Periodontal hastalıkta ileri oksidasyon protein ürünleri ve monosit kemoatraktan protein-1

Yıl 2018, , 1 - 6, 01.12.2018

Meltem Hendek , Ebru Olgun Erdemir , Üçler Kısa

https://doi.org/10.18663/tjcl.328204

Öz

Amaç: Çalışmanın
amacı periodontal hastalıklı ve sağlıklı bireylerde dişeti oluğu sıvısı (DOS) ileri oksidasyon protein
ürünleri (AOPP) ve monosit kemoatraktan protein-1 (MCP)-1seviyelerini
belirlemekti.

Gereç ve Yöntem: 25 kronik periodontitisli (KP), 25 gingivitisli (G) ve 25 periodontal
sağlıklı (S) toplam da 75 sigara içmeyen birey çalışmaya dahil edildi.
Sondalanabilir cep derinliği (SCD), klinik ataşman seviyesi (KAS), plak indeksi
(Pİ) ve gingival indeks (Gİ) kaydedildi. Her bireyde 4 alandan DOS örnekleri
toplandı ve DOS AOPP ve MCP-1 seviyeleri enzim bağlı immunosorbent analizi ile belirlendi.  

Bulgular: DOS
AOPP ve MCP-1 seviyeleri en düşük S grupta; ardından G grubunda ve en yüksek KP
grubunda idi. Bu farklılıklar G ve S grupları ile KP ve diğer gruplar arasında
istatistiksel olarak anlamlı farklıydı (p <.05). DOS AOPP ve MCP-1
seviyeleri arasında pozitif istatistiksel korelasyon bulundu.

Sonuç: Periodontal inflamasyon sırasında DOS
AOPP ve MCP-1 seviyeleri önemli bir rol oynayabilir ve artmış DOS AOPP ve MCP-1
seviyeleri, periodontal hastalıklar için potansiyel bir biyolojik belirteç
olarak önerilebilir.

Anahtar Kelimeler

İleri oksidasyon protein ürünleri, dişeti oluğu sıvısı, monosit kemoatraktan protein, oksidatif stres, periodontitis

Advanced oxidation protein products and monocyte chemoattractant protein-1 in periodontal disease

Öz

Aim:
The aim of the study was to determine gingival crevicular fluid (GCF) levels of
advanced
oxidation protein product (AOPP) and monocyte chemoattractant protein (MCP)-1
in subjects with periodontal disease and health.

Material and Method:
A total of 75 non-smokers, including 25 participants
with chronic periodontitis (CP), 25 participants
with gingivitis (G) and 25 participants with periodontally
healthy (H) were included into the present study.
The probing depth (PD), clinical attachment level (CAL), plaque index
(PI) and gingival index (GI) were recorded. The GCF samples from
4 sites in each individual were
collected and GCF AOPP and MCP-1 levels were determined
by enzyme-linked immunosorbent assay method.

Results:
GCF
AOPP and MCP-1 levels were the lowest
in the H group; followed by the G group and the highest in the CP group. These
differences were statistically significant between G and H groups
and between the CP and the other groups (p <.05). A statistically positive correlation was detected
between GCF AOPP and MCP-1 levels.

Conclusion: GCF
AOPP and
MCP-1 levels might
play a considerable role during periodontal inflammation and an elevated GCF AOPP and MCP-1
levels are suggested as a potential biomarker for
periodontal diseases.

Anahtar Kelimeler

Advanced oxidation protein products, gingival crevicular fluid, monocyte chemoattractant protein, oxidative stress, periodontitis

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