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Alopesi areata ve 25(OH) vitamin D

Yıl 2020, Cilt: 11 Sayı: 4, 220 - 224, 30.09.2020
https://doi.org/10.18663/tjcl.756143

Öz

Aim:To evaluate the status of serum 25-hydroxyvitamin D(25(OH)D) in patients with AA,serum 25(OH) D concentrations were compared with AA patients and healthy controls and thus determine if a possible association exists between serum 25(OH) D levels and AA.
Materials and Methods:The study comprising 43 patients diagnosed with AA and 69 healthy controls was conducted between October 2017 and March 2018.The serum vitamin D levels of the study group were determined by high performance liquid chromatography.Serum levels of calcium,phosphorus,alkaline phosphatase, and parathyroid hormone were also evaluated.
Results:The study was based on 43 patients aged between 10 and 47 (mean:33,41±7,2).The control group included 69 healthy persons aged between 18 and 55 (mean:33,53±7,2).Serum 25(OH)D levels in patients with AA ranged from 3,7 to 43,5 ng/ml with a mean of 20,21 ng/ml. Serum 25(OH)D levels in healthy controls ranged from 3 to 69,2 ng/ml with a mean of 24,09 ng/ml.There was no statistically difference in the serum vitamin D level between AA patients and healthy controls(p> 0.05)
Conclusion: In the light of these results, no relationship was found between AA and serum 25 (OH) vitamin D.

Kaynakça

  • 1.Alkhalifah A, Alsantali A, Wang E et al. Alopecia areata update: part I. Clinical picture, histopathology, and pathogenesis. J Am Acad Dermatol 2010; 62: 177–88.
  • 2.Gilhar A, Kalish RS. Alopecia areata: a tissue specific autoimmune disease of the hair follicle. Autoimmun Rev 2006; 5: 64–9.
  • 3.Kriegel MA, Manson JE, Costenbader KH. Does vitamin D affect risk of developing autoimmune disease? A systematic review. Semin Arthritis Rheum 2011; 40: 512–31.
  • 4.Hewison M. Vitamin D and the immune system: new perspectives on an old theme. Endocrinol Metab Clin North Am 2010; 39: 365–79.
  • 5.LoPiccolo MC, Lim HW. Vitamin D in health and disease. Photodermatol Photoimmunol Photomed 2010; 26: 224–9.
  • 6.Agmon-Levin N, Shoenfeld Y. Prediction and prevention of autoimmune skin disorder. Arch Dermatol Res 2009; 301: 57–64.
  • 7.Bergler-Czop B, Brzezińska-Wcisło L. Serum vitamin D level – the effect on the clinical course of psoriasis. Adv Dermatol Allergol 2016; 33: 445–9.
  • 8.Karagün E, Ergin C, Baysak S et al. The role of serum vitamin D levels in vitiligo. Adv Dermatol Allergol 2016; 33: 300–2.
  • 9.Kucharska A, Szmurło A, Sińska B. Significance of diet in treated and untreated acne vulgaris. Adv Dermatol Allergol 2016; 33: 81–6.
  • 10.Amano H, Abe M, Ishikawa O. First case report of topical tacalcitol for vitiligo repigmentation. Pediatr Dermatol 2008; 25: 262–4.
  • 11.Lips P, Hosking D, Lippuner K et al. The prevalance of vitamin D inadequacy among women with osteoporosis: an international epidemiological investigation. J Intern Med 2006; 260: 245–54.
  • 12.Yılmaz N, Serarslan G, Gokce C. Vitamin D concentrations are decreased in patients with alopecia areata. Vitam Trace Elem 2012; 1: 105–9.
  • 13.Mahamid M, Abu-Elhija O, Samamra M et al. Association between vitamin D levels and alopecia areata. Isr Med Assoc J 2014; 16: 367–70.
  • 14.Aksu Cerman A, Sarikaya Solak S, Kivanc Altunay I. Vitamin D deficiency in alopecia areata.Br J Dermatol.2014;170:1299–304.
  • 15.d’Ovidio R, Vessio M, d’Ovidio FD. Reduced level of 25-hydroxyvitamin D in chronic/relapsing alopecia areata.Dermatoendocrinol.2013;5:271–3.
  • 16.Marahatta S,Agrawal S,Khan S,et al.Study on Serum Vitamin D in Alopecia Areata Patients.J Nepal Health Res Counc.2019;17:21-5.
  • 17.gade VKV,Mony A,Munisamy M,et al.An investigation of vitamin D status in alopecia areata.Clin Exp Med.2018;18:577-84.
  • 18.Lee S,Kim BJ,Lee CH,et al.Increased prevalence of vitamin D deficiency in patients with alopecia areata:a systematic review and meta-analysis.J Eur Acad Dermatol Venereol.2018;32:1214-21.
  • 19.Hekimsoy Z, Dinç G, Kafesçiler S, et al. Vitamin D status among adults in the Aegean region of Turkey.BMC Public Health.2010;10:782.
  • 20.Orun E, Sezer S, Kanburoglu MK, et al. Vitamin D deficiency in healthy children and adolescent.Clin Invest Med.2015;38:E261–6.
  • 21.Van der Meer IM, Middelkoop BJ, Boeke AJ, Lips P. Prevalence of vitamin D deficiency among Turkish, Moroccan, Indian and Sub-Sahara African populations in Europe and their countries of origin: overview. Osteoporos Int 2011; 22: 1009–21.
  • 22.Holick MF. Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease. Am J Clin Nutr 2004; 80: 1678–88.
  • 23.Gannagé-Yared MH, Chemali R, Yaacoub N et al. Hypovitaminosis D in a sunny country: relation to lifestyle and bone markers. J Bone Miner Res 2000; 15: 1856–62.
  • 24.Mishal AA. Effects of different dress styles on vitamin D levels in healthy young Jordanian women. Osteoporos Int 2001; 12: 931–5.
  • 25.Lips P. Vitamin D status and nutrition in Europe and Asia. J Steroid Biochem Mol Biol 2007; 103: 620–5.

Alopesi areata ile serum 25(OH) d vitamini ilişkisi

Yıl 2020, Cilt: 11 Sayı: 4, 220 - 224, 30.09.2020
https://doi.org/10.18663/tjcl.756143

Öz

Amaç:Alopesi areata(AA) hastalarında serum 25-hidroksivitamin D (25 (OH) D) seviyelerini incelemek ve sağlıklı bireylerden oluşan kontrol grubu ile karşılaştırarak serum 25 (OH) D seviyeleri ile AA arasında olası bir ilişki olup olmadığı belirlemektir.
Gereç ve Yöntemler: Ekim 2017-Mart 2018 tarihleri arasında AA tanısı konulan 43 hasta ve 69 sağlıklı birey çalışmaya alındı.Çalışma grubunun serum D vitamini düzeyleri yüksek performans likit kromatografi yöntemi ile değerlendirildi.Ayrıca serum kalsiyum, fosfor, alkalen fosfataz ve paratiroid hormon seviyeleri de değerlendirildi.
Bulgular: Çalışmamıza 10-47 yaş(ortalama: 33.41 ± 7.2) arasındaki 43 hasta ve kontrol grubunda 18-55 yaş arası(ortalama: 33,53 ± 7.2). 69 sağlıklı birey katılmıştır. AA'lı hastalarda serum 25 (OH) D seviyeleri ortalama 20,21 ng / ml (3,7-43,5 ng / ml) olarak belirlendi. Kontrol grubunda ise serum 25 (OH) D seviyeleri ortalama 24,09 ng /ml(3-69,2 ng / ml) olarak belirlendi.. Her iki grup arasında serum D vitamini düzeyi arasında istatistiksel olarak anlamlı bir fark yoktu(p> 0.05).
Sonuç: Bu sonuçlar ışığında AA ile serum 25(OH) D vitamini arasında herhangi bir ilişki saptanmamıştır.

Kaynakça

  • 1.Alkhalifah A, Alsantali A, Wang E et al. Alopecia areata update: part I. Clinical picture, histopathology, and pathogenesis. J Am Acad Dermatol 2010; 62: 177–88.
  • 2.Gilhar A, Kalish RS. Alopecia areata: a tissue specific autoimmune disease of the hair follicle. Autoimmun Rev 2006; 5: 64–9.
  • 3.Kriegel MA, Manson JE, Costenbader KH. Does vitamin D affect risk of developing autoimmune disease? A systematic review. Semin Arthritis Rheum 2011; 40: 512–31.
  • 4.Hewison M. Vitamin D and the immune system: new perspectives on an old theme. Endocrinol Metab Clin North Am 2010; 39: 365–79.
  • 5.LoPiccolo MC, Lim HW. Vitamin D in health and disease. Photodermatol Photoimmunol Photomed 2010; 26: 224–9.
  • 6.Agmon-Levin N, Shoenfeld Y. Prediction and prevention of autoimmune skin disorder. Arch Dermatol Res 2009; 301: 57–64.
  • 7.Bergler-Czop B, Brzezińska-Wcisło L. Serum vitamin D level – the effect on the clinical course of psoriasis. Adv Dermatol Allergol 2016; 33: 445–9.
  • 8.Karagün E, Ergin C, Baysak S et al. The role of serum vitamin D levels in vitiligo. Adv Dermatol Allergol 2016; 33: 300–2.
  • 9.Kucharska A, Szmurło A, Sińska B. Significance of diet in treated and untreated acne vulgaris. Adv Dermatol Allergol 2016; 33: 81–6.
  • 10.Amano H, Abe M, Ishikawa O. First case report of topical tacalcitol for vitiligo repigmentation. Pediatr Dermatol 2008; 25: 262–4.
  • 11.Lips P, Hosking D, Lippuner K et al. The prevalance of vitamin D inadequacy among women with osteoporosis: an international epidemiological investigation. J Intern Med 2006; 260: 245–54.
  • 12.Yılmaz N, Serarslan G, Gokce C. Vitamin D concentrations are decreased in patients with alopecia areata. Vitam Trace Elem 2012; 1: 105–9.
  • 13.Mahamid M, Abu-Elhija O, Samamra M et al. Association between vitamin D levels and alopecia areata. Isr Med Assoc J 2014; 16: 367–70.
  • 14.Aksu Cerman A, Sarikaya Solak S, Kivanc Altunay I. Vitamin D deficiency in alopecia areata.Br J Dermatol.2014;170:1299–304.
  • 15.d’Ovidio R, Vessio M, d’Ovidio FD. Reduced level of 25-hydroxyvitamin D in chronic/relapsing alopecia areata.Dermatoendocrinol.2013;5:271–3.
  • 16.Marahatta S,Agrawal S,Khan S,et al.Study on Serum Vitamin D in Alopecia Areata Patients.J Nepal Health Res Counc.2019;17:21-5.
  • 17.gade VKV,Mony A,Munisamy M,et al.An investigation of vitamin D status in alopecia areata.Clin Exp Med.2018;18:577-84.
  • 18.Lee S,Kim BJ,Lee CH,et al.Increased prevalence of vitamin D deficiency in patients with alopecia areata:a systematic review and meta-analysis.J Eur Acad Dermatol Venereol.2018;32:1214-21.
  • 19.Hekimsoy Z, Dinç G, Kafesçiler S, et al. Vitamin D status among adults in the Aegean region of Turkey.BMC Public Health.2010;10:782.
  • 20.Orun E, Sezer S, Kanburoglu MK, et al. Vitamin D deficiency in healthy children and adolescent.Clin Invest Med.2015;38:E261–6.
  • 21.Van der Meer IM, Middelkoop BJ, Boeke AJ, Lips P. Prevalence of vitamin D deficiency among Turkish, Moroccan, Indian and Sub-Sahara African populations in Europe and their countries of origin: overview. Osteoporos Int 2011; 22: 1009–21.
  • 22.Holick MF. Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease. Am J Clin Nutr 2004; 80: 1678–88.
  • 23.Gannagé-Yared MH, Chemali R, Yaacoub N et al. Hypovitaminosis D in a sunny country: relation to lifestyle and bone markers. J Bone Miner Res 2000; 15: 1856–62.
  • 24.Mishal AA. Effects of different dress styles on vitamin D levels in healthy young Jordanian women. Osteoporos Int 2001; 12: 931–5.
  • 25.Lips P. Vitamin D status and nutrition in Europe and Asia. J Steroid Biochem Mol Biol 2007; 103: 620–5.
Toplam 25 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Sağlık Kurumları Yönetimi
Bölüm Özgün Makale
Yazarlar

Erdinç Terzi

Yayımlanma Tarihi 30 Eylül 2020
Yayımlandığı Sayı Yıl 2020 Cilt: 11 Sayı: 4

Kaynak Göster

APA Terzi, E. (2020). Alopesi areata ile serum 25(OH) d vitamini ilişkisi. Turkish Journal of Clinics and Laboratory, 11(4), 220-224. https://doi.org/10.18663/tjcl.756143
AMA Terzi E. Alopesi areata ile serum 25(OH) d vitamini ilişkisi. TJCL. Eylül 2020;11(4):220-224. doi:10.18663/tjcl.756143
Chicago Terzi, Erdinç. “Alopesi Areata Ile Serum 25(OH) D Vitamini ilişkisi”. Turkish Journal of Clinics and Laboratory 11, sy. 4 (Eylül 2020): 220-24. https://doi.org/10.18663/tjcl.756143.
EndNote Terzi E (01 Eylül 2020) Alopesi areata ile serum 25(OH) d vitamini ilişkisi. Turkish Journal of Clinics and Laboratory 11 4 220–224.
IEEE E. Terzi, “Alopesi areata ile serum 25(OH) d vitamini ilişkisi”, TJCL, c. 11, sy. 4, ss. 220–224, 2020, doi: 10.18663/tjcl.756143.
ISNAD Terzi, Erdinç. “Alopesi Areata Ile Serum 25(OH) D Vitamini ilişkisi”. Turkish Journal of Clinics and Laboratory 11/4 (Eylül 2020), 220-224. https://doi.org/10.18663/tjcl.756143.
JAMA Terzi E. Alopesi areata ile serum 25(OH) d vitamini ilişkisi. TJCL. 2020;11:220–224.
MLA Terzi, Erdinç. “Alopesi Areata Ile Serum 25(OH) D Vitamini ilişkisi”. Turkish Journal of Clinics and Laboratory, c. 11, sy. 4, 2020, ss. 220-4, doi:10.18663/tjcl.756143.
Vancouver Terzi E. Alopesi areata ile serum 25(OH) d vitamini ilişkisi. TJCL. 2020;11(4):220-4.


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