A Case of Timely Recognized Aortic Stenosis in Primary Health Care

Yıl 2013, Cilt: 7 Sayı: 4, 0 - 0, 01.12.2013

Muharrem Ak Murat Yüksel

Öz

Talasemi Minor’da Demir, Folik Asit ve B12 Eksikliği Prevalansı Talasemi taşıyıcılığına bağlı anemi bölgemizde sık karşılaşılan hematolojik bir problemdir ve demir eksikliği anemisi ile karışabilmektedir. Her ikisinin birlikte olduğu olgularda anemi daha da derinleşmesine rağmen konu ile ilgili kaynaklarda bilgiler yeteri kadar açık değildir. Bu çalışma, beta talasemi taşıyıcılığı tanısı alan hastaların besinsel durumunu (demir, folik asit ve vitamin B12) değerlendirmesi amacıyla yapılmıştır. Çalışmaya beta talasemi taşıyıcılığı tanısı almış alan 47’si erkek toplam 183 hasta alındı. Kadın hastaların %17.5 sinde ve erkeklerin % 1.6’sinde demir eksikliği olduğu tespit edildi. Vitamin B12 ve folik asit düşüklüğü sırasıyla %28.7, %10.3 olarak saptandı. Çalışmamız sonucunda takip edilen talasemi taşıyıcılığında eşlik eden demir eksikliği ve diğer besinsel anemilerin (vitamin b12 ve folik asit eksikliği) varlığının araştırılmasının yararlı olabileceği düşünülmektedir.

Anahtar Kelimeler

Beta Talasemi Minor, Demir Eksikliği Anemisi, B12 Vitamini, Folik Asit

A Case of Timely Recognized Aortic Stenosis in Primary Health Care

Öz

Prevalence of Iron, Folic Acid and Vitamin B12 Deficiency in Patients with Thalassemia Minor Thalassemia trait -related anemia is a common hematologic problem in Mediterranean region. This type of anemia may be frequently confused with iron deficiency anemia. Anemia becomes more severe in case of coexistence of both anemia types and literature knowledge is sparse on that issue. This study was carried out with the aim of investigation of iron, folic acid and vitamin B12 levels in patients who were diagnosed with beta thalassemia trait. A total of 183 patients (47 male, 136 female) who were diagnosed with beta thalassemia minor were enrolled in the study. Iron deficiency was detected in 17.5% of women and in 1.6% of men. Decreased vitamin B12 and folic acid values were detected as 28.7% and 10.3%, respectively. It was concluded that serum iron, folic acid and vitamin B12 levels should also be measured in assessment of talassemia trait patients due to its high prevalence in study region.

Anahtar Kelimeler

Beta Thalassemia Minor, Iron Deficiency Anemia, Vitamin B12, Folic Acid

Kaynakça

• Guvenc B, Canataroglu B, Unsal C, Yıldız SM, et al. Arch Med Sci 2012;8 (3): 411-4
• Koçak R, Alpaslan ZN, Ağrıdağ G, Baslamıslı F, et al. Eur J Epidemiol 1995;11(2)181-4.
• Hershko C, Konijn AM, Loria A. Serum ferritin and mean corpuscular volume measurement in the diagnosis of beta-thalassaemia minor and iron deficiency. Acta Haematol 1979;62(4):236-9.
• Hercberg S, Preziosi P, Galan P: Iron deficiency in Europe. Public Health Nutr 2001;4(2B):537–45.
• Clarke R, Grimley EJ, Schneede J, et al. Vitamin B12 and folate deficiency in later life. Age Ageing 2004;34–41.
• Hoorfar H, Sadrarhami S, Keshteli AH, Ardestani SK, Ataei M, Moafi A. Evaluation of iron status by serum ferritin level in Iranian carriers of beta thalassemia minor. Int J Vitam Nutr Res 2008;78(4,5):204-207.
• Genc A, Tasdemir KD, Urhan KM, et al. Prevalence of beta-thalassemia trait and abnormal hemoglobins in the province of Adıyaman, Turkey. Pediatr Hematol Oncol 2012;29(7):620-3.
• Kocak R, Paydas S. Pernicious anemia in Turkey. Int J Hematol 1992;55(2):117-9.
• Asma S, Boga C, Ozdogu H, Serin E. The association of phagophagia with Helicobacter pylori infection in patients with iron deficiency anemia. Int J Hematol 2009;90(1):28-32.
• Kosch M, Schaefer RM: Indications and practical management of parenteral iron therapy. Wien Klin Wochenschr 2003 24;115(11):380-4.
• Froom P, Aghai E, Quitt M, Yechiely H, Kahana L. Folate status in beta-thalassemia minor. Isr J Med Sci 1985;21(10):845-6.
• Asma S, Boga C, Ozdogu H. Safety, therapeutic effectiveness and cost of parenteral iron therapy. Int J Hematol 2009;90(1):24-7.
• Andrews NC: Disorders of iron metabolism. Blood, editors: Handın RI, Lux SE, Stossel TP, Lippincott Williams and Wilkins, Philadelphia, 2. Edt 2002; p:1400
• Tuphan KD, Nataraj. Prevalence of iron deficiency in thalassemia minor. A study from Tertiary Hospital. Indian J Hematol Blood Transfus 2012;28(1):7-9.
• Röth A. Megaloblastaere Anaemien. Herold G. In: Innere Medizin. Gerd Herold, Köln. 2007: 27-31. Mazzone A, Vezzoli M, Ottini E. Masked deficit of B(12) and folic acid in thalassemia. Am J Hematol 2001;67(4):274.
• Crayn, Elizabeth MD. Vitamin B12 deficiency; recognition and management. Primary Care Case Reviews 2002;5(2):53-60.
• Gümürdülü Y, Serin E, Özer B, Kayaselçuk F. Predictors of vitamin B12 deficiency: age and Helicobacter pylori load of antral mucosa. Turk J Gastroenterol2003;14(1):44-9.