The Effect of Peripheral Adropin Application on Hypothalamic Pituitary Adrenal Axis in Rats

Yıl 2019, Cilt: 4 Sayı: 2, 60 - 75, 28.10.2019

Mustafa Can Güler , Tuncer Nacar , Ersen Eraslan Ayhan Tanyeli , Elif Polat Selim Çomaklı

https://izlik.org/JA85NJ25HZ

Öz

Purpose:Hypothalamic pituitary adrenal (HPA) axis has many missions such as responses to stress and inflammatory factors. HPA axis is the primer stress response system. Adropin is a peptid structured hormone coded by energy homeostasis related gene. In this study biochemical, histopathologic and immunohistochemical effects of adropin hormone on HPA axis were examined.

Material and Method:Thirty two (32) Wistar Albinomale rats were used in the study. The rats were separated into 4 equal groups (n=8). The control group did not receive any applications; and the sham group was given adropin-dissolvent. Adropin was administered as intraperitoneal to the treatment groups at doses of 4 μg/kg and 40 μg/kg.The study lasted 10 days. On the 11^thday, the animals were sacrified, and relevant tissue samples were collected.

Findings:While cortisole, adrenaline, noradrenaline and serotonin levels decreased, contrary dopamin levels increased. There were no important changes on melatonin levels. As a consequence of immunohistochemical staining, CRH has shown increase in adropin groups compared to other groups.

Anahtar Kelimeler

Adropin , HPA Axis , Hormone , Inflammatory , Stress

Destekleyen Kurum

Department of Scientific Research Projects of Atatürk University

Proje Numarası

2016/64

Kaynakça

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