YAŞLILARDA PROTON POMPA İNHİBİTÖRÜ KULLANIMI VE RENAL FONKSİYONLARLA İLİŞKİSİ

Öz

Amaç: Son dönemlerde proton pompa inhibitörlerinin yan etkilerinden ve özellikle de renal etkilerinden daha sık söz edilmektedir. Akut tübülointerstisyel nefrit, akut böbrek hasarı, kronik böbrek hasarının progresyonu gibi klinik durumlara neden olabileceği düşünülmektedir. Biz bu çalışmamızda nefroloji polikliniğimize başvuran yaşlı hastalarda proton pompa inhibitörü kullanım sıklığını, proteinüri ve böbrek hasarıyla olan ilişkisini inceledik. Yöntem: Bir yıllık sürede nefroloji polikliniğine başvuran 75 yaş ve üzerindeki hastaların dosyaları incelenmiştir. Bulgular: 75 yaş ve üzeri nefroloji polikliniğine başvuran hastalarımızda proton pompa inhibitörü kullanma sıklığı yüksektir. Proton pompa inhibitörü kullanan yaşlı hastalarda kronik böbrek hasarı birlikteliği istatistiksel olarak anlamlı olmasa da daha sık bulunmuştur. Tartışma: Proton pompa inhibitörlerinin bilinçsiz ve/veya endikasyon dışı kullanımı renal fonksiyonlarda bozulmayla ilişkili olabilir. Proton pompa inhibitörü kullanmak zorunda olan hastalarda renal fonksiyonlar takip edilmelidir.

Anahtar Kelimeler

• Kronik böbrek hastalığı
• proton pompa inhibitörleri
• geriatri

ASSOCIATION OF PROTON PUMP INHIBITORS USE AND RENAL FUNCTIONS IN ELDERLY

Öz

Introduction: Recently, side effects and especially renal effects of proton pump inhibitors have been pronounced more frequently. It is thought that they may lead to clinical situations as acute tubulointerstitial nephritis, acute kidney injury and progression of chronic kidney injury. In this study, we investigated the frequency of proton pump inhibitor use and its association with proteinuria and kidney injury in older patients admitted to our nephrology outpatient clinic. Methods: The medical records of patients aged 75 years and older who applied to the nephrology outpatient clinic for a period of one year were examined. Results: The frequency of proton pump inhibitors use is high in our 75 years and older patients admitted to the nephrology outpatient clinic. In elderly patients using proton pump inhibitors, the association with chronic kidney injury was found to be more frequent, although not statistically significant. Conclusion: Unaware and/or off-label use of proton pump inhibitors may be associated with impaired renal function. Renal functions should be monitored in patients who have to use a proton pump inhibitor.

Anahtar Kelimeler

• Chronic kidney disease
• proton pump inhibitors
• geriatrics

Kaynakça

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