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Comparison of the postoperative first and fifth year outcomes in patients who had undergone thymectomy for Myastenia Gravis

Yıl 2015, Cilt: 6 Sayı: 2, 49 - 53, 14.09.2015
https://doi.org/10.18663/tjcl.59867

Öz

Aim: The efficiency of thymectomy for treating patients with Myasthenia gravis is a controversial issue. Thus, this study aimed to investigate the efficiency of thymectomy in the treatment of myasthenia gravis based on long-term follow-up results.Material and Methods: The first and fifth year clinical outcomes of 27 patients who had undergone median sternotomy and extended thymectomy for myasthenia gravis between January 1995 and January 2004 were compared statistically.Results: No statistically significant differences were found between the postoperative first and fifth year clinical outcomes of the patients.Conclusions: Thymectomy is a reliable method in the treatment of myasthenia gravis with respect to its long-term outcomes. The outcomes obtained at the end of the first and fifth year of thymectomy are not different

Kaynakça

  • Hohlfeld R, Wekerle H. The thymus in myasthenia gravis. Neurol Clin 1994; 12: 331-342.
  • Blalock A, Harvey AM, Ford FR, Lilienthal J Jr. The treatment of myasthenia gravis by removal of the thymus gland. JAMA 1941; 117: 1529-33.
  • Dural K, Yıldırım E, Han S, Ozısık K. The importance of the time interval between diagnosis and operation in myasthenia gravis patients. J Cardiovasc Surg 2003; 44; 125-9.
  • Jaretzki A, Barohn RJ, Ernstoff RM et al. Myasthenia gravis: recommendations for clinical research standarts. Ann Thorac Surg 2000; 70: 327-34.
  • Werneck LC, Cunha FMB, Scola RH. Myasthenia gravis: a retrospective study comparing thymectomy to conservative treatment. Acta Neurol Scand. 2000; 101: 41-6.
  • Hase R, Sugiura H, Fukunaga A, Takahashi H. Clinical outcomes following extended thymectomy for myasthenia gravis: report of 17 cases. Ann Thorac Cardiovasc Surg. 2006; 12: 203-6.
  • Yuan HK, Huang BS, Kung SY, Kao KP. The effectiveness of thymectomy on seronegative generalized myasthenia gravis: comparing with seropositive cases. Acta Neurol Scand 2007; 115: 181-4.
  • Ozdemir N, Kara M, Dikmen E, Nadir A. Predictors of clinical outcome following extended thymectomy in myasthenia gravis. Eur J Cardiothorac Surg 2003; 23: 233-7.
  • Shrager JB, Nathan D, Brinster CJ, Yousuf O. Outcomes after 151 extended transservical thymectomies for myasthenia gravis. Ann Thorac Surg 2006; 82: 1863-9.
  • Park IK, Choi SS, Lee JG, Kim DJ, Chung KY. Complete stable remission after extended transsternal thymectomy in myasthenia gravis. Eur J Cardiothorac Surg 2006; 30: 525-8.
  • Kawaguchi N, Kuwabara S, Nemoto Y, Fukutake T. Effects of thymectomy on late-onset myasthenia gravis without thymoma. Clin Neurol Neurosurg 2007; 109: 858-61.
  • Huang CS, Hsu HS, Huang BS, Lee HC. Factors influencing the outcome of transsternal thymectomy for myasthenia gravis. Acta Neurol Scand 2005; 112: 108-14.
  • Zielinski M, Kuzdzal J, Szlubowski A. Transservical-Subxiphoid-Videothorascopic “Maximal” thymectomy-operative technique and early results. Ann Thorac Surg 2004; 78: 404-10.
  • Zielinski M, Kuzdzal J, Szlubowski A, Soja J. Comparison of late results of basic transsternal and extended transsternal tymectomies in the treatment of myasthenia gravis. Ann Thorac Surgery 2004; 78: 253-8.
  • Kattach H, Anastasiadis K, Cleuziou J, Buckley C, Shine B. Transsternal thymectomy for myasthenia gravis; surgical outcome. Ann Thorac Surg 2006; 81: 305-8.
  • Masoaka A, Yamakawa Y, Niwa H, Fukai I. Extended thymectomy for myasthenia gravis patients; a 20-year review. Ann Thorac Surg. 1996; 62: 853-9.
  • Kim HK, Park MS, Choi YS, Kim K. Neurologic outcomes of thymectomy in myasthenia gravis: comperative analysis of the effect of thymoma. J Thorac Cardiovasc Surg. 2007; 134: 601-7.
  • Pompeo E, Nofroni I, Iavicoli N. Thorascopic completion thymectomy in refractory non-thymomatous myasthenia. Ann. Thorac Surg 2000; 70: 918-23.
  • Shrager J, Deeb M, Mick R, et al. Transcervical thymectomy for myasthenia gravis achieves results comparable to thymectomy by sternotomy. Ann Thorac Surg 2002; 74: 320-7.
  • Marulli G, Rea F. Myasthenia gravis and thymectomy: many doubts and few certainties. Eur J Cardiothorac Surg. 2014. doi: 10.1093/ejcts/ezu398.
  • Yu S, Li F, Chen B, et al. Eight-year follow-up of patients with myasthenia gravis after thymectomy. Acta Neurol Scand. 2015; 131:94-101.
  • Roth T, Ackermann R, Stein R, Inderbitzi R. Thirteen years follow-up after radical transsternal thymectomy for myasthenia gravis. Do short-term results predict long-term outcome? Eur J Cardiothorac Surg. 2002; 21: 664-70.

Myastenia Gravis için timektomi yapılan hastaların postoperatif birinci ve beşinci yıl sonuçlarının karşılaştırılması

Yıl 2015, Cilt: 6 Sayı: 2, 49 - 53, 14.09.2015
https://doi.org/10.18663/tjcl.59867

Öz

Amaç: Myastenia gravis hastalarının tedavisinde timektominin etkinliği tartışmalıdır. Bu çalışmada myastenia graviste
uzun dönem takip sonuçlarına göre timektomi etkinliğinin araştırılması amaçlandı.
Gereç ve Yöntemler: Ocak 1995 ile Ocak 2004 arasında myastenia gravis nedeniyle sternotomi ve ekstended timektomi
uygulanan 27 hastanın birinci ve beşinci yıllardaki klinik sonuçları istatistiksel olarak karşılaştırıldı.
Bulgular: Hastaların postoperatif birinci ve beşinci yıllardaki klinik sonuçları arasında istatistiksel fark saptanmadı.
Sonuçlar: Uzun dönem sonuçlarının iyi olması nedeniyle timektomi myastenia gravis tedavisinde güvenilir bir yöntemdir.
Timektomi sonrası birinci ve beşinci yıllar sonunda elde edilen sonuçlar arasında farklılık yoktur.

Kaynakça

  • Hohlfeld R, Wekerle H. The thymus in myasthenia gravis. Neurol Clin 1994; 12: 331-342.
  • Blalock A, Harvey AM, Ford FR, Lilienthal J Jr. The treatment of myasthenia gravis by removal of the thymus gland. JAMA 1941; 117: 1529-33.
  • Dural K, Yıldırım E, Han S, Ozısık K. The importance of the time interval between diagnosis and operation in myasthenia gravis patients. J Cardiovasc Surg 2003; 44; 125-9.
  • Jaretzki A, Barohn RJ, Ernstoff RM et al. Myasthenia gravis: recommendations for clinical research standarts. Ann Thorac Surg 2000; 70: 327-34.
  • Werneck LC, Cunha FMB, Scola RH. Myasthenia gravis: a retrospective study comparing thymectomy to conservative treatment. Acta Neurol Scand. 2000; 101: 41-6.
  • Hase R, Sugiura H, Fukunaga A, Takahashi H. Clinical outcomes following extended thymectomy for myasthenia gravis: report of 17 cases. Ann Thorac Cardiovasc Surg. 2006; 12: 203-6.
  • Yuan HK, Huang BS, Kung SY, Kao KP. The effectiveness of thymectomy on seronegative generalized myasthenia gravis: comparing with seropositive cases. Acta Neurol Scand 2007; 115: 181-4.
  • Ozdemir N, Kara M, Dikmen E, Nadir A. Predictors of clinical outcome following extended thymectomy in myasthenia gravis. Eur J Cardiothorac Surg 2003; 23: 233-7.
  • Shrager JB, Nathan D, Brinster CJ, Yousuf O. Outcomes after 151 extended transservical thymectomies for myasthenia gravis. Ann Thorac Surg 2006; 82: 1863-9.
  • Park IK, Choi SS, Lee JG, Kim DJ, Chung KY. Complete stable remission after extended transsternal thymectomy in myasthenia gravis. Eur J Cardiothorac Surg 2006; 30: 525-8.
  • Kawaguchi N, Kuwabara S, Nemoto Y, Fukutake T. Effects of thymectomy on late-onset myasthenia gravis without thymoma. Clin Neurol Neurosurg 2007; 109: 858-61.
  • Huang CS, Hsu HS, Huang BS, Lee HC. Factors influencing the outcome of transsternal thymectomy for myasthenia gravis. Acta Neurol Scand 2005; 112: 108-14.
  • Zielinski M, Kuzdzal J, Szlubowski A. Transservical-Subxiphoid-Videothorascopic “Maximal” thymectomy-operative technique and early results. Ann Thorac Surg 2004; 78: 404-10.
  • Zielinski M, Kuzdzal J, Szlubowski A, Soja J. Comparison of late results of basic transsternal and extended transsternal tymectomies in the treatment of myasthenia gravis. Ann Thorac Surgery 2004; 78: 253-8.
  • Kattach H, Anastasiadis K, Cleuziou J, Buckley C, Shine B. Transsternal thymectomy for myasthenia gravis; surgical outcome. Ann Thorac Surg 2006; 81: 305-8.
  • Masoaka A, Yamakawa Y, Niwa H, Fukai I. Extended thymectomy for myasthenia gravis patients; a 20-year review. Ann Thorac Surg. 1996; 62: 853-9.
  • Kim HK, Park MS, Choi YS, Kim K. Neurologic outcomes of thymectomy in myasthenia gravis: comperative analysis of the effect of thymoma. J Thorac Cardiovasc Surg. 2007; 134: 601-7.
  • Pompeo E, Nofroni I, Iavicoli N. Thorascopic completion thymectomy in refractory non-thymomatous myasthenia. Ann. Thorac Surg 2000; 70: 918-23.
  • Shrager J, Deeb M, Mick R, et al. Transcervical thymectomy for myasthenia gravis achieves results comparable to thymectomy by sternotomy. Ann Thorac Surg 2002; 74: 320-7.
  • Marulli G, Rea F. Myasthenia gravis and thymectomy: many doubts and few certainties. Eur J Cardiothorac Surg. 2014. doi: 10.1093/ejcts/ezu398.
  • Yu S, Li F, Chen B, et al. Eight-year follow-up of patients with myasthenia gravis after thymectomy. Acta Neurol Scand. 2015; 131:94-101.
  • Roth T, Ackermann R, Stein R, Inderbitzi R. Thirteen years follow-up after radical transsternal thymectomy for myasthenia gravis. Do short-term results predict long-term outcome? Eur J Cardiothorac Surg. 2002; 21: 664-70.
Toplam 22 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Sağlık Kurumları Yönetimi
Bölüm Özgün Makale
Yazarlar

Koray Dural

Nesimi Günal

Bülent Koçer

Gültekin Gülbahar Bu kişi benim

Bilge Koçer Bu kişi benim

Yayımlanma Tarihi 14 Eylül 2015
Yayımlandığı Sayı Yıl 2015 Cilt: 6 Sayı: 2

Kaynak Göster

APA Dural, K., Günal, N., Koçer, B., Gülbahar, G., vd. (2015). Comparison of the postoperative first and fifth year outcomes in patients who had undergone thymectomy for Myastenia Gravis. Turkish Journal of Clinics and Laboratory, 6(2), 49-53. https://doi.org/10.18663/tjcl.59867
AMA Dural K, Günal N, Koçer B, Gülbahar G, Koçer B. Comparison of the postoperative first and fifth year outcomes in patients who had undergone thymectomy for Myastenia Gravis. TJCL. Eylül 2015;6(2):49-53. doi:10.18663/tjcl.59867
Chicago Dural, Koray, Nesimi Günal, Bülent Koçer, Gültekin Gülbahar, ve Bilge Koçer. “Comparison of the Postoperative First and Fifth Year Outcomes in Patients Who Had Undergone Thymectomy for Myastenia Gravis”. Turkish Journal of Clinics and Laboratory 6, sy. 2 (Eylül 2015): 49-53. https://doi.org/10.18663/tjcl.59867.
EndNote Dural K, Günal N, Koçer B, Gülbahar G, Koçer B (01 Eylül 2015) Comparison of the postoperative first and fifth year outcomes in patients who had undergone thymectomy for Myastenia Gravis. Turkish Journal of Clinics and Laboratory 6 2 49–53.
IEEE K. Dural, N. Günal, B. Koçer, G. Gülbahar, ve B. Koçer, “Comparison of the postoperative first and fifth year outcomes in patients who had undergone thymectomy for Myastenia Gravis”, TJCL, c. 6, sy. 2, ss. 49–53, 2015, doi: 10.18663/tjcl.59867.
ISNAD Dural, Koray vd. “Comparison of the Postoperative First and Fifth Year Outcomes in Patients Who Had Undergone Thymectomy for Myastenia Gravis”. Turkish Journal of Clinics and Laboratory 6/2 (Eylül 2015), 49-53. https://doi.org/10.18663/tjcl.59867.
JAMA Dural K, Günal N, Koçer B, Gülbahar G, Koçer B. Comparison of the postoperative first and fifth year outcomes in patients who had undergone thymectomy for Myastenia Gravis. TJCL. 2015;6:49–53.
MLA Dural, Koray vd. “Comparison of the Postoperative First and Fifth Year Outcomes in Patients Who Had Undergone Thymectomy for Myastenia Gravis”. Turkish Journal of Clinics and Laboratory, c. 6, sy. 2, 2015, ss. 49-53, doi:10.18663/tjcl.59867.
Vancouver Dural K, Günal N, Koçer B, Gülbahar G, Koçer B. Comparison of the postoperative first and fifth year outcomes in patients who had undergone thymectomy for Myastenia Gravis. TJCL. 2015;6(2):49-53.


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