Evaluation of Potential Drug-drug Interactions in the Prescriptions in Outpatient Settings

Öz

Introduction: Drug-drug interactions (DDIs) are an important component of drug-related adverse events, leading to morbidity and mortality worldwide. The aim of the present study was to evaluate the frequency and severity of potential DDIs (pDDIs) in the prescriptions written in outpatient primary care clinics in Trabzon, Turkey. Material and Methods: A retrospective descriptive study was carried out in 169 prescriptions from 15 primary care clinics. pDDIs were identified by using Lexi-Interact™ software program. Results: A total of 169 prescriptions involving 506 drugs were analyzed, of which 59 had at least one pDDI. The prevalence of pDDIs was 34.91%. The mean number of drugs per prescription was 2.99±1.08. A total of 124 pDDIs were identified with mean of 0.73±1.45 per each prescription. Hydrochlorothiazide was the most frequently prescribed drug involved in pDDIs (n=15, 12.10%). The most common pDDIs was between hydrochlorothiazide and metformin (n=4, 3.22%). The number of pDDIs are positively correlated with increasing age (r=0.33 p<0.01) and the number of prescribed drugs (r=0.41, p<0.01). The majority of pDDIs (n=96, 77.42%) were in the risk category C (monitor therapy). Conclusion: Our findings indicate that polypharmacy and age were associated with the risk of having pDDIs. Physicians and pharmacists should be aware of pDDIs to improve drug safety, patient compliance and, prevent adverse drug reactions. Analyzing of DDIs with softwares should be effective for management of risks associated with pDDIs.

Anahtar Kelimeler

• drug use
• family practice
• polypharmacy
• primary care
• prescription

Ayaktan Tedavi Edilen Hasta Reçetelerinde Potansiyel İlaç-ilaç Etkileşimlerinin Değerlendirilmesi

Öz

Giriş:İlaç-ilaç etkileşimleri, dünya çapında morbidite ve mortaliteye yolaçan ilaçlarla ilgili advers olayların önemli bir bileşenidir. Bu çalışmada, Trabzon'da aile sağlığı merkezlerinde ayakta tedavi gören hastalara ait reçetelerdeki potansiyel ilaç-ilaç etkileşimlerinin yaygınlığını ve ciddiyetini değerlendirmek amaçlandı. Materyal ve Metot: Trabzon'da bulunan 15 farklı aile sağlığı merkezinden çıkmış olan 169 reçetede retrospektif tanımlayıcı bir çalışma yapıldı. Potansiyel ilaç-ilaç etkileşimleri Lexi-Interact™ programı kullanılarak analiz edildi. Bulgular: Beş yüz altı adet ilaç içeren toplam 169 reçetenin 59 tanesinde en az bir potansiyel etkileşim saptandı. Potansiyel ilaç-ilaç etkileşimi prevalansı %34.91 ve reçete başına düşen ortalama ilaç sayısı 2.99 ± 1.08 idi. Reçete başına ortalama 0.73±1.45 adet olmak üzere toplam 124 potansiyel etkileşim tanımlandı. Hidroklorotiyazid potansiyel ilaç etkileşimlerinde en fazla yer alan ilaçtı (n = 15,% 12.10). En yaygın potansiyel ilaç-ilaç etkileşimi hidroklorotiyazid ve metformin arasındaydı (n = 4,% 3.22). Potansiyel etkileşim sayısı ile hastaların yaşı (r = 0.33, p <0.01) ve ilaç sayısı (r = 0.41, p <0.01) arasında pozitif korelasyon mevcuttu. Etkileşimlerin büyük çoğunluğu C grubu (n=96, 77.42%) risk kategorisine aitti. Sonuç: Bulgularımıza göre polifarmasi ve ileri yaş, potansiyel ilaç-ilaç etkileşim riskini artırmaktadır. Hekimler ve eczacılar ilaç güvenliği ve hasta uyumunu iyileştirmek, ve olumsuz ilaç reaksiyonlarını önlemek için potansiyel etkileşimlerin farkında olmalıdır. İlaç-ilaç etkileşimlerinin yazılımlarla analiz edilmesi, potansiyel etkileşimlere ilişkili risklerin yönetimi için etkili olabilir.

Anahtar Kelimeler

• aile hekimliği
• etkileşim
• polifarmasi
• birincil bakım

Kaynakça

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