PCOS than control group (4.25 ± 1.07 PCOS, 3.7 ± 0.79 control, P = 0,048). Uric acid levels were positively correlated with BMI, total cholesterol, insulin, cycle time, Feriman Gallwey score and negatively correlated with HDL cholesterol levels. Uric acid levels were 2 times higher than in PCOS group independent to age and BMI with multivariate logistic regression.

Conclusion: Uric acid levels in study group was significantly higher independent to age and BMI. Cardiovascular risk factors; LDL, insulin, triglycerides, BMI was positively correlated with uric acid in PCOS group. Clinical indicators; Feriman Gallwey score and cycle time was also positively correlated. Elevated uric acid levels in PCOS patients may be an independent risk factor for cardiovascular disease, may show negative results in the clinic.

Key words: cardiovascular disease, polycystic ovary syndrome, uric acid,

Polikistik Over Sendromlu hastalarda artmış ürik asit düzeyleri ve klinik ile ilişkisi

Öz

Amaç: Polikistikover sendromu (PKOS) üreme çağındaki kadınları etkileyen en sık endokrin bozukluktur. Klinik ve biyokimyasal özellikleri metabolik sendrom ile benzerlik göstermektedir. Metabolik sendromlu hastalarda insülin direnci, serum ürik asit düzeyi ile ilişkilidir. Çalışmamızda PKOS hastalarında serum ürik asit düzeylerinin laboratuar ve klinik ile ilişkisini incelemeyi amaçladık.

Gereç ve Yöntemler: Hastanemiz Endokrin Kliniğinde takip edilen 172 PKOS hastası, 34 yaş ve vücut kitle indeksi (VKİ) uyumlu kontrol grubu toplam 206 olgu katılmıştır. Erken folliküler fazda, 12 saat açlık sonrası kan örnekleri alınmıştır. Bazal serum hormon düzeyleri immunoassay ile değerlendirildi.

Bulgular: Ürik asid düzeylerinin PKOS grubunda kontrol grubuna göre istatistiksel olarak anlamlı bir şekilde daha yüksek saptanmıştır (4,25 ± 1,07 PKOS, 3,7 ± 0,79 kontrol, P = 0,048). Ürik asit ile VKİ, total kolesterol, insülin, siklus süresi, Ferriman Gallwey skoru arasında pozitif anlamlı korelasyon, HDL kolesterol ile anlamlı negatif korelasyon bulunmuştur. Çok değişkenli logistik regresyon yapıldığında ürik asit düzeylerinin PKOS grubunda yaş ve VKİ’den bağımsız olarak iki kat daha yüksek olduğu saptanmıştır.

Sonuçlar: Çalışmamızda PKOS grubunda ürik asit düzeyleri anlamlı bir şekilde yüksek bulunmuş ve bu yüksekliğin yaş ve VKİ’den bağımsız olduğu görülmüştür. Ürik asit ile kardiyovasküler risk faktörü olan kolesterol, Trigliserit, VKİ, insülin arasında pozitif korelasyon görülmüştür. Klinik gösterge olan Ferriman Gallwey, siklus süresi açısından da pozitif korelasyon saptanmıştır. Artmış ürik asit düzeyleri PKOS hastalarında kardiyovasküler hastalık oluşumu için bağımsız bir risk faktörü olabilir, klinikte olumsuz sonuçları gösterebilir.

Anahtar Kelimeler: Kardiyovasküler, polikistik over sendromu, ürik asit

Anahtar Kelimeler

• Kardiyovasküler, polikistik over sendromu, ürik asit

Kaynakça

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