NON-METASTATİK RABDOMİYOSARKOM: TEK MERKEZ TEDAVİ SONUÇLARI VE KLİNİK ÖZELLİKLER

Öz

Merkezimize 1994-2007 yılları arasında başvuran otuz bir non-metastatik rabdomiy-osarkomlu hasta retrospektif olarak değerlendirildi. Hastalar; genel özellikleri ve sağkalım sonuçları açısından incelenerek literatürdeki serilerle karşılaştırıldı. Hastaların median yaşı 7, erkek/kız oranı 4.1 bulundu. En sık ekstremite yerleşimli tümörler görülürken, en sık rastlanan tümör histopatolojisi %51.6 ile embriyonel tip idi. Tümör evresi olarak %29 hasta İRS Grup 1, %29 hasta Grup 2 ve %42 hasta Grup 3’te yer aldı. Tanı anında %48.4 hastada tam ve tama yakın rezeksiyon gerçekleştirildi. Onyedi hasta EVAIA protokolü, sekiz hasta VACA protokolü ve altı hasta diğer protokoller ile tedavi edildi. Hastaların beş yıllık olaysız (EFS) ve genel yaşam hızları (OS) %50 ve %67 bulundu. Hastalarımızda genellikle kötü yerleşimli tümörler mevcut olmasına rağmen, elde edilen yaşam hızları gelişmiş ülkeler ile karşılaştırılabilir düzeydedir. Dr. Neriman SARP, Dr. Tuba EREN, Dr. Şule YEŞİL, Dr. İnci Ergürhan İLHAN

Anahtar Kelimeler

• Rabdomiyosarkom
• çocuk
• BEBEK

NON-METASTATIC RHABDOMYOSARCOMA: TREATMENT RESULTS OF SINGLE CENTER AND CLINICAL FEATURES

Öz

Thirty-one patients with non-metastatic rhabdomyosarcoma treated at Pediatric Oncology Department between 1994-2007 were reviewed retrospectively. Median age of the patients was 7. Male/female ratio was 4.1. Extremities were the most common location sites. Embryonal type was the most common histology. According to Intergroup Rhabdomyosarcoma Study Clinical Grouping system, 29% of the patients were group 1,29% of the patients were Group 2 and 42% of the patients were Group 3. Complete resection was performed at 48.4% of the patients. Seventeen patients were treated with EVAIA chemotherapy regimen, eight of them with VACA and the rest were treated with other regimens. Five-year event free survival and overall survival rates were 50% and 67%. Although most of our patients had poor prognostic location sites, the survival rates are comparable with developed countries.

Anahtar Kelimeler

• Rhabdomyosarcoma
• children
• baby

Kaynakça

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