PREVALANCE OF AUTOIMMUNE THYROID DISEASE IN CELIAC DISEASE

Öz

Celiac is an immunological disease induced by gliadine in susceptible individuals. It is well known that autoimmune thyroid diseases are common in patients with celiac disease. The aim of this study is to determine the frequency of autoimmune thyroid disease among patients with celiac disease in our region by evaluating thyroid function tests and autoimmune thyroid markers. Forty patients, diagnosed with celiac disease by endoscopic duodenal biopsy in our Gastroenterology Clinics Endoscopy Unit between January 2007- September 2008, were included in the study. Of all patients, 29 were female and 11 were male. Their mean age was 38,9 years (18-77). In the present study, frequency of autoimmune thyroid disease accompanied to celiac disease were 27.5% (n=11) of the patients. The patients who had autoimmune thyroid disease were women. Also thyroid function disorder was detected in three patients with autoimmune thyroid disease. As a result, it is important to examine celiac patients in terms of thyroid disease owing to the fact that autoimmune thyroid disease incidence is high and thyroid function disorder may develop among these patients.

Anahtar Kelimeler

• Celiac disease
• autoimmune thyroid disease
• endoscopy

ÇÖLYAK HASTALIĞINDA OTOİMMÜN TİROİD HASTALIĞI SIKLIĞI

Öz

Çölyak Hastalığı, genetik yatkınlığı olan hastalarda gliadin tarafından tetiklenen immünolojik bir hastalıktır. Otoimmün tiroid hastalıklarının Çölyak hastalığında sık görüldüğü bilinmektedir. Bu çalışmanın amacı bölgemizdeki Çölyak hastalığına sahip hastalarda tiroid fonksiyon testlerini ve otoimmün tiroid belirteçlerini değerlendirerek otoimmün tiroid hastalığı sıklığını belirlemekti. Çalışmaya Ocak 2007 ile Eylül 2008 tarihleri arasında Gastroenteroloji Kliniği, Endoskopi ünitesinde yapılan endoskopilerde alınan duodenal biyopsi sonucu Çölyak hastalığı tanısı konulan 40 hasta alındı. Çalışmaya alınan hastaların 29’u kadın, 11'i erkek ve yaş ortalaması 38,9 (18-77) idi. Bu çalışmada Çölyak hastalığına otoimmün tiroid hastalığının eşlik etme sıklığı %27,5 olarak bulundu (11/40) ve tiroid hastalığı tespit edilen hastaların hepsi kadın idi. Otoimmün tiroid hastalığı saptanan hastaların 3’ünde tiroid fonksiyon testlerinde bozukluk tespit edildi. Sonuç olarak Çölyak hastalığı olan bireylerde otoimmün tiroid hastalığı sıklığının yüksek olması ve bu bireylerde tiroid fonksiyon bozukluğu gelişebileceğinden, bu hastaların tiroid hastalığı yönünden değerlendirilmesi uygun olacaktır. Dr. Tuncer KILIÇ1, Dr. Atilla AYBAR. Dr. Ünal KILIÇ, Dr. Emel Özge KARAKAYA, Dr. Aylin Bolat DEMİREZER, Dr. Reyhan ERSO1, Dr. Osman ERSOY, Dr. Bekir ÇAKIR,

Anahtar Kelimeler

• Çölyak hastalığı
• otoimmün tiroid hastalığı
• endoskopi

Kaynakça

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