Aort ve Mitral Kapak Replasmanı Yapılan Bir Hastada Amiodarona Bağlı Gelişen Tiroid Disfonksiyonu

Öz

Amiodaron iyi bilinen benzofuranik derives! bir anti-aritmik ilaçtır ve içerdiği yüksek iyot konsantrasyonu nedeniyle tiroid disfonksiyonu oluşturma potansiyeli fazladır. Amiodaron hem ventriküler hem de atriyal aritmilerin tedavisinde sıklıkla kullanılır. Kardiyak yan etkileri diğer antiaritmiklere göre daha az sıklıkla ortaya çıkar. Tiroid fizyolojisi üzerine potansiyel belirgin bir etkisi mevcuttur. Burada 66 yaşında açık kalp cerrahisi sonrası antiaritmik ilaç olarak amiodaron verilen ve cerrahiden sonra tiroid disfonksiyonu geliştiren kadın bir olgu sunulmuştur.

Anahtar Kelimeler

• Amiodaron
• tiroid disfonksiyonu
• açık kalp cerrahisi

Amiodarone Induced Thyroid Dysfunction In a Patient Who Underwent Aortic and Mitral Valve Replacement: Case Report

Öz

Amiodarone is well recognized benzofuranic-derivative as an anti-arrhythmic drug containing a high dose of iodine with considerable potential to cause thyroid dysfunction. Amiodarone is often used to treat both ventricular and atrial arrhythmias. Its cardiac side effects are less frequent than those associated with other antiarrhythmics. It has potentially marked effects on thyroid physiology. The present patient was a 66-year-old woman who developed thyroid dysfunction and was given amiodarone as an anti-arrhythmic agent for cardiac arrhythmia after open heart surgery.

Anahtar Kelimeler

• Amiodarone
• thyroid dysfunction
• open heart surgery

Kaynakça

1. 1. Pavan R, Jesus AM, Maciel LM. Amiodarone and the thyroid. Arq Bras Endocrinol Metab 2004;48:176-82.
2. 2. Ursella S, Testa A, Mazzone M, Gentiloni Sil-veri N. Amiodarone-induced thyroid dysfunction in clinical practice. Eur Rev Med Pharmacol Sci 2006;10:269-78.
3. 3. Alyan O, Arda K, Ozdemir O, Acu B, Soylu M, Demirkan D. Differential diagnosis and clinical course of amiodarone-induced thyroid dysfunction. Med Sci Monit 2003;9(9):117-22 I REFERENCES
4. 4. Berger Y, Harris L. Pharmacokinetics. In: Harris L, Roncucci R, eds. Amiodarone. Paris: Medicine et Sciences Internationales 1986:45-98.
5. 5. Kucharczyk P, Michalkiewicz D, Kucharczyk A. The effects of amiodaron on the thyroid function. Pol Merkür Lekarski 2006;21:86-9.
6. 6. Vinzio S, Brafin-Busch MS, Schlienger JL, Go-ichot B. Cardiac consequences of clinical dys-thyroidism. Pathophysiological, clinical, and epidemiologic data. Presse Med 2005 24;34:1153-60
7. 7. lervasi G, Clerico A, Bonini R, Manfredi C, Berti S, Ravani M, Palmieri C, Carpi A, Biagi-ni A, Chopra IJ. Acute effects of amiodarone administration on thyroid function in patients with cardiac arrhythmia. J Clin Endocrinol Metab 1997;82:275-80.
8. 8. O'Sullivan AJ, Lewis M, Diamond T. Amiodarone-induced thyrotoxicosis: left ventricular dysfunction is associated with increased mortality. Eur J Endocrinol 2006;154:533-6.