İzole sol ventrikül noncompaction olan hastalarda miyokard dokusunun analizi

Öz

Amaç: Videodensitometrik miyokardiyal doku analizi (VMTA), çeşitli kardiyak hastalıklarda sol ventrikül (LV) disfonksiyonunu araştırmak için yaygın olarak kullanılmıştır. İzole sol ventrikül  noncompaction (IVNC) olan hastalar LV fonksiyonunda dalgalı bir düşüş yaşarlar. Bu çalışmanın amacı, bu hasta grubunda LV fonksiyonunun bozulmasını değerlendirmek için VMTA değerini değerlendirmektir.

 

Gereç ve Yöntemler: IVNC'li 25 hasta (10 asemptomatik [korunmuş LV fonksiyonu], 12 semptomatik [LV disfonksiyon]) ve 12 sağlıklı kontrol olacak şekilde değerlendirildi. Sistol sonunda ve diyastolde orta bazal LV duvarının 2 bölgesi (interventriküler septum [IVS] ve arka duvar [PW]) için arka plan düzeltmeli ortalama gri seviyelerini (BC-MGL) kaydetmek için videodensitometri kullanıldı. Her bölge için siklik varyasyon (CV) indeksi, formül CV'ye göre hesaplandı,  CV indeksi, % = ([[BC-MGL_end-diastol - BC-MGL _end-sistol]] ÷ BC- MGL_end-diastol) × 100.

 

Bulgular: Semptomatik IVNC grubundaki ortalama IVS-CV indeksi (% 12.3 ± 4.9), asemptomatik IVNC grubundaki (% 32.3 ± 14.8; p <0.05) ve kontrol grubundaki (% 36.6 ± 12.1) karşılık gelen bulgulardan anlamlı olarak düşüktü (p <0.001). Semptomatik gruptaki ortalama PW-CV indeksi (% 15.1 ± 5.5), asemptomatik (27.0 ± 10.4; p <0.05) ve kontrol gruplarındaki (28.8 ± 10.9; p <0.001) karşılık gelen değerlerden anlamlı olarak düşüktü.

 

Sonuç: VMTA, IVNC'li hastalarda LV miyokardiyumu değerlendirmek için konvansiyonel ekokardiyografiye pratik ve faydalı bir yardımcıdır. Azaltılmış CV indeks değerlerinin tespiti, bu grupta LV bozulmasının erken aşamalarını öngörebilir.

Anahtar Kelimeler

• videodensitometrik miyokardiyal doku analizi,izole sol ventrikül noncompaction kardiyomiyopati,kalp yetmezliği;,non-invaziv kalp görüntüleme

Analysis of myocardial texture in patients with isolated left ventricular noncompaction

Öz

Aim: Videodensitometric myocardial texture analysis (VMTA) has been widely used to investigate left ventricular (LV) dysfunction in various cardiac disorders. Patients with isolated left ventricular noncompaction (IVNC) experience an undulating decline in LV function. The aim of this study was to assess the value of VMTA for evaluating deterioration of LV function in this patient group.

Material and Methods: Twenty-two patients with IVNC (10 asymptomatic [preserved LV function], 12 symptomatic [LV dysfunction]) and 12 healthy controls were evaluated. Videodensitometry was used to record background-corrected mean gray levels (BC-MGL) for 2 regions of the mid-basal LV wall (the interventricular septum [IVS] and the posterior wall [PW]) at end-systole and end-diastole. The cyclic variation (CV) index for each region was calculated according to the formula, CV index % = ([BC-MGL_end-diastole – BC-MGL_end-systole] ÷ BC-MGL_end-diastole) × 100.

Results: The mean IVS-CV index in the symptomatic IVNC group (12.3 ± 4.9%) was significantly lower than the corresponding findings in the asymptomatic IVNC group (32.3 ± 14.8%, p < 0.05) and control group (36.6 ± 12.1%, p < 0.001). The mean PW-CV index in the symptomatic group (15.1 ± 5.5%) was also significantly lower than the corresponding values in the asymptomatic (27.0 ± 10.4%, p < 0.05) and control groups (28.8 ± 10.9%, p < 0.001).

Conclusion: VMTA is a practical, useful adjunct to conventional echocardiography for assessing LV myocardium in patients with IVNC. Detection of reduced CV index values might predict the early stages of LV deterioration in this group.

Anahtar Kelimeler

• videodensitometric myocardial texture analysis,isolated left ventricular noncompaction,cardiomyopathy,non-invasive cardiac imaging

Kaynakça

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