Microbiota and Diabetes: Recent Findings and Mechanistic Approaches

Öz

The gut microbiota plays a pivotal role in the pathogenesis of metabolic diseases such as diabetes. This review examines the relationship between microbiota composition and type 2 diabetes mellitus (T2DM) based on current literature. The effects of microbial dysbiosis on insulin resistance, glucose metabolism, and inflammatory pathways are highlighted. Additionally, the potential of microbiota modulators (e.g., diet and probiotics) in diabetes management is discussed. Evidence suggests that microbiota-targeted therapies hold promise for diabetes prevention and treatment.

Anahtar Kelimeler

• Diet
• Dysbiosis
• Gut microbiota
• Probiotics
• Type 2 diabetes

Mikrobiyota ve Diyabet : Güncel Bulgular ve Mekanistik Yaklaşımlar

Öz

Bağırsak mikrobiyotası, diyabet gibi metabolik hastalıkların patogenezinde kritik bir rol oynamaktadır. Bu derlemede, mikrobiyota kompozisyonundaki değişimlerin tip 2 diyabet (T2DM) ile olan ilişkisi güncel literatür eşliğinde incelenmiştir. Mikrobiyal disbiyozun insülin direnci, glikoz metabolizması ve inflamatuvar süreçler üzerindeki etkileri vurgulanmıştır. Ayrıca, diyet ve probiyotikler gibi mikrobiyota modülatörlerinin diyabet yönetimindeki potansiyeli tartışılmıştır. Sonuç olarak, mikrobiyota temelli tedavi stratejilerinin diyabetin önlenmesi ve tedavisinde umut vaat ettiği görülmektedir.

Anahtar Kelimeler

• Bağırsak mikrobiyotası
• Disbiyoz
• Diyet
• Probiyotikler
• Tip 2 diyabet

Kaynakça

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