Leukopenia and thrombocytopenia due to metronidazole treatment in a case with acute gastroenteritis

Yıl 2017, Cilt: 8 Sayı: 1, 32 - 34, 16.03.2017

Özlem Özel Salih Cesur Çiğdem Ataman Hatipoğlu Şerife Altun Demircan Esra Kaya Kılıç Sami Kınıklı Ali Pekcan Demiröz

https://doi.org/10.18663/tjcl.298245

Öz

In cases with
gastroenteritis, the treatment is based on fluid and electrolyte replacement.
Antibacterial or antiparasite therapy could be given in cases where bacterial
or parasite microorganism is possible. However metronidazole therapy should not
be initiated empirically without parasitological evaluation of the feces.
Metronidazole is an antianaerobic and antiprotozoal effective drug and although
it is well tolerated, it can cause hematological and neurological adverse
effects in some patients.

Herein, we report an 84
years old male who has given metronidazole therapy with the diagnosis of acute
gastroenteritis and developed leukopenia and thrombocytopenia as side effects
of the therapy. It must be kept in mind that hematologic side effects such as
neutropenia and thrombocytopenia could occur during or after the metronidazole
therapy and those patients should be followed
closely.  

Anahtar Kelimeler

Acute gastroenteritis, metronidazole, thrombocytopenia, leukopenia, adverse effect

Metronidazol tedavisine bağlı olarak lökopeni ve trombositopeni gelişen akut gastroenterit olgusu

Öz

Akut gastroenteritlerde
tedavinin esası sıvı-elektrolit replasmanıdır. Bakteriyel veya paraziter etken
düşünülen olgularda ise antibiyotik veya antiparaziter tedavi uygulanabilir.
Gaitanın parazitolojik yönden incelemesi yapılmadan ampirik olarak metronidazol
tedavisi başlanmamalıdır. Metronidazol antianaerobik ve antiprotozoal etkili
bir ilaçtır, iyi tolere edilmesine rağmen bazı hastalarda hematolojik ve nörolojik
yan etkilere neden olabilmektedir.

Bu yazıda akut
gastroenterit tanısıyla metronidazol tedavisi başlanan ve metronidazole bağlı
yan etki olarak lökopeni ve trombositopeni gelişen 84 yaşında bir olgu
sunulmuştur. Metronidazol tedavisi sırasında veya sonrasında lökopeni,
trombositopeni gibi ilaca bağlı hematolojik yan etkilerin gelişebileceği akılda
tutulmalı ve yan etki gelişen hastalar yakından takip edilmelidir.

Anahtar Kelimeler

Akut gastroenterit, metronidazol, lökopeni, trombositopeni, yan etki

Kaynakça

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