Fibromiyalji Sendromunda Otonom Disfonksiyonun Uyku Kalitesi Üzerine Etkisi

Öz

Amaç: Fibromiyalji Sendromu (FMS), yaygın ağrı, yorgunluk ve dinlendirici olmayan uyku ile karakterizedir. Otonom sinir sistemi düzensizliği, özellikle uyku bozukluğu olmak üzere bu semptomların şiddetinde rol oynayabilir. Bu çalışmanın amacı, FMS’li bireylerde otonom disfonksiyonun uyku kalitesi üzerine etkisini araştırmaktır. Yöntem: Bu çalışma Ocak–Mayıs 2025 tarihleri arasında yürütülmüş kesitsel bir araştırmadır. Çalışmaya, ACR 2016 kriterlerine göre FMS tanısı almış 40 kadın hasta ile yaş ve cinsiyet açısından eşleştirilmiş 40 sağlıklı bireyden oluşan kontrol grubu dahil edilmiştir. Katılımcılara Pittsburgh Uyku Kalitesi İndeksi (PUKİ), Kompozit Otonom Semptom Skoru-31 (COMPASS-31) ve Fibromiyalji Etki Anketi (FIQ) uygulanmıştır. Bulgular: FMS grubunun PUKİ, COMPASS-31 ve FIQ puanları kontrol grubuna kıyasla anlamlı derecede yüksek bulunmuştur (p<0,001). Regresyon analizinde COMPASS-31 puanının PUKİ puanının anlamlı bir yordayıcısı olduğu saptanmıştır (B=0,278, p<0,001). Ayrıca FMS grubunda COMPASS-31 ile PUKİ puanları arasında anlamlı pozitif korelasyon bulunmuştur (r=0,448, p<0,05). Sonuç: Bu çalışma, FMS’li bireylerin sağlıklı bireylere kıyasla anlamlı düzeyde artmış otonom disfonksiyon ve bozulmuş uyku kalitesine sahip olduğunu ortaya koymuştur. Otonom disfonksiyon düzeyi arttıkça uyku kalitesinde belirgin bir düşüş gözlenmektedir. Bu bulgu, otonom sinir sistemi bozukluklarının FMS semptomlarının gelişiminde ve şiddetlenmesinde merkezi bir rol oynayabileceğini desteklemektedir.

Anahtar Kelimeler

• Fibromiyalji Sendromu
• Otonom Disfonksiyon
• Uyku Kalitesi

The Effect of Autonomic Dysfunction on Sleep Quality in Fibromyalgia Syndrome

Öz

Objective: Fibromyalgia Syndrome (FMS) is characterized by widespread pain, fatigue, and non-restorative sleep. Dysregulation of the autonomic nervous system may play a role in the severity of these symptoms, particularly sleep impairment. This study aimed to investigate the effect of autonomic dysfunction on sleep quality in individuals with FMS. Methods: The study is a cross-sectional study conducted between January and May 2025, including 40 female patients diagnosed with FMS according to the ACR 2016 criteria, and a control group of 40 healthy individuals matched for age and gender. Participants were administered the Pittsburgh Sleep Quality Index (PSQI), the Composite Autonomic Symptom Score-31 (COMPASS-31), and the Fibromyalgia Impact Questionnaire (FIQ). Results: The FMS group had significantly higher PSQI, COMPASS-31, and FIQ scores compared to the control group (p<0.001). Regression analysis revealed that the COMPASS-31 score was a significant predictor of PSQI score (B=0.278, p<0.001). Additionally, a significant positive correlation was found between COMPASS-31 and PSQI scores in the FMS group (r=0.448, p<0.05). Conclusion: This study revealed that FMS exhibit significantly increased levels of autonomic dysfunction and impaired sleep quality compared to healthy individuals. As the level of autonomic dysfunction increases, a significant decline in sleep quality is observed. This finding supports the notion that autonomic nervous system disorders may play a central role in the development and exacerbation of FMS symptoms.

Anahtar Kelimeler

• Fibromyalgia Syndrome
• Autonomic Dysfunction
• Sleep Quality

Kaynakça

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