Neonatal morbidity and mortality results in preterm premature rupture of membranes

Abstract

Aim: To investigate the effect of whole body hypothermia on short term neonatal morbidities and long term neurodevelopmental outcome in term neonates with hypoxic ischemic encephalopathy Material and Method: Neonates with perinatal asphyxia and hypoxic ischemic encepholopathy stage 2 and 3 were enrolled Patients were divided into 2 groups according to findings observed on amplitude integrated electroencephalography aEEG Patients with abnormal aEEG pattern in the first six hours after birth were defined as group 1 and others as group 2 Patients in group 1 were treated with whole body hypothermia Neurodevelopmental outcome was evaluated at 18 months of age in survivors using Bayley Scales of Infant Development II Mental developmental index and psychomotor development index scores were calculated Results: Thirty five patients were enrolled M F=17 18 18 51 of whom were treated with hypothermia Bradycardia was observed in 44 4 of patients in group 1 and 5 9 of patients in group 2 p=0 04 Incidence of other possible adverse events related to hypothermia were similar between the two groups Mortality was higher in group 1 p=0 03 In group 1 70 of the patients and in group 2 86 of the patients were evaluated using Bayley Scales of Infant Development II Although patients treated with hypothermia had a higher mental developmental index and psychomotor development index scores the difference was not statistically significant Conclusions: Whole body hypothermia can be safely applied in term neonates with HIE Hypothermia may improve neurodevelopmental outcome Turk Arch Ped 2011; 46: 286 91

Keywords

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Preterm erken membran rüptürü olgularında yenidoğan hastalık ve ölüm oranı sonuçları

Öz

Amaç: Preterm erken membran rüptürü olgularında yenidoğan hastalık ve ölüm oranı sonuçlarını araştırmaktır Gereç ve Yöntem: Preterm erken mebran rüptürü tanısı ile 1996 2005 yılları arasında kliniğimizde takip edilen 228 tekiz gebelik geriye dönük incelendi.

Bulgular: Preterm erken mebran rüptüründe en sık görülen yenidoğan hastalıkları sıkıntılı solunum sendromu SSS sepsis ve ventrikül içi kanamadır VİK Olgularında doğum şekli yenidoğan yoğun bakım birimi YYBB gereksinimi perinatal asfiksi sepsis ve VİK oranlarını etkilememektedir APGAR skoru lt;5 olduğunda YYBB ve pozitif basınçlı ventilasyon gereksinimi SSS sepsis ve VİK oranları artmaktadır Aradaki süre uzadıkça yenidoğan hastalık ve ölüm oranları artmaktadır Yatışta CRP son CRP doğum kilosu ve beşinci dakika APGAR skoru YYBB gereksinimyle; sadece beşinci dakika APGAR skoru SSS ile; son lökosit sayısı ve hematokrit ise sepsis ve pnömoniyle bağımsız olarak ilişkili bulunmuştur.

Çıkarımlar: Preterm erken mebran rüptürü olgularında sonuçları öngörebilmek için yatışta CRP son CRP doğum kilosu beşinci dakika APGAR skoru son lökosit sayısı ve annenin hemotokriti gözönünde bulundurulmalıdır.

Anahtar Kelimeler

• Neonatal morbidite
• neonatal
• mortalite

Kaynakça

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