THE EFFECTS OF FICUS CARICA SEED OIL ADMINISTRATION ON RENAL TAS, TOS, OSI, PON AND TOTAL THIOL VALUES IN RENAL ISCHEMIA REPERFUSION DAMAGE

Öz

Background and Objective: Renal ischemia-reperfusion is an important health condition that occurs for various reasons and causes kidney losses, and protective activities are especially important due to the short duration of the process. Studies with Ficus carica seed oil have shown that it has high antioxidant and anti-inflammatory effects. The aim of the study is to determine the protective effects of fig seed oil on renal ischemia-reperfusion injury. Material and Method: The study was formed by dividing 30 Wistar Albino rats into 3 groups as control, ischemia reperfusion and ischemia reperfusion group performed after intragastric administration of 3 ml/kg Ficus carica seed oil for 14 days. At the end of the study, TOS, TAS, OSI, PON and total thiol levels were biochemically measured from the kidney tissues. Results: Obtained results showed that 14-day fig seed oil application reduced oxidative damage (TOS, OSI) and increased antioxidant level (TAS, PON and total thiol) in kidneys exposed to ischemia-reperfusion injury statistically (p<0.05). Conclusion: It has been determined that fig seed oil provides protective properties due to its ability to reduce oxidative damage, and has positive effects against ischemia-reperfusion injury that can occur randomly.

Anahtar Kelimeler

• Antioxidant
• Ficus carica seed oil
• Oxidative damage
• Renal ischemia reperfusion damage

Kaynakça

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