The relationship between platelet to lymphocyte ratio and the diurnal variation of hypertension

Yıl 2020, Cilt: 11 Sayı: 2, 29 - 34, 21.03.2020

Savaş Çelebi

https://doi.org/10.18663/tjcl.648347

Öz

Aim:
Platelet to lymphocyte ratio (PLR) predicts worse outcome in cardiovascular
disease. However data is limitted about the role of PLR in the diurnal
variation of hypertension. In this study we evaluated the relationship between
the diurnal variation of hypertension and PLR.

Material and Methods:
The study included a total of 247 essential hypertensive patients. All patients
underwent 24-hour ambulatory blood monitoring. Thereafter hypertensive patients
were divided into two groups: 64 dipper patients (30 female, mean age 53.8±12.9
years) and 38 non-dipper patients (18 female, mean age 52.6±12.5years).
Complete blood count and biochemistry were measured by standard methods.  PLR was measured by dividing platelet count
to lymphocyte count.

Results:
Non-dipper hypertensives had signifi cantly higher PLR levels than dippers
(127.9±32.16 vs 103.4±10.67, p<0.001). There was a negatif correlation
between percentage of sistolic and diastolic blood pressure fall and PLR.

Conclusion:
We demonstrated that PLR, an inexpensive and easily accessible biomarker, is
significantly higher in nondipper hypertensives than the dipper hypertensives. 

Anahtar Kelimeler

Hypertension, non-dipper, dipper, platelet to lymphocyte ratio

Platelet lenfosit oranı ve hipertansiyonun diürnal ritmi arasındaki ilişki

Öz

Amaç: Platelet
lenfosit oranı (PLR) kardiyovasküler kötü sonlanımlar için öngördürücüdür.
Ancak PLR’nın hipertansiyonun diürnal ritmindeki rolü ile ilgili veri
sınırlıdır. Biz bu çalışmada PLR ile hipertansiyonun diürnal ritmi arasındaki
ilişkiyi değerlendirmeyi amaçladık.

Gereç ve Yöntemler: Çalışmaya
toplamda 247 esansiyel hipertansiyon hastası dahil edildi. Tüm hastalara
24-saat ambulatuar kan basıncı monitorizasyonu yapıldı. Takiben hastalar iki
gruba ayrıldı: 64 dipper hasta (30 kadın, ortalama yaş 53.8±12.9) ve 38
non-dipper hasta (18 kadın, ortalama yaş 52.6±12.5). Tam kan sayımı ve
biyokimyasl değerlendirme standart metodlarla yapıldı. PLR platelet sayısının
lenfosit sayısına bölünmesiyle hesaplandı.

Bulgular: Nondipper
hipertansifler dipper hipertansiflere kıyasla daha yüksek PLR’ye sahipti
(127.9±32.16’e 103.4±10.67, p<0.001). Sistolik ve diastolik kan basıncının
düşüş oranı ile PLR arasında negatif korelasyon mevcuttu.

Sonuç: Ucuz
ve kolay ulaşılabilir bir biobelirteç olan PLR, nondipper hipertansiflerde
dipper hipertansiflere kyasla daha yüksektir.

Anahtar Kelimeler

Hipertansiyon, non-dipper, dipper, platelet lenfosit oranı

Kaynakça

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