What happens to coagulation thrombosis mechanism in liver diseases?

Öz

Children with liver disease present complex and varied acquired coagulation abnormalities Liver is the place where clotting factors are produced as well as inhibitors of coagulation and fibrinolytic system components Although 75 85 of patients with liver disease show abnormal laboratory values only 10 15 will have clinical bleeding symptoms as liver has a large factor reserve capacity This paper will review acute and chronic liver disease and the hemostatic alterations Treatment of the coagulopaty of liver disease is usually replacement of lacking factor and supportive care Liver transplantation which is very common recently and its affects on hematological balance will also summarized Turk Arch Ped 2013; 48: 94 101

Anahtar Kelimeler

• Hemorrage, liver disease, thrombosis, treatment

Karaciğer hastalıklarında pıhtılaşma tromboz mekanizmasına neler oluyor?

Öz

Karaciğer hastalığı olan çocuklar karışık ve değişken pıhtılaşma bozuklukları gösterirler Pıhtılaşma faktörleri gibi pıhtılaşmayı engelleyen faktörler ve fibrinoliz karaciğerde yapılır Karaciğer hastalarının 75 85 rsquo;inde laboratuvarda bozukluk olsa da bu hastaların 10 15 rsquo;inde klinik kanama bulgusu vardır çünkü bu faktörler için karaciğerin geniş bir birikimi söz konusudur Bu yazıda akut ve kronik karaciğer hastalıklarında karaciğerin hemostatik özelliklerinden bahsedilecektir Karaciğer hastasının kanamasında genellikle eksik olan faktörün yerine konulması ve destek tedavisi önem kazanır Son yıllarda artan sayıda yapılan karaciğer nakli ve hematolojik sonuçlarından da bahsedilecektir.

Anahtar Kelimeler

• Karaciğer hastalıkları
• kanama
• tromboz
• tedavi

Kaynakça

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