Postmenopozal Türk Kadınlarında Osteoporotik Kırık Gelişiminde Kollajen I A 1 ve Vitamin D Reseptör Gen Polimorfizmlerinin Rolü

Öz

Bu çalışmanın amacı postmenopozal Türk kadınlarında COLIA1 Spl ve VDR BsmI polimorfizmi ve kırık riski arasındaki ilişkiyi araştırmaktır. Aralarında akrabalık bulunmayan 90 kadın bu çalışmaya alındı. Tüm hastalar postmenapozal dönemde idi. Osteoporoz tanısı WHO kriterlerine göre koyuldu. Bu hastaların 30’ unda osteoporoz mevcuttu ve kalça ve/veya vertebral fraktür gelişmişti, 30 hastada osteoporoz mevcut ancak fraktür öyküsü yoktu, 30 hasta bu hastalarla aynı yaş grubunda idi ve osteoporoz ve fraktür mevcut değildi. COLIA1 gen polimorfizmi SS, Ss and ss olarak, VDR BsmI gen polimorfizmi BB, Bb, and bb olarak tanımlandı. Çalışma grubunun genotipik dağılımı ile BMD ve fraktür varlığı arasındaki ilişki istatistiksel olarak değerlendirildi. Gruplara göre COLIA1 Spl allel dağılımı değerlendirildiğinde alicilerinin sıklığı açısından gruplar arasında istatistiksel olarak anlamlı farklılığın olmadığı görüldü (p= 0.092). Benzer şekilde VDR BsmI allel dağılımı değerlendirildiğinde, alellerinin sıklığı üç grupta da benzerdi (p= 0.563). COLIA1 Spl ve VDR BsmI allel dağılımının kırık varlığı ile ilişkisinin değerlendirilmesinde Grup 2+Grup 3 verileri Grup 1 ile karşılaştırıldı. Buna göre COLIA1 ve VDR gen polimorfizmlerinin sıklığı açısından gruplar arasında farklılık olmadığı izlendi (COLIA1 için, p=0.352; VDR için, p= 0.946). Benzer şekilde osteoporoz varlığı ile allel dağılımının ilişkisini değerlendirmek için Grupl+Grup2 verileri Grup 3 ile karşılaştırıldı. Her iki gene ait allel dağılımları için gruplar arasında anlamlı fark saptanmadı (COLIA1 için, p=0.436; VDR için, p=0.635). Sonuç olarak postmenopozal Türk kadınlarında COLIA1 ve VDR genleri osteoporoz ve kırık riski ile ilişkili bulunmamıştır.

Anahtar Kelimeler

• Osteoporoz; fraktür; COLIA1; vitamin D reseptörü
• Osteoporoz; fraktür
• COLIA1
• vitamin D reseptörü

The Role of Collagen I A 1 and Vitamin D Receptor Genes Polymorphisms on the Risk of Osteoporotic Fractures in Postmenopausal Turkish Women

Öz

The objective of this study was to investigate the relationship between COLIA 1 Spl and VDR BsmI polymorphisms and fracture risk in postmenopausal Turkish women. Ninety unrelated females were included in this study. All of these patients were in postmenopausal period. The diagnosis of osteoporosis was done according to WHO criteria. Thirty of them had osteoporosis and also with hip and/or vertebral fracture, 30 of them had osteoporosis but without fracture history and 30 individuals in similar age group had neither osteoporosis nor fracture. COLIA 1 gene polymorphisms were defined as SS, Ss, and ss. VDR BsmI gene polymorphisms were defined as BB, Bb, and bb. The relationship between genotypic distribution, BMD, and presence of fracture was evaluated statistically. When distribution of COLIA Spl allele was evaluated according to groups, there was no statistically significant difference in frequency of alleles between the groups (p=0.092). Also VDR BsmI allele distribution was evaluated, in all 3 groups frequency of alleles was similar (p=0.563). Relationship between COLIA1 Spl and VDR BsmI allele distribution and presence of fracture was evaluated. Data of Group II and Group III was compared with data of Group I. There was no difference in frequency of COLIA 1 and VDR gene polymorphisms between these groups (for COLIA1 p=0.352, for VDR p=0.946). Similarly relationship between presence of osteoporosis and allele distribution was evaluated. Data of Group I +Group II was compared with data of Group III. Allele distribution of both genes was not significantly different in groups (for COLIA 1 p=0.436. for VDR p=0.635). In conclusion, COLIA1 and VDR genes are not associated with fracture risk and BMD in postmenopausal Turkish women. Reyhan ERSOY, Bekir ÇAKIR, Mahmut UĞURLU, Oya TOPALOĞLU, Ayşenur UĞURLU, MD, Meryem KURU, Kasım KILIÇARSLAN, Bülent BEKTAŞER, Semra BAYKAL, Mehmet GÜMÜŞ,

Anahtar Kelimeler

• Osteoporosis; fracture; COLIA1; Vitamin D Receptor
• ,genses
• a1,

Kaynakça

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