Bruselloz hastalarında serum YKL-40 düzeylerinin belirlenmesi

Öz

Amaç: Bruselloz tanılı hastalarda serum YKL-40 düzeylerini belirlemek.

Gereç ve Yöntemler: Bu çalışmaya serum aglütinasyon testi pozitif 40 Bruselloz hastası ve 41 sağlıklı kontrol grubu dahil edilmiştir. İki grup arasında serum YKL-40, hematolojik parametreler ve C reaktif protein (CRP) değerleri karşılaştırılmıştır.

Bulgular: Bruselloz hasta grubunda, YKL-40 değeri 15.0 ± 8.8 ng/mL, CRP 0.2 ± 0.1 mg/dL, Nötrofil/ Lenfosit oranı (NLR) 1.5 ± 1.0 ve Platelet/Lenfosit oranı (PLR) 109.3 ± 46.4 idi. Kontrol grubunda, YKL-40 değeri 12.7 ± 6.1ng/mL, CRP 1.48 ± 2.1mg/dL, Nötrofil/ Lenfosit oranı (NLR) 2.1 ± 0.7 ve Platelet/Lenfosit oranı (PLR) 147.8 ± 59.0 idi.

Sonuç: YKL-40 düzeylerinde hasta ve kontrol grubu arasında anlamlı bir fark bulunmamıştır. Hasta grubunda kontrol grubuna göre CRP anlamlı olarak yüksek, bunun yanında YKL-40 ile CRP, PLT, PLR, NLR ve yaş arasında pozitif korelasyon saptanmıştır. Ancak YKL-40’ ın enfeksiyon hastalıklarında rolünün daha iyi anlaşılabilmesi için ileri çalışmalara ihtiyaç vardır.

Anahtar Kelimeler

• Bruselloz,YKL-40,infeksiyon

Determination of serum YKL-40 levels in patients with brucellosis

Öz

Aim: To determine serum YKL-40 levels in patients diagnosed with brucellosis.

Material and Methods: This study included 40 Brucellosis patients with positive serum agglutination tests and 41 healthy control subjects. The two groups were compared with regard to their serum YKL-40, hematological parameters, and C-reactive protein (CRP) values.

Results: The brucellosis patient group presented YKL-40 values of 15.0 ± 8.8 ng/mL, CRP values of 0.2 ± 0.1 mg/dL, a Neutrophil/Lymphocyte ratio (NLR) of 1.5 ± 1.0, and a Platelet/Lymphocyte ratio (PLR) of 109.3 ± 46.4. The control group presented YKL-40 values of 12.7 ± 6.1ng/mL, CRP values of 1.48 ± 2.1mg/dL, a Neutrophil/Lymphocyte ratio (NLR) of 2.1 ± 0.7, and a Platelet/Lymphocyte ratio (PLR) of 147.8 ± 59.0.

Conclusion: No significant differences were determined between the YKL-40 levels of the patient and control groups. The patient group manifested significantly higher levels of CRP compared to the control group, and YKL-40 was determined to be positively correlated with CRP, PLT, PLR, NLR and age. However, further studies are needed for the role of YKL-40 in infectious diseases to be understood more clearly.

Anahtar Kelimeler

• brucellosis,YKL-40,diagnostic value

Kaynakça

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