What about spike antibody levels in healthcare workers after COVID-19 vaccine?

Öz

Aim: The COVID 19 outbreak continues today with significant morbidity and mortality. Healthcare workers have the highest risk in this epidemic. Therefore, vaccination was first started from healthcare workers. In this study, we aimed to examine the antibody levels of healthcare workers after vaccination. Material and Methods: This is a retrospective study. A total of 102 healthcare workers who were given CoronaVac vaccine and whose antibody levels were checked after vaccination were included in the study. Results: The seventy seven (75.5%) of the cases were male, 25 (24.5%) were female, the mean age was 43.25 ± 9.97. 8 (7.8%) of the cases had previously had COVID-19. The mean antibody level was 1768.02 ± 3586.09. Antibody mean in women was 2127.9 ± 4716.1; it was 1651.2 ± 3163.8 in men. No statistical difference was found between age and gender and antibody level (Respectively; p=0.564, p=0.596). Conclusion: Post-vaccination antibody development was good among healthcare workers. All of the healthcare workers who had COVID-19 had an antibody response. There were only 3 individuals who did not develop antibody response.

Anahtar Kelimeler

• COVID 19
• healthcare workers
• vaccine
• antibody level

Sağlık Personelinde COVID-19 Aşısı Sonrası Spike Antikor Düzeyleri Ne Durumda?

Öz

Amaç: COVID 19 salgını günümüzde önemli bir morbidite ve mortalite ile devam etmektedir. Sağlık personeli bu salgında en yüksek riske sahiptir. O nedenle aşılamada ilk başta sağlık çalışanlarından başlanmıştır. Biz bu çalışmada aşı sonrası sağlık personellerinin antikor düzeyini irdelemeyi amaçladık. Gereç ve Yöntemler: Bu bir retrospektif çalışmadır. CoronaVac aşısı yapılan ve aşı sonrası antikor seviyesi bakılan toplam 102 sağlık personeli çalışmaya dahil edilmiştir. Bulgular: Vakaların 77 (%75.5)’si erkek, 25 (%24.5)’i kadın, yaş ortalaması 43,25±9,97 idi. Vakaların 8 (%7.8)’i daha önce COVID-19 geçirmişti. Ortalama antikor seviyesi 1768,02 ± 3586,09 idi. Kadınlarda antikor ortalaması 2127,9±4716,1; erkeklerde 1651,2±3163,8 idi. Fakat cinsiyet ile antikor seviyesi arasında fark yoktu (p=0.564). Yaş ve antikor seviyesi arasında da fark saptanmadı (p=0.596). Sonuç: Sağlık çalışanları arasında aşı sonrası antikor gelişimi iyiydi. COVID-19 geçiren sağlık çalışanlarının tümünde antikor yanıtı vardı. Populasyonda antikor yanıtı gelişmeyen sadece 3 kişi idi.

Anahtar Kelimeler

• COVID 19
• Sağlık personeli
• Aşı
• Antikor düzeyi

Kaynakça

1. 1. Self WH, Tenforde MW, Stubblefield WB et al. Decline in SARSCoV-2 Antibodies After Mild Infection Among Frontline Health Care Personnel in a Multistate Hospital Network - 12 States, April-August 2020. MMWR Morb Mortal Wkly Rep 2020; 69: 1762-6.
2. 2. Dan JM, Mateus J, Kato Y, et al. Immunological memory to SARSCoV-2 assessed for up to 8 months after infection. Science 2021; 371: 4063.
3. 3. Coronavirus (COVID-19) Update: Serological Tests. Food and Drug Administration. Erişim adresi: https://www.fda.gov/newsevents/ press-announcements/coronavirus-covid-19-updateserological-tests.
4. 4. https://www.cdc.gov/coronavirus/2019-ncov/vaccines/faq.html
5. 5. Hall V, Foulkes S, Charlett A, et al. Do antibody positive healthcare workers have lower SARS-CoV-2 infection rates than antibody negative healthcare workers? Large multi-centre prospective cohort study (the SIREN study), England: June to November 2020. 14 January 2021.
6. 6. Walker PGT, Whittaker C, Watson OJ. The impact of COVID-19 and strategies for mitigation and suppression in low- and middle-income countries. Science 2020; 369:413–22.
7. 7. Flaxman S, Mishra S, Gandy A. Estimating the effects of nonpharmaceutical interventions on COVID-19 in Europe. Nature 2020; 584:257–61.
8. 8. Sanche S, Lin YT, Xu C, Romero-Severson E, Hengartner N, Ke R. High contagiousness and rapid spread of severe acute respiratory syndrome coronavirus 2. Emerg Infect Dis 2020; 26: 1470–7.

9. 9. Lumley SF, O'Donnell D, Stoesser NE et al. Antibody Status and Incidence of SARS-CoV-2 Infection in Health Care Workers. N Engl J Med 2021; 384: 533-40.
10. 10. Lahner E, Dilaghi E, Prestigiacomo C, Alessio G, Marcellini L, Simmaco M. Prevalence of SARS-CoV-2 infection in health workers (HWs) and diagnostic test performance: the experience of a teaching hospital in central Italy. Int J Environ Res Public Health 2020; 17: 4417.
11. 11. Stubblefield WB, Talbot HK, Feldstein L, Tenforde MW, Rasheed MAU, Mills L. Seroprevalence of SARS-CoV-2 among frontline healthcare personnel during the first month of caring for COVID-19 patients - Nashville, Tennessee. Clin Infect Di. 2020